Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast Cancer
Background:Breast cancer (BC) is the most common malignancy in Iraqi women in the recent years. There are many indicated marker for detection BC and determination the development of the tumor stage, one of the most important marker is human epidermal growth factor receptor-2 (HER2). Objective:To...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-06-01
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| Series: | Diyala Journal of Medicine |
| Subjects: | |
| Online Access: | https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/251 |
| _version_ | 1797586330864058368 |
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| author | Hiba Hadi Rashid Walaa Najm Abood Nameer Fadhel Gaeb |
| author_facet | Hiba Hadi Rashid Walaa Najm Abood Nameer Fadhel Gaeb |
| author_sort | Hiba Hadi Rashid |
| collection | DOAJ |
| description |
Background:Breast cancer (BC) is the most common malignancy in Iraqi women in the recent years. There are many indicated marker for detection BC and determination the development of the tumor stage, one of the most important marker is human epidermal growth factor receptor-2 (HER2).
Objective:To evaluation of serum and tissue HER2 levels among BC women and non BC women.
Patients and Methods: Preoperative blood samples were collected from breast cancer women. Patients were newly diagnosing and did not receive neither radiotherapy nor chemotherapy treatment preoperatively.For the control, blood sample was collected from non-breast cancer women. All blood samples subjected to determine the serum HER-2 level.
Results: A total of 52 patients with breast cancer and 30 of control were included in this study. The result showed increasing significant in serum concentration of HER-2 among BC patient compared to control and tissue her-2 positive BC patient have significantly higher serum concentration of HER-2 compared to BC patients who were tissue her-2 negative (16.23±10.37 ng/ml, 10.33±5.73 ng/ml) respectively.
Conclusion: Serum HER-2 level was positively associated with tissue HER-2 level, for that is an important marker for diagnosis and monitoring BC progression.
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| first_indexed | 2024-03-11T00:21:48Z |
| format | Article |
| id | doaj.art-b2138f056ee94858a54c93872a9c43a9 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-11T00:21:48Z |
| publishDate | 2019-06-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-b2138f056ee94858a54c93872a9c43a92023-11-18T23:17:40ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-06-01162Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast CancerHiba Hadi RashidWalaa Najm AboodNameer Fadhel Gaeb Background:Breast cancer (BC) is the most common malignancy in Iraqi women in the recent years. There are many indicated marker for detection BC and determination the development of the tumor stage, one of the most important marker is human epidermal growth factor receptor-2 (HER2). Objective:To evaluation of serum and tissue HER2 levels among BC women and non BC women. Patients and Methods: Preoperative blood samples were collected from breast cancer women. Patients were newly diagnosing and did not receive neither radiotherapy nor chemotherapy treatment preoperatively.For the control, blood sample was collected from non-breast cancer women. All blood samples subjected to determine the serum HER-2 level. Results: A total of 52 patients with breast cancer and 30 of control were included in this study. The result showed increasing significant in serum concentration of HER-2 among BC patient compared to control and tissue her-2 positive BC patient have significantly higher serum concentration of HER-2 compared to BC patients who were tissue her-2 negative (16.23±10.37 ng/ml, 10.33±5.73 ng/ml) respectively. Conclusion: Serum HER-2 level was positively associated with tissue HER-2 level, for that is an important marker for diagnosis and monitoring BC progression. https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/251Breast cancer, serum HER2, tissue HER-2 |
| spellingShingle | Hiba Hadi Rashid Walaa Najm Abood Nameer Fadhel Gaeb Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast Cancer Diyala Journal of Medicine Breast cancer, serum HER2, tissue HER-2 |
| title | Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast Cancer |
| title_full | Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast Cancer |
| title_fullStr | Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast Cancer |
| title_full_unstemmed | Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast Cancer |
| title_short | Evaluation of Human Epidermal Growth Factor Receptor-2 in Iraqi Women with Breast Cancer |
| title_sort | evaluation of human epidermal growth factor receptor 2 in iraqi women with breast cancer |
| topic | Breast cancer, serum HER2, tissue HER-2 |
| url | https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/251 |
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