Tensile Test of Human Lumbar Ligamentum Flavum: Age-Related Changes of Stiffness
The most common cause of lumbar spinal canal stenosis is age-related degenerative changes. The ligamentum flavum is said to become thicker and stiffer with age, based on several histological and cadaver studies. However, there are no studies determining the age-related changes of the mechanical prop...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/11/8/3337 |
| _version_ | 1797538493737467904 |
|---|---|
| author | Atsushi Mihara Norihiro Nishida Fei Jiang Junji Ohgi Yasuaki Imajo Hidenori Suzuki Masahiro Funaba Hiroki Yamagata Xian Chen Takashi Sakai |
| author_facet | Atsushi Mihara Norihiro Nishida Fei Jiang Junji Ohgi Yasuaki Imajo Hidenori Suzuki Masahiro Funaba Hiroki Yamagata Xian Chen Takashi Sakai |
| author_sort | Atsushi Mihara |
| collection | DOAJ |
| description | The most common cause of lumbar spinal canal stenosis is age-related degenerative changes. The ligamentum flavum is said to become thicker and stiffer with age, based on several histological and cadaver studies. However, there are no studies determining the age-related changes of the mechanical properties of the ligamentum flavum in live patients. We examined the mechanical properties of the ligamentum flavum of live patients and evaluated the age-related changes. A total of 44 patients undergoing decompression surgery due to lumbar disease at our institute were included. The ligamentum flavum was harvested from the decompression site as a part of a necessary procedure for decompression. The tensile test was performed for the harvested ligamentum flavum within 24 h of harvest. Age-related changes in the stiffness of the ligamentum flavum were evaluated. Age was the only factor that showed a significant correlation with stiffness on multiple regression analysis. We demonstrated that the mechanical properties of the ligamentum flavum change with age. |
| first_indexed | 2024-03-10T12:31:11Z |
| format | Article |
| id | doaj.art-b2188fb1239244cbb78600a34091e361 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T12:31:11Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-b2188fb1239244cbb78600a34091e3612023-11-21T14:39:09ZengMDPI AGApplied Sciences2076-34172021-04-01118333710.3390/app11083337Tensile Test of Human Lumbar Ligamentum Flavum: Age-Related Changes of StiffnessAtsushi Mihara0Norihiro Nishida1Fei Jiang2Junji Ohgi3Yasuaki Imajo4Hidenori Suzuki5Masahiro Funaba6Hiroki Yamagata7Xian Chen8Takashi Sakai9Department of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Mechanical Engineering, Yamaguchi University, 2-16-1 Tokiwadai Ube, Yamaguchi 755-8611, JapanDepartment of Mechanical Engineering, Yamaguchi University, 2-16-1 Tokiwadai Ube, Yamaguchi 755-8611, JapanDepartment of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanDepartment of Mechanical Engineering, Yamaguchi University, 2-16-1 Tokiwadai Ube, Yamaguchi 755-8611, JapanDepartment of Orthopedic Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, JapanThe most common cause of lumbar spinal canal stenosis is age-related degenerative changes. The ligamentum flavum is said to become thicker and stiffer with age, based on several histological and cadaver studies. However, there are no studies determining the age-related changes of the mechanical properties of the ligamentum flavum in live patients. We examined the mechanical properties of the ligamentum flavum of live patients and evaluated the age-related changes. A total of 44 patients undergoing decompression surgery due to lumbar disease at our institute were included. The ligamentum flavum was harvested from the decompression site as a part of a necessary procedure for decompression. The tensile test was performed for the harvested ligamentum flavum within 24 h of harvest. Age-related changes in the stiffness of the ligamentum flavum were evaluated. Age was the only factor that showed a significant correlation with stiffness on multiple regression analysis. We demonstrated that the mechanical properties of the ligamentum flavum change with age.https://www.mdpi.com/2076-3417/11/8/3337ligamentum flavumlumbar spinal canal stenosismechanical propertytensile teststiffness |
| spellingShingle | Atsushi Mihara Norihiro Nishida Fei Jiang Junji Ohgi Yasuaki Imajo Hidenori Suzuki Masahiro Funaba Hiroki Yamagata Xian Chen Takashi Sakai Tensile Test of Human Lumbar Ligamentum Flavum: Age-Related Changes of Stiffness Applied Sciences ligamentum flavum lumbar spinal canal stenosis mechanical property tensile test stiffness |
| title | Tensile Test of Human Lumbar Ligamentum Flavum: Age-Related Changes of Stiffness |
| title_full | Tensile Test of Human Lumbar Ligamentum Flavum: Age-Related Changes of Stiffness |
| title_fullStr | Tensile Test of Human Lumbar Ligamentum Flavum: Age-Related Changes of Stiffness |
| title_full_unstemmed | Tensile Test of Human Lumbar Ligamentum Flavum: Age-Related Changes of Stiffness |
| title_short | Tensile Test of Human Lumbar Ligamentum Flavum: Age-Related Changes of Stiffness |
| title_sort | tensile test of human lumbar ligamentum flavum age related changes of stiffness |
| topic | ligamentum flavum lumbar spinal canal stenosis mechanical property tensile test stiffness |
| url | https://www.mdpi.com/2076-3417/11/8/3337 |
| work_keys_str_mv | AT atsushimihara tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT norihironishida tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT feijiang tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT junjiohgi tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT yasuakiimajo tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT hidenorisuzuki tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT masahirofunaba tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT hirokiyamagata tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT xianchen tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness AT takashisakai tensiletestofhumanlumbarligamentumflavumagerelatedchangesofstiffness |