The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials
Aims: The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to examine the effect of cinnamon supplementation on liver enzymes. Methods: A systematic search was performed in electronic databases including PubMed-Medline, Scopus, and ISI Web...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-05-01
|
| Series: | Complementary Therapies in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229921000406 |
| _version_ | 1818597601538211840 |
|---|---|
| author | Parivash Shekarchizadeh-Esfahani Fatemeh Heydarpour Fatemeh Izadi Cyrus Jalili |
| author_facet | Parivash Shekarchizadeh-Esfahani Fatemeh Heydarpour Fatemeh Izadi Cyrus Jalili |
| author_sort | Parivash Shekarchizadeh-Esfahani |
| collection | DOAJ |
| description | Aims: The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to examine the effect of cinnamon supplementation on liver enzymes. Methods: A systematic search was performed in electronic databases including PubMed-Medline, Scopus, and ISI Web of Science up to November 2020. We used a random effects model to estimate pooled effect size of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and aspartate aminotransferase (AST) levels. Results: Seven RCTs (9 treatment arms) fulfilled the eligibility criteria of the present meta-analysis. Overall, meta-analysis could not show any beneficial effect of cinnamon supplementation on AST, ALT, and ALP. Subgroup analyses showed that the effect of cinnamon supplementation on ALT was significant at the dosages of <1500 mg/day (Hedges’s: -0.61; 95 % CI: -1.11, -0.10; P = 0.002), in trials lasting>12 weeks (Hedges’s: -0.83; 95 % CI: -1.36, -0.30; P = 0.01), and in trials conducted of both gender (Hedges’s: -0.72; 95 % CI: -1.45, -0.01; P = 0.04). Conclusion: In summary, cinnamon supplementation had no significant effect on liver enzymes in adults. However, the effect of cinnamon on ALT levels was significant at the dosages of <1500 mg/day, in trials lasting>12 weeks, and in trials conducted of both gender. Nevertheless, further studies should be performed to confirm our results. |
| first_indexed | 2024-12-16T11:50:24Z |
| format | Article |
| id | doaj.art-b20e6a0413cc4079b1789eaa06ecfffd |
| institution | Directory Open Access Journal |
| issn | 0965-2299 |
| language | English |
| last_indexed | 2024-12-16T11:50:24Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj.art-b20e6a0413cc4079b1789eaa06ecfffd2022-12-21T22:32:44ZengElsevierComplementary Therapies in Medicine0965-22992021-05-0158102699The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trialsParivash Shekarchizadeh-Esfahani0Fatemeh Heydarpour1Fatemeh Izadi2Cyrus Jalili3Department of General Courses, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, Isfahan, IranSocial Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranMedical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Corresponding author at: Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.Aims: The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to examine the effect of cinnamon supplementation on liver enzymes. Methods: A systematic search was performed in electronic databases including PubMed-Medline, Scopus, and ISI Web of Science up to November 2020. We used a random effects model to estimate pooled effect size of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and aspartate aminotransferase (AST) levels. Results: Seven RCTs (9 treatment arms) fulfilled the eligibility criteria of the present meta-analysis. Overall, meta-analysis could not show any beneficial effect of cinnamon supplementation on AST, ALT, and ALP. Subgroup analyses showed that the effect of cinnamon supplementation on ALT was significant at the dosages of <1500 mg/day (Hedges’s: -0.61; 95 % CI: -1.11, -0.10; P = 0.002), in trials lasting>12 weeks (Hedges’s: -0.83; 95 % CI: -1.36, -0.30; P = 0.01), and in trials conducted of both gender (Hedges’s: -0.72; 95 % CI: -1.45, -0.01; P = 0.04). Conclusion: In summary, cinnamon supplementation had no significant effect on liver enzymes in adults. However, the effect of cinnamon on ALT levels was significant at the dosages of <1500 mg/day, in trials lasting>12 weeks, and in trials conducted of both gender. Nevertheless, further studies should be performed to confirm our results.http://www.sciencedirect.com/science/article/pii/S0965229921000406CinnamonLiver enzymesSystematic reviewMeta-analysis |
| spellingShingle | Parivash Shekarchizadeh-Esfahani Fatemeh Heydarpour Fatemeh Izadi Cyrus Jalili The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials Complementary Therapies in Medicine Cinnamon Liver enzymes Systematic review Meta-analysis |
| title | The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials |
| title_full | The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials |
| title_short | The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials |
| title_sort | effect of cinnamon supplementation on liver enzymes in adults a systematic review and meta analysis of randomized controlled trials |
| topic | Cinnamon Liver enzymes Systematic review Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0965229921000406 |
| work_keys_str_mv | AT parivashshekarchizadehesfahani theeffectofcinnamonsupplementationonliverenzymesinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT fatemehheydarpour theeffectofcinnamonsupplementationonliverenzymesinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT fatemehizadi theeffectofcinnamonsupplementationonliverenzymesinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT cyrusjalili theeffectofcinnamonsupplementationonliverenzymesinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT parivashshekarchizadehesfahani effectofcinnamonsupplementationonliverenzymesinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT fatemehheydarpour effectofcinnamonsupplementationonliverenzymesinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT fatemehizadi effectofcinnamonsupplementationonliverenzymesinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT cyrusjalili effectofcinnamonsupplementationonliverenzymesinadultsasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |