GDF11 inhibits adipogenesis of human adipose-derived stromal cells through ALK5/KLF15/β-catenin/PPARγ cascade

GDF11 inhibits adipogenesis of human adipose-derived stromal cells through ALK5/KLF15/β-catenin/PPARγ cascade

Obesity is a metabolic disease characterized by excessive fat storage, and the adipogenic differentiation of adipose-derived stromal cells (ADSCs) is closely linked to its occurrence. Growth differentiation factor 11 (GDF11), a well-known molecule in the field of anti-aging, also has great potential...

Full description

Bibliographic Details
Main Authors: Shimin Lin, Lishan Zhong, Jingyi Chen, Zibo Zhao, Rongze Wang, Yexuan Zhu, Junwei Liu, Yanting Wu, Cuifang Ye, Fujun Jin, Zhe Ren
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Heliyon
Subjects:
GDF11
Adipogenesis
Obesity
KLF15
PPARγ
WNT/β-catenin pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023002955

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023002955

Similar Items