Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization.
<h4>Introduction</h4>It is difficult to accurately predict the natural course of allergic rhinitis (AR), because it is affected by a wide variety of environmental influences, as well as genetic predisposition. Considering the high prevalence of allergic rhinitis in children and adolescen...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0210840 |
| _version_ | 1819033230094893056 |
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| author | Michelle J Suh Jin A Park Suk Won Chang Jeong Hong Kim Keun-Hwa Lee Seong-Chul Hong Hye-Sook Lee Ju Wan Kang |
| author_facet | Michelle J Suh Jin A Park Suk Won Chang Jeong Hong Kim Keun-Hwa Lee Seong-Chul Hong Hye-Sook Lee Ju Wan Kang |
| author_sort | Michelle J Suh |
| collection | DOAJ |
| description | <h4>Introduction</h4>It is difficult to accurately predict the natural course of allergic rhinitis (AR), because it is affected by a wide variety of environmental influences, as well as genetic predisposition. Considering the high prevalence of allergic rhinitis in children and adolescents, caregivers should be given appropriate information regarding the disease course. This study aimed to understand the prognosis of allergic rhinitis by examining the relationship between allergic sensitization and rhinitis symptoms during this developmental period.<h4>Methods</h4>This cross-sectional study included 1069 children aged 9-16 years from the Korean International Study of Asthma and Allergies in Childhood Survey database who had completed health questionnaires, and for whom skin prick test results were available. Data were collected during May 2016. The distribution of sensitization and allergic symptoms was compared by age groups (elementary, middle, and high school). Data were analyzed using linear-by-linear analysis.<h4>Results</h4>Sensitization to at least one tested allergen differed by age (59.2%, 58.3%, 68.2%, in elementary, middle, and high school students, respectively; p = 0.025), and seasonal allergen sensitization (35.0%, 37.1%, 53.9%, respectively) increased with age (p < 0.001). Conversely, the proportion of rhinitis symptoms among sensitized children decreased as age increased (58.80%, 52.90%, 49.70%, respectively; p = 0.047). However, the rate of non-allergic rhinitis was age-independent.<h4>Conclusion</h4>With increasing age during childhood and adolescence, symptomatic allergic rhinitis decreases; thus, subclinical allergic rhinitis increases. This suggests that the symptoms of later-sensitized children are less clearly manifested, or that the symptoms reduce as previously sensitized children mature. This should be clarified further in a longitudinal study. |
| first_indexed | 2024-12-21T07:14:32Z |
| format | Article |
| id | doaj.art-b2120ebf3cb548a9a11bcee001051114 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T07:14:32Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b2120ebf3cb548a9a11bcee0010511142022-12-21T19:11:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01141e021084010.1371/journal.pone.0210840Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization.Michelle J SuhJin A ParkSuk Won ChangJeong Hong KimKeun-Hwa LeeSeong-Chul HongHye-Sook LeeJu Wan Kang<h4>Introduction</h4>It is difficult to accurately predict the natural course of allergic rhinitis (AR), because it is affected by a wide variety of environmental influences, as well as genetic predisposition. Considering the high prevalence of allergic rhinitis in children and adolescents, caregivers should be given appropriate information regarding the disease course. This study aimed to understand the prognosis of allergic rhinitis by examining the relationship between allergic sensitization and rhinitis symptoms during this developmental period.<h4>Methods</h4>This cross-sectional study included 1069 children aged 9-16 years from the Korean International Study of Asthma and Allergies in Childhood Survey database who had completed health questionnaires, and for whom skin prick test results were available. Data were collected during May 2016. The distribution of sensitization and allergic symptoms was compared by age groups (elementary, middle, and high school). Data were analyzed using linear-by-linear analysis.<h4>Results</h4>Sensitization to at least one tested allergen differed by age (59.2%, 58.3%, 68.2%, in elementary, middle, and high school students, respectively; p = 0.025), and seasonal allergen sensitization (35.0%, 37.1%, 53.9%, respectively) increased with age (p < 0.001). Conversely, the proportion of rhinitis symptoms among sensitized children decreased as age increased (58.80%, 52.90%, 49.70%, respectively; p = 0.047). However, the rate of non-allergic rhinitis was age-independent.<h4>Conclusion</h4>With increasing age during childhood and adolescence, symptomatic allergic rhinitis decreases; thus, subclinical allergic rhinitis increases. This suggests that the symptoms of later-sensitized children are less clearly manifested, or that the symptoms reduce as previously sensitized children mature. This should be clarified further in a longitudinal study.https://doi.org/10.1371/journal.pone.0210840 |
| spellingShingle | Michelle J Suh Jin A Park Suk Won Chang Jeong Hong Kim Keun-Hwa Lee Seong-Chul Hong Hye-Sook Lee Ju Wan Kang Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization. PLoS ONE |
| title | Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization. |
| title_full | Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization. |
| title_fullStr | Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization. |
| title_full_unstemmed | Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization. |
| title_short | Chronological changes in rhinitis symptoms present in school-aged children with allergic sensitization. |
| title_sort | chronological changes in rhinitis symptoms present in school aged children with allergic sensitization |
| url | https://doi.org/10.1371/journal.pone.0210840 |
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