An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital
Objectives: To analyze clinical spectrum, seriousness, outcome, causality, severity and preventability of ADRs in geriatrics and pediatric patients. Materials and Methods: All ADRs reported in geriatrics (≥ 65 years) and pediatrics (≤ 12 years) indoor as well outdoor patients from January, 2010 to A...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Perspectives in Clinical Research |
| Subjects: | |
| Online Access: | http://www.picronline.org/article.asp?issn=2229-3485;year=2018;volume=9;issue=2;spage=70;epage=75;aulast=Amin |
| _version_ | 1828321331973718016 |
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| author | Saloni Amin Samidh Shah Mira Desai Asha Shah K M Maheriya |
| author_facet | Saloni Amin Samidh Shah Mira Desai Asha Shah K M Maheriya |
| author_sort | Saloni Amin |
| collection | DOAJ |
| description | Objectives: To analyze clinical spectrum, seriousness, outcome, causality, severity and preventability of ADRs in geriatrics and pediatric patients.
Materials and Methods: All ADRs reported in geriatrics (≥ 65 years) and pediatrics (≤ 12 years) indoor as well outdoor patients from January, 2010 to April, 2016 at ADR monitoring centre, Department of Pharmacology, B. J. Medical College and Civil Hospital were identified. A retrospective analysis was carried out for clinical presentation, causality (as per WHO-UMC scale and Naranjo's algorithm), severity (Hatwig and Seigel scale) and preventability (Schaumock and Thornton criteria).
Results: Out of 3690 ADRs, 160 were in geriatric patients (4.33%) while 231 in pediatric patients (6.26%). The most commonly affected body system was gastrointestinal (53, 33.13%) followed by neurological disorders (26, 16.25%) in geriatric patients. While in pediatric patients, the most commonly affected body system was skin and appendages (73, 31.60 %) followed by gastrointestinal disorders (58, 25.11%). The most common causal drugs in geriatric patients was cardiovascular (38, 23.75%) followed by antimicrobials (28, 13.25%). While in pediatric patients, the most common causal drug group was antimicrobials (85, 33.46%) followed by blood products (36, 14.12%). Total 17 ADRs reported following vaccination, 7 (41.17%) were injection site abscess and 11 (64.70%) were due to pentavalent vaccine. Polypharmacy was common in geriatrics (31, 19.37%). Causality assessment for majority of ADRs in geriatrics (83, 52.5%) and pediatrics (171, 67.32%) were probable.
Conclusion: ADRs are common in geriatric and pediatric patients usually within four weeks of oral therapy. Active surveillance of drug safety monitoring in these vulnerable population is recommended. |
| first_indexed | 2024-04-13T18:24:52Z |
| format | Article |
| id | doaj.art-b2141e834a1f47378bcdb4f9d4b1569a |
| institution | Directory Open Access Journal |
| issn | 2229-3485 |
| language | English |
| last_indexed | 2024-04-13T18:24:52Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Perspectives in Clinical Research |
| spelling | doaj.art-b2141e834a1f47378bcdb4f9d4b1569a2022-12-22T02:35:18ZengWolters Kluwer Medknow PublicationsPerspectives in Clinical Research2229-34852018-01-0192707510.4103/picr.PICR_64_17An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospitalSaloni AminSamidh ShahMira DesaiAsha ShahK M MaheriyaObjectives: To analyze clinical spectrum, seriousness, outcome, causality, severity and preventability of ADRs in geriatrics and pediatric patients. Materials and Methods: All ADRs reported in geriatrics (≥ 65 years) and pediatrics (≤ 12 years) indoor as well outdoor patients from January, 2010 to April, 2016 at ADR monitoring centre, Department of Pharmacology, B. J. Medical College and Civil Hospital were identified. A retrospective analysis was carried out for clinical presentation, causality (as per WHO-UMC scale and Naranjo's algorithm), severity (Hatwig and Seigel scale) and preventability (Schaumock and Thornton criteria). Results: Out of 3690 ADRs, 160 were in geriatric patients (4.33%) while 231 in pediatric patients (6.26%). The most commonly affected body system was gastrointestinal (53, 33.13%) followed by neurological disorders (26, 16.25%) in geriatric patients. While in pediatric patients, the most commonly affected body system was skin and appendages (73, 31.60 %) followed by gastrointestinal disorders (58, 25.11%). The most common causal drugs in geriatric patients was cardiovascular (38, 23.75%) followed by antimicrobials (28, 13.25%). While in pediatric patients, the most common causal drug group was antimicrobials (85, 33.46%) followed by blood products (36, 14.12%). Total 17 ADRs reported following vaccination, 7 (41.17%) were injection site abscess and 11 (64.70%) were due to pentavalent vaccine. Polypharmacy was common in geriatrics (31, 19.37%). Causality assessment for majority of ADRs in geriatrics (83, 52.5%) and pediatrics (171, 67.32%) were probable. Conclusion: ADRs are common in geriatric and pediatric patients usually within four weeks of oral therapy. Active surveillance of drug safety monitoring in these vulnerable population is recommended.http://www.picronline.org/article.asp?issn=2229-3485;year=2018;volume=9;issue=2;spage=70;epage=75;aulast=AminAdverse drug reactiongeriatricpediatricpharmacovigilance |
| spellingShingle | Saloni Amin Samidh Shah Mira Desai Asha Shah K M Maheriya An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital Perspectives in Clinical Research Adverse drug reaction geriatric pediatric pharmacovigilance |
| title | An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital |
| title_full | An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital |
| title_fullStr | An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital |
| title_full_unstemmed | An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital |
| title_short | An analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital |
| title_sort | analysis of adverse drug reactions in extremes of age group at tertiary care teaching hospital |
| topic | Adverse drug reaction geriatric pediatric pharmacovigilance |
| url | http://www.picronline.org/article.asp?issn=2229-3485;year=2018;volume=9;issue=2;spage=70;epage=75;aulast=Amin |
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