Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment
Type-1 cardiorenal syndrome refers to acute kidney injury induced by acute worsening cardiac function. Worsening renal function is a strong and independent predictive factor for poor prognosis. Currently, several problems of the type-1 cardiorenal syndrome have not been fully elucidated. The pathoge...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.760152/full |
| _version_ | 1819101410015313920 |
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| author | Kang Fu Yue Hu Hui Zhang Chen Wang Zongwei Lin Huixia Lu Xiaoping Ji |
| author_facet | Kang Fu Yue Hu Hui Zhang Chen Wang Zongwei Lin Huixia Lu Xiaoping Ji |
| author_sort | Kang Fu |
| collection | DOAJ |
| description | Type-1 cardiorenal syndrome refers to acute kidney injury induced by acute worsening cardiac function. Worsening renal function is a strong and independent predictive factor for poor prognosis. Currently, several problems of the type-1 cardiorenal syndrome have not been fully elucidated. The pathogenesis mechanism of renal dysfunction is unclear. Besides, the diagnostic efficiency, sensitivity, and specificity of the existing biomarkers are doubtful. Furthermore, the renal safety of the therapeutic strategies for acute heart failure (AHF) is still ambiguous. Based on these issues, we systematically summarized and depicted the research actualities and predicaments of the pathogenesis, diagnostic markers, and therapeutic strategies of worsening renal function in type-1 cardiorenal syndrome. |
| first_indexed | 2024-12-22T01:18:13Z |
| format | Article |
| id | doaj.art-b2101e8db3594f79b54d9e498e914246 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-22T01:18:13Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b2101e8db3594f79b54d9e498e9142462022-12-21T18:43:48ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-12-01810.3389/fcvm.2021.760152760152Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to TreatmentKang FuYue HuHui ZhangChen WangZongwei LinHuixia LuXiaoping JiType-1 cardiorenal syndrome refers to acute kidney injury induced by acute worsening cardiac function. Worsening renal function is a strong and independent predictive factor for poor prognosis. Currently, several problems of the type-1 cardiorenal syndrome have not been fully elucidated. The pathogenesis mechanism of renal dysfunction is unclear. Besides, the diagnostic efficiency, sensitivity, and specificity of the existing biomarkers are doubtful. Furthermore, the renal safety of the therapeutic strategies for acute heart failure (AHF) is still ambiguous. Based on these issues, we systematically summarized and depicted the research actualities and predicaments of the pathogenesis, diagnostic markers, and therapeutic strategies of worsening renal function in type-1 cardiorenal syndrome.https://www.frontiersin.org/articles/10.3389/fcvm.2021.760152/fullworsening renal functiontype 1 cardiorenal syndromeacute heart failurepathogenesisbiomarkertreatment |
| spellingShingle | Kang Fu Yue Hu Hui Zhang Chen Wang Zongwei Lin Huixia Lu Xiaoping Ji Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment Frontiers in Cardiovascular Medicine worsening renal function type 1 cardiorenal syndrome acute heart failure pathogenesis biomarker treatment |
| title | Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment |
| title_full | Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment |
| title_fullStr | Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment |
| title_full_unstemmed | Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment |
| title_short | Insights of Worsening Renal Function in Type 1 Cardiorenal Syndrome: From the Pathogenesis, Biomarkers to Treatment |
| title_sort | insights of worsening renal function in type 1 cardiorenal syndrome from the pathogenesis biomarkers to treatment |
| topic | worsening renal function type 1 cardiorenal syndrome acute heart failure pathogenesis biomarker treatment |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.760152/full |
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