POSSIBILITIES OF PHARMACALOGIC THERAPY APPLIED IN ABNORMAL UTERINE BLEEDING
The range of alternatives to hysterectomy includes ‘expanded’ oral medical regimens, the levonorgestrel-releasing intrauterine system (LNG-IUS), a wide range of endometrial ablative techniques, and where fibroids are the primary pathology—myomectomy and uterine artery embolization. Since the researc...
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| Format: | Article |
| Language: | English |
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University in Nis, Faculty of Medicine
2006-07-01
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| Series: | Acta Medica Medianae |
| Subjects: | |
| Online Access: | http://publisher.medfak.ni.ac.rs/2006-html/3-broj/MOGUCNOSTI%20FARMAKOLOSKE%20TERAPIJE%20ABNORMALNIH.pdf |
| _version_ | 1818277773287882752 |
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| author | Valentina Nikolic Milan Stefanovic Srdjan Pesic |
| author_facet | Valentina Nikolic Milan Stefanovic Srdjan Pesic |
| author_sort | Valentina Nikolic |
| collection | DOAJ |
| description | The range of alternatives to hysterectomy includes ‘expanded’ oral medical regimens, the levonorgestrel-releasing intrauterine system (LNG-IUS), a wide range of endometrial ablative techniques, and where fibroids are the primary pathology—myomectomy and uterine artery embolization. Since the research has shown that hysterectomy is a highly effective treatment, these alternatives must be assessed against the recognized high satisfactory rates and improved quality of life reported following hysterectomy. Additional issues that would also need to be addressed include complication rates, side-effects, and cost-effectiveness. For women with prolonged abnormal uterine bleeding, recent research suggests that hysterectomy is significantly superior to an expanded medical treatment regimen for health-related quality-of-life measures. Satisfaction with the treatment, and health-related quality of life and psychosocial well-being, are reportedly similar between hysterectomy and the LNG-IUS, but the latter has the advantage of reduced cost. Endometrial ablation reduces menstrual blood flow, but its benefits relative to hysterectomy lessen over time. No large-scale studies have adequately compared uterine artery embolization or myomectomy to hysterectomy. Perhaps, the most telling finding from recent research with respect to the place of alternative therapies to hysterectomy is that the existence or advent of these alternatives has not reduced hysterectomy rates, but merely increased treatment options and interventions for excessive menstrual loss. |
| first_indexed | 2024-12-12T23:06:52Z |
| format | Article |
| id | doaj.art-b217b3178f8740c9995cb654aa103d40 |
| institution | Directory Open Access Journal |
| issn | 0365-4478 |
| language | English |
| last_indexed | 2024-12-12T23:06:52Z |
| publishDate | 2006-07-01 |
| publisher | University in Nis, Faculty of Medicine |
| record_format | Article |
| series | Acta Medica Medianae |
| spelling | doaj.art-b217b3178f8740c9995cb654aa103d402022-12-22T00:08:40ZengUniversity in Nis, Faculty of MedicineActa Medica Medianae0365-44782006-07-014534352POSSIBILITIES OF PHARMACALOGIC THERAPY APPLIED IN ABNORMAL UTERINE BLEEDINGValentina NikolicMilan StefanovicSrdjan PesicThe range of alternatives to hysterectomy includes ‘expanded’ oral medical regimens, the levonorgestrel-releasing intrauterine system (LNG-IUS), a wide range of endometrial ablative techniques, and where fibroids are the primary pathology—myomectomy and uterine artery embolization. Since the research has shown that hysterectomy is a highly effective treatment, these alternatives must be assessed against the recognized high satisfactory rates and improved quality of life reported following hysterectomy. Additional issues that would also need to be addressed include complication rates, side-effects, and cost-effectiveness. For women with prolonged abnormal uterine bleeding, recent research suggests that hysterectomy is significantly superior to an expanded medical treatment regimen for health-related quality-of-life measures. Satisfaction with the treatment, and health-related quality of life and psychosocial well-being, are reportedly similar between hysterectomy and the LNG-IUS, but the latter has the advantage of reduced cost. Endometrial ablation reduces menstrual blood flow, but its benefits relative to hysterectomy lessen over time. No large-scale studies have adequately compared uterine artery embolization or myomectomy to hysterectomy. Perhaps, the most telling finding from recent research with respect to the place of alternative therapies to hysterectomy is that the existence or advent of these alternatives has not reduced hysterectomy rates, but merely increased treatment options and interventions for excessive menstrual loss.http://publisher.medfak.ni.ac.rs/2006-html/3-broj/MOGUCNOSTI%20FARMAKOLOSKE%20TERAPIJE%20ABNORMALNIH.pdfabnormal uterine bleedingmenorrhagiahysterectomyquality of lifelevonorgestrel intrauterine system |
| spellingShingle | Valentina Nikolic Milan Stefanovic Srdjan Pesic POSSIBILITIES OF PHARMACALOGIC THERAPY APPLIED IN ABNORMAL UTERINE BLEEDING Acta Medica Medianae abnormal uterine bleeding menorrhagia hysterectomy quality of life levonorgestrel intrauterine system |
| title | POSSIBILITIES OF PHARMACALOGIC THERAPY APPLIED IN ABNORMAL UTERINE BLEEDING |
| title_full | POSSIBILITIES OF PHARMACALOGIC THERAPY APPLIED IN ABNORMAL UTERINE BLEEDING |
| title_fullStr | POSSIBILITIES OF PHARMACALOGIC THERAPY APPLIED IN ABNORMAL UTERINE BLEEDING |
| title_full_unstemmed | POSSIBILITIES OF PHARMACALOGIC THERAPY APPLIED IN ABNORMAL UTERINE BLEEDING |
| title_short | POSSIBILITIES OF PHARMACALOGIC THERAPY APPLIED IN ABNORMAL UTERINE BLEEDING |
| title_sort | possibilities of pharmacalogic therapy applied in abnormal uterine bleeding |
| topic | abnormal uterine bleeding menorrhagia hysterectomy quality of life levonorgestrel intrauterine system |
| url | http://publisher.medfak.ni.ac.rs/2006-html/3-broj/MOGUCNOSTI%20FARMAKOLOSKE%20TERAPIJE%20ABNORMALNIH.pdf |
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