Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies
Current trends in the application of nanomaterials are emerging in the nano-biotechnological sector for development of medicines. Cyanobacteria (blue-green algae) are photosynthetic prokaryotes that have applications to human health and numerous biological activities as dietary supplements. Cyanobac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/6/179 |
| _version_ | 1828746363275313152 |
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| author | Vivek K. Bajpai Shruti Shukla Sung-Min Kang Seung Kyu Hwang Xinjie Song Yun Suk Huh Young-Kyu Han |
| author_facet | Vivek K. Bajpai Shruti Shukla Sung-Min Kang Seung Kyu Hwang Xinjie Song Yun Suk Huh Young-Kyu Han |
| author_sort | Vivek K. Bajpai |
| collection | DOAJ |
| description | Current trends in the application of nanomaterials are emerging in the nano-biotechnological sector for development of medicines. Cyanobacteria (blue-green algae) are photosynthetic prokaryotes that have applications to human health and numerous biological activities as dietary supplements. Cyanobacteria produce biologically active and chemically diverse compounds such as cyclic peptides, lipopeptides, fatty acid amides, alkaloids, and saccharides. More than 50% of marine cyanobacteria are potentially exploitable for the extraction of bioactive substances, which are effective in killing cancer cells by inducing apoptotic death. The current review emphasizes that not even 10% of microalgal bioactive components have reached commercialized platforms due to difficulties related to solubility. Considering these factors, they should be considered as a potential source of natural products for drug discovery and drug delivery approaches. Nanoformulations employing a wide variety of nanoparticles and their polymerized forms could be an emerging approach to the development of new cancer drugs. This review highlights recent research on microalgae-based medicines or compounds as well as their biomedical applications. This review further discusses the facts, limitations, and commercial market trends related to the use of microalgae for industrial and medicinal purposes. |
| first_indexed | 2024-04-14T04:23:12Z |
| format | Article |
| id | doaj.art-b219cfd9bebd4a3f8f6ae888d3e52571 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T04:23:12Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-b219cfd9bebd4a3f8f6ae888d3e525712022-12-22T02:12:26ZengMDPI AGMarine Drugs1660-33972018-05-0116617910.3390/md16060179md16060179Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer TherapiesVivek K. Bajpai0Shruti Shukla1Sung-Min Kang2Seung Kyu Hwang3Xinjie Song4Yun Suk Huh5Young-Kyu Han6Department of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul 04620, KoreaDepartment of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul 04620, KoreaWCSL of Integrated Human Airway-on-a-chip, Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Nam-gu, Incheon 22212, KoreaWCSL of Integrated Human Airway-on-a-chip, Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Nam-gu, Incheon 22212, KoreaDepartment of Food Science and Technology, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do 38541, KoreaWCSL of Integrated Human Airway-on-a-chip, Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, 100 Inha-ro, Nam-gu, Incheon 22212, KoreaDepartment of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul 04620, KoreaCurrent trends in the application of nanomaterials are emerging in the nano-biotechnological sector for development of medicines. Cyanobacteria (blue-green algae) are photosynthetic prokaryotes that have applications to human health and numerous biological activities as dietary supplements. Cyanobacteria produce biologically active and chemically diverse compounds such as cyclic peptides, lipopeptides, fatty acid amides, alkaloids, and saccharides. More than 50% of marine cyanobacteria are potentially exploitable for the extraction of bioactive substances, which are effective in killing cancer cells by inducing apoptotic death. The current review emphasizes that not even 10% of microalgal bioactive components have reached commercialized platforms due to difficulties related to solubility. Considering these factors, they should be considered as a potential source of natural products for drug discovery and drug delivery approaches. Nanoformulations employing a wide variety of nanoparticles and their polymerized forms could be an emerging approach to the development of new cancer drugs. This review highlights recent research on microalgae-based medicines or compounds as well as their biomedical applications. This review further discusses the facts, limitations, and commercial market trends related to the use of microalgae for industrial and medicinal purposes.http://www.mdpi.com/1660-3397/16/6/179microalgae/cyanobacteriananoformulationdrug developmentcommercial drawbacks |
| spellingShingle | Vivek K. Bajpai Shruti Shukla Sung-Min Kang Seung Kyu Hwang Xinjie Song Yun Suk Huh Young-Kyu Han Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies Marine Drugs microalgae/cyanobacteria nanoformulation drug development commercial drawbacks |
| title | Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies |
| title_full | Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies |
| title_fullStr | Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies |
| title_full_unstemmed | Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies |
| title_short | Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies |
| title_sort | developments of cyanobacteria for nano marine drugs relevance of nanoformulations in cancer therapies |
| topic | microalgae/cyanobacteria nanoformulation drug development commercial drawbacks |
| url | http://www.mdpi.com/1660-3397/16/6/179 |
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