Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility.

Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility.

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids. Recent studies have established the 15-PGDH gene as a colon cancer suppressor.We evaluated 15-PDGH as a colon cancer...

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Bibliographic Details
Main Authors: Cheryl L Thompson, Stephen P Fink, James D Lutterbaugh, Robert C Elston, Martina L Veigl, Sanford D Markowitz, Li Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3661460?pdf=render

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