Structure and function of histone acetyltransferase MOF
MOF was first identified in <i>Drosophila melanogaster</i> as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammali...
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| Format: | Article |
| Language: | English |
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AIMS Press
2015-10-01
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| Series: | AIMS Biophysics |
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| Online Access: | http://www.aimspress.com/biophysics/article/467/fulltext.html |
| _version_ | 1818508123768356864 |
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| author | Qiao Yi Chen Max Costa Hong Sun |
| author_facet | Qiao Yi Chen Max Costa Hong Sun |
| author_sort | Qiao Yi Chen |
| collection | DOAJ |
| description | MOF was first identified in <i>Drosophila melanogaster</i> as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays important roles in dosage compensation, ESC self-renewal, DNA damage and repair, cell survival, and gene expression regulation. Dysregulation of MOF has been implicated in tumor formation and progression of many types of human cancers. This review will discuss the structure and activity of mammalian hMOF as well as its function in H4K16 acetylation, DNA damage response, stem cell pluripotency, and carcinogenesis. |
| first_indexed | 2024-12-10T22:27:26Z |
| format | Article |
| id | doaj.art-b2038023c7d54a35a70c2f17c60d9737 |
| institution | Directory Open Access Journal |
| issn | 2377-9098 |
| language | English |
| last_indexed | 2024-12-10T22:27:26Z |
| publishDate | 2015-10-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Biophysics |
| spelling | doaj.art-b2038023c7d54a35a70c2f17c60d97372022-12-22T01:31:08ZengAIMS PressAIMS Biophysics2377-90982015-10-012455556910.3934/biophy.2015.4.555201504555Structure and function of histone acetyltransferase MOFQiao Yi Chen0Max Costa1Hong Sun2Department of Environmental Medicine, NYU School of Medicine, Tuxedo, NY 10987, USADepartment of Environmental Medicine, NYU School of Medicine, Tuxedo, NY 10987, USADepartment of Environmental Medicine, NYU School of Medicine, Tuxedo, NY 10987, USAMOF was first identified in <i>Drosophila melanogaster</i> as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays important roles in dosage compensation, ESC self-renewal, DNA damage and repair, cell survival, and gene expression regulation. Dysregulation of MOF has been implicated in tumor formation and progression of many types of human cancers. This review will discuss the structure and activity of mammalian hMOF as well as its function in H4K16 acetylation, DNA damage response, stem cell pluripotency, and carcinogenesis.http://www.aimspress.com/biophysics/article/467/fulltext.htmlMOFH4K16histone acetylationMSLNSL |
| spellingShingle | Qiao Yi Chen Max Costa Hong Sun Structure and function of histone acetyltransferase MOF AIMS Biophysics MOF H4K16 histone acetylation MSL NSL |
| title | Structure and function of histone acetyltransferase MOF |
| title_full | Structure and function of histone acetyltransferase MOF |
| title_fullStr | Structure and function of histone acetyltransferase MOF |
| title_full_unstemmed | Structure and function of histone acetyltransferase MOF |
| title_short | Structure and function of histone acetyltransferase MOF |
| title_sort | structure and function of histone acetyltransferase mof |
| topic | MOF H4K16 histone acetylation MSL NSL |
| url | http://www.aimspress.com/biophysics/article/467/fulltext.html |
| work_keys_str_mv | AT qiaoyichen structureandfunctionofhistoneacetyltransferasemof AT maxcosta structureandfunctionofhistoneacetyltransferasemof AT hongsun structureandfunctionofhistoneacetyltransferasemof |