Off-Label Use of Bumetanide for Brain Disorders: An Overview

Off-Label Use of Bumetanide for Brain Disorders: An Overview

Bumetanide (BTN or BUM) is a FDA-approved potent loop diuretic (LD) that acts by antagonizing sodium-potassium-chloride (Na-K-Cl) cotransporters, NKCC1 (SLc12a2) and NKCC2. While NKCC1 is expressed both in the CNS and in systemic organs, NKCC2 is kidney-specific. The off-label use of BTN to modulate...

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Bibliographic Details
Main Authors: Shivani C. Kharod, Seok Kyu Kang, Shilpa D. Kadam
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neuroscience
Subjects:
bumetanide (BTN)
Na-K-Cl cotransporter 1 (NKCC1)
neonatal seizures
autism
schizophrenia
temporal lobe epilepsy (TLE)
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00310/full

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