ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome

ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome

Abstract Chronic inflammatory diseases are associated with hematopoietic lineage bias, including neutrophilia and anemia. We have recently identified that the canonical inflammasome mediates the cleavage of the master erythroid transcription factor GATA1 in hematopoietic stem and progenitor cells (H...

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Bibliographic Details
Main Authors: Lola Rodríguez‐Ruiz, Juan M Lozano‐Gil, Elena Naranjo‐Sánchez, Elena Martínez‐Balsalobre, Alicia Martínez‐López, Christophe Lachaud, Miguel Blanquer, Toan K Phung, Diana García‐Moreno, María L Cayuela, Sylwia D Tyrkalska, Ana B Pérez‐Oliva, Victoriano Mulero
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
anemia
HSPCs
inflammation
neutrophilia
zebrafish
Online Access:https://doi.org/10.15252/emmm.202318142

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