Molecular Basis of the Function of Transcriptional Enhancers
Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/7/1620 |
| _version_ | 1797563247603220480 |
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| author | Airat N. Ibragimov Oleg V. Bylino Yulii V. Shidlovskii |
| author_facet | Airat N. Ibragimov Oleg V. Bylino Yulii V. Shidlovskii |
| author_sort | Airat N. Ibragimov |
| collection | DOAJ |
| description | Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription. |
| first_indexed | 2024-03-10T18:40:51Z |
| format | Article |
| id | doaj.art-b20e7ded84eb49899a4a346ae3fd6a05 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:40:51Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b20e7ded84eb49899a4a346ae3fd6a052023-11-20T05:54:17ZengMDPI AGCells2073-44092020-07-0197162010.3390/cells9071620Molecular Basis of the Function of Transcriptional EnhancersAirat N. Ibragimov0Oleg V. Bylino1Yulii V. Shidlovskii2Laboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, RussiaLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, RussiaLaboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, RussiaTranscriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription.https://www.mdpi.com/2073-4409/9/7/1620enhancerpromoterchromatintranscriptional burstingtranscription factoriesenhancer RNA |
| spellingShingle | Airat N. Ibragimov Oleg V. Bylino Yulii V. Shidlovskii Molecular Basis of the Function of Transcriptional Enhancers Cells enhancer promoter chromatin transcriptional bursting transcription factories enhancer RNA |
| title | Molecular Basis of the Function of Transcriptional Enhancers |
| title_full | Molecular Basis of the Function of Transcriptional Enhancers |
| title_fullStr | Molecular Basis of the Function of Transcriptional Enhancers |
| title_full_unstemmed | Molecular Basis of the Function of Transcriptional Enhancers |
| title_short | Molecular Basis of the Function of Transcriptional Enhancers |
| title_sort | molecular basis of the function of transcriptional enhancers |
| topic | enhancer promoter chromatin transcriptional bursting transcription factories enhancer RNA |
| url | https://www.mdpi.com/2073-4409/9/7/1620 |
| work_keys_str_mv | AT airatnibragimov molecularbasisofthefunctionoftranscriptionalenhancers AT olegvbylino molecularbasisofthefunctionoftranscriptionalenhancers AT yuliivshidlovskii molecularbasisofthefunctionoftranscriptionalenhancers |