Immunoregulatory Sertoli Cell Allografts Engineered to Express Human Insulin Survive Humoral-Mediated Rejection

Immunoregulatory Sertoli Cell Allografts Engineered to Express Human Insulin Survive Humoral-Mediated Rejection

An effective treatment and possible cure for type 1 diabetes is transplantation of pancreatic islets. Unfortunately, transplanted islets are rejected by the immune system with humoral-mediated responses being an important part of rejection. Sertoli cells (SC), an immune regulatory cell shown to surv...

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Bibliographic Details
Main Authors: Rachel L. Washburn, Taylor Hibler, Gurvinder Kaur, Anna Sabu-Kurian, Alissa Landefeld, Jannette M. Dufour
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
diabetes
insulin
Sertoli cells
complement
genetic engineering
transplantation
Online Access:https://www.mdpi.com/1422-0067/23/24/15894

Internet

https://www.mdpi.com/1422-0067/23/24/15894

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