Effects of statin therapy on chronic kidney disease patients with coronary artery disease
Abstract Background Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients. Until now, very few reports are available from China to address the effects of statin therapy in C...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-018-0742-4 |
| _version_ | 1811318206686560256 |
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| author | Hao Shen Xiaodong Chen Jingfen Lu Honglin Yang Yan Xu Ao Zhu Xiao Zhang Fulong Ye Yongchun Gu |
| author_facet | Hao Shen Xiaodong Chen Jingfen Lu Honglin Yang Yan Xu Ao Zhu Xiao Zhang Fulong Ye Yongchun Gu |
| author_sort | Hao Shen |
| collection | DOAJ |
| description | Abstract Background Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients. Until now, very few reports are available from China to address the effects of statin therapy in CKD + CAD patients. Methods We compared the effects of long-term statin therapy (follow-up time 4 years) in terms of cardiovascular events, all-cause death, and cardiac death among 254 CKD patients with or without CAD. Results Long-term statin therapy was much more effective in the CKD + CAD patients compared with CKD patients. In the CAD + CKD patients, long-term statins showed a 22.2% reduction in the CVs rate (P = 0.012). With regard to the all-cause and cardiac deaths, long-term statins had significant treatment effects on the CAD + CKD patients (reduction of about 28.1% in mortality rates, P < 0.001). In contrast, long-term statin therapy exerted no significant influence on the clinical outcomes of the CKD-only patients. Conclusion Long-term statin therapy more dramatically reduced the CVs and mortality rates of the CKD patients with concomitant CAD. In contrast, CKD-only patients had a good prognosis and did not appear to require statin treatment. |
| first_indexed | 2024-04-13T12:22:36Z |
| format | Article |
| id | doaj.art-b20f54fbdf8b491188497e21df077907 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-13T12:22:36Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-b20f54fbdf8b491188497e21df0779072022-12-22T02:47:10ZengBMCLipids in Health and Disease1476-511X2018-04-011711710.1186/s12944-018-0742-4Effects of statin therapy on chronic kidney disease patients with coronary artery diseaseHao Shen0Xiaodong Chen1Jingfen Lu2Honglin Yang3Yan Xu4Ao Zhu5Xiao Zhang6Fulong Ye7Yongchun Gu8Department of Clinical Laboratory Medicine, First People’s Hospital of Wujiang District, Nantong UniversityDepartment of Internal Medicine, First People’s Hospital of Wujiang District, Nantong UniversityDepartment of Clinical Laboratory Medicine, First People’s Hospital of Wujiang District, Nantong UniversityDepartment of Clinical Laboratory Medicine, First People’s Hospital of Wujiang District, Nantong UniversityDepartment of Nephrology, First People’s Hospital of Wujiang District, Nantong UniversityDepartment of Clinical Laboratory Medicine, First People’s Hospital of Wujiang District, Nantong UniversityDepartment of Clinical Laboratory Medicine, First People’s Hospital of Wujiang District, Nantong UniversityDepartment of Internal Medicine, First People’s Hospital of Wujiang District, Nantong UniversityDepartment of Central Laboratory, First People’s Hospital of Wujiang District, Nantong UniversityAbstract Background Long-term persistence of statin therapy provided an ongoing reduction in mortality among patients with and without a known history of CVD, and renoprotective effect on CKD patients. Until now, very few reports are available from China to address the effects of statin therapy in CKD + CAD patients. Methods We compared the effects of long-term statin therapy (follow-up time 4 years) in terms of cardiovascular events, all-cause death, and cardiac death among 254 CKD patients with or without CAD. Results Long-term statin therapy was much more effective in the CKD + CAD patients compared with CKD patients. In the CAD + CKD patients, long-term statins showed a 22.2% reduction in the CVs rate (P = 0.012). With regard to the all-cause and cardiac deaths, long-term statins had significant treatment effects on the CAD + CKD patients (reduction of about 28.1% in mortality rates, P < 0.001). In contrast, long-term statin therapy exerted no significant influence on the clinical outcomes of the CKD-only patients. Conclusion Long-term statin therapy more dramatically reduced the CVs and mortality rates of the CKD patients with concomitant CAD. In contrast, CKD-only patients had a good prognosis and did not appear to require statin treatment.http://link.springer.com/article/10.1186/s12944-018-0742-4Chronic kidney diseaseStatinCardiovascular events |
| spellingShingle | Hao Shen Xiaodong Chen Jingfen Lu Honglin Yang Yan Xu Ao Zhu Xiao Zhang Fulong Ye Yongchun Gu Effects of statin therapy on chronic kidney disease patients with coronary artery disease Lipids in Health and Disease Chronic kidney disease Statin Cardiovascular events |
| title | Effects of statin therapy on chronic kidney disease patients with coronary artery disease |
| title_full | Effects of statin therapy on chronic kidney disease patients with coronary artery disease |
| title_fullStr | Effects of statin therapy on chronic kidney disease patients with coronary artery disease |
| title_full_unstemmed | Effects of statin therapy on chronic kidney disease patients with coronary artery disease |
| title_short | Effects of statin therapy on chronic kidney disease patients with coronary artery disease |
| title_sort | effects of statin therapy on chronic kidney disease patients with coronary artery disease |
| topic | Chronic kidney disease Statin Cardiovascular events |
| url | http://link.springer.com/article/10.1186/s12944-018-0742-4 |
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