Protective Effect of Oral Extract of Stevia rebaudiana on Skin Flap Survival in Male Rats
Background and purpose: Due to the properties of Stevia, it seems that this plant can be effective in reducing oxidative damage consequent to ischemia-reperfusion, and increase the survival of skin flap. This research aimed at investigating the effects of oral extract of stevia on apoptosis and skin...
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Format: | Article |
Language: | English |
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Mazandaran University of Medical Sciences
2018-11-01
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Series: | Journal of Mazandaran University of Medical Sciences |
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Online Access: | http://jmums.mazums.ac.ir/article-1-11332-en.html |
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author | Majid Banimohammad Gholamali Javdan Shamim Samavat Ekbatan Mojtaba Safe Zohreh Hajheydari |
author_facet | Majid Banimohammad Gholamali Javdan Shamim Samavat Ekbatan Mojtaba Safe Zohreh Hajheydari |
author_sort | Majid Banimohammad |
collection | DOAJ |
description | Background and purpose: Due to the properties of Stevia, it seems that this plant can be effective in reducing oxidative damage consequent to ischemia-reperfusion, and increase the survival of skin flap. This research aimed at investigating the effects of oral extract of stevia on apoptosis and skin flap necrosis in rats.
Materials and methods: In this experimental study, Sprague Dawley rats were orally gavaged 25 mg/kg/daily of stevia leaf extract for one week, before or after the removal of flap. One week after surgery, the amount of flap necrosis, the content of malondialdehyde (MDA) in flap tissue, and superoxide dismutase (SOD) activity were measured.
Results: Pre-treatment or post-treatment with stevia leaf extract reduced the necrotic area in the flap compared to the control group. It also reduced the MDA content and increased SOD activity. Pre-treatment with stevia leaf extract was found to have a better protective effect than post-treatment in all variables investigated.
Conclusion: Current findings confirmed the survival of the flap with oral administration of stevia leaf extract. The beneficial effects of oral extract of stevia leaf can be clinically examined in reducing ischemic flap necrosis before and after surgery. |
first_indexed | 2024-04-10T20:29:54Z |
format | Article |
id | doaj.art-b207f3956a2946e29450c5945b124d81 |
institution | Directory Open Access Journal |
issn | 1735-9260 1735-9279 |
language | English |
last_indexed | 2024-04-10T20:29:54Z |
publishDate | 2018-11-01 |
publisher | Mazandaran University of Medical Sciences |
record_format | Article |
series | Journal of Mazandaran University of Medical Sciences |
spelling | doaj.art-b207f3956a2946e29450c5945b124d812023-01-25T07:27:00ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792018-11-012816619Protective Effect of Oral Extract of Stevia rebaudiana on Skin Flap Survival in Male RatsMajid Banimohammad0Gholamali Javdan1Shamim Samavat Ekbatan2Mojtaba Safe3Zohreh Hajheydari4 Medical Student, Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Assistant Professor, Minimally Invasive Surgery Research Center, Iran University of Medical Sciences Tehran, Iran MSc in Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran General Practitioner, Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Associate Professor, Department of Dermatology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Due to the properties of Stevia, it seems that this plant can be effective in reducing oxidative damage consequent to ischemia-reperfusion, and increase the survival of skin flap. This research aimed at investigating the effects of oral extract of stevia on apoptosis and skin flap necrosis in rats. Materials and methods: In this experimental study, Sprague Dawley rats were orally gavaged 25 mg/kg/daily of stevia leaf extract for one week, before or after the removal of flap. One week after surgery, the amount of flap necrosis, the content of malondialdehyde (MDA) in flap tissue, and superoxide dismutase (SOD) activity were measured. Results: Pre-treatment or post-treatment with stevia leaf extract reduced the necrotic area in the flap compared to the control group. It also reduced the MDA content and increased SOD activity. Pre-treatment with stevia leaf extract was found to have a better protective effect than post-treatment in all variables investigated. Conclusion: Current findings confirmed the survival of the flap with oral administration of stevia leaf extract. The beneficial effects of oral extract of stevia leaf can be clinically examined in reducing ischemic flap necrosis before and after surgery.http://jmums.mazums.ac.ir/article-1-11332-en.htmlstevia rebaudianamalondialdehydesuperoxide dismutaseskin flap |
spellingShingle | Majid Banimohammad Gholamali Javdan Shamim Samavat Ekbatan Mojtaba Safe Zohreh Hajheydari Protective Effect of Oral Extract of Stevia rebaudiana on Skin Flap Survival in Male Rats Journal of Mazandaran University of Medical Sciences stevia rebaudiana malondialdehyde superoxide dismutase skin flap |
title | Protective Effect of Oral Extract of Stevia rebaudiana on Skin Flap Survival in Male Rats |
title_full | Protective Effect of Oral Extract of Stevia rebaudiana on Skin Flap Survival in Male Rats |
title_fullStr | Protective Effect of Oral Extract of Stevia rebaudiana on Skin Flap Survival in Male Rats |
title_full_unstemmed | Protective Effect of Oral Extract of Stevia rebaudiana on Skin Flap Survival in Male Rats |
title_short | Protective Effect of Oral Extract of Stevia rebaudiana on Skin Flap Survival in Male Rats |
title_sort | protective effect of oral extract of stevia rebaudiana on skin flap survival in male rats |
topic | stevia rebaudiana malondialdehyde superoxide dismutase skin flap |
url | http://jmums.mazums.ac.ir/article-1-11332-en.html |
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