Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report
Abstract Background Parenchymal neurocysticercosis is a frequent cause of seizures in areas endemic for Taenia solium. At present there is scarce data on the evolution of the levels of circulating metacestodal antigen before, during and after treatment with anthelmintic drugs. Case presentation A pa...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12883-019-1282-x |
| _version_ | 1818161788430057472 |
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| author | Richar Rodríguez-Hidalgo Arturo Carpio Erwin Van den Enden Washington Benítez-Ortiz |
| author_facet | Richar Rodríguez-Hidalgo Arturo Carpio Erwin Van den Enden Washington Benítez-Ortiz |
| author_sort | Richar Rodríguez-Hidalgo |
| collection | DOAJ |
| description | Abstract Background Parenchymal neurocysticercosis is a frequent cause of seizures in areas endemic for Taenia solium. At present there is scarce data on the evolution of the levels of circulating metacestodal antigen before, during and after treatment with anthelmintic drugs. Case presentation A patient with paucisymptomatic neurocysticercosis (NCC) diagnosed by Ag-ELISA, and confirmed by MRI images, was treated with praziquantel, albendazole and dexamethasone. The level of circulating T. solium antigen was determined weekly. Circulating antigen disappeared from his blood within 14 days after the start of the treatment and correlated with the involution of the cysticerci in the brain shown by imaging. Seventeen years later, the patient has not shown any side effect nor symptoms related to the treatment or to NCC. Conclusions If this encouraging finding is confirmed in a larger series of patients, this technique could be used to determine parasitological cure after treatment and might complement or sometimes replace sequential MRI-imaging of the brain. |
| first_indexed | 2024-12-11T16:23:20Z |
| format | Article |
| id | doaj.art-b213c44c26694f3b8939410ef99eb4ac |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-11T16:23:20Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-b213c44c26694f3b8939410ef99eb4ac2022-12-22T00:58:47ZengBMCBMC Neurology1471-23772019-04-011911510.1186/s12883-019-1282-xMonitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case reportRichar Rodríguez-Hidalgo0Arturo Carpio1Erwin Van den Enden2Washington Benítez-Ortiz3Instituto de Investigación en Salud Pública y Zoonosis, Universidad Central del EcuadorFacultad de Ciencias Médicas, Universidad de CuencaDepartment of Clinical Sciences, Institute of Tropical MedicineInstituto de Investigación en Salud Pública y Zoonosis, Universidad Central del EcuadorAbstract Background Parenchymal neurocysticercosis is a frequent cause of seizures in areas endemic for Taenia solium. At present there is scarce data on the evolution of the levels of circulating metacestodal antigen before, during and after treatment with anthelmintic drugs. Case presentation A patient with paucisymptomatic neurocysticercosis (NCC) diagnosed by Ag-ELISA, and confirmed by MRI images, was treated with praziquantel, albendazole and dexamethasone. The level of circulating T. solium antigen was determined weekly. Circulating antigen disappeared from his blood within 14 days after the start of the treatment and correlated with the involution of the cysticerci in the brain shown by imaging. Seventeen years later, the patient has not shown any side effect nor symptoms related to the treatment or to NCC. Conclusions If this encouraging finding is confirmed in a larger series of patients, this technique could be used to determine parasitological cure after treatment and might complement or sometimes replace sequential MRI-imaging of the brain.http://link.springer.com/article/10.1186/s12883-019-1282-xNeurocysticercosisTaenia soliumTreatmentAlbendazolePraziquantel |
| spellingShingle | Richar Rodríguez-Hidalgo Arturo Carpio Erwin Van den Enden Washington Benítez-Ortiz Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report BMC Neurology Neurocysticercosis Taenia solium Treatment Albendazole Praziquantel |
| title | Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report |
| title_full | Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report |
| title_fullStr | Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report |
| title_full_unstemmed | Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report |
| title_short | Monitoring treatment of Taenia solium- neurocysticercosis by detection of circulating antigens: a case report |
| title_sort | monitoring treatment of taenia solium neurocysticercosis by detection of circulating antigens a case report |
| topic | Neurocysticercosis Taenia solium Treatment Albendazole Praziquantel |
| url | http://link.springer.com/article/10.1186/s12883-019-1282-x |
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