Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment
Abstract Background Metabolic syndrome (MetS) exacerbates susceptibility to inhalation exposures such as particulate air pollution, however, the mechanisms responsible remain unelucidated. Previously, we determined a MetS mouse model exhibited exacerbated pulmonary inflammation 24 h following AgNP e...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Particle and Fibre Toxicology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12989-022-00495-6 |
| _version_ | 1811342855002652672 |
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| author | Saeed Alqahtani Li Xia Jonathan H. Shannahan |
| author_facet | Saeed Alqahtani Li Xia Jonathan H. Shannahan |
| author_sort | Saeed Alqahtani |
| collection | DOAJ |
| description | Abstract Background Metabolic syndrome (MetS) exacerbates susceptibility to inhalation exposures such as particulate air pollution, however, the mechanisms responsible remain unelucidated. Previously, we determined a MetS mouse model exhibited exacerbated pulmonary inflammation 24 h following AgNP exposure compared to a healthy mouse model. This enhanced response corresponded with reduction of distinct resolution mediators. We hypothesized silver nanoparticle (AgNP) exposure in MetS results in sustained pulmonary inflammation. Further, we hypothesized treatment with resolvin D1 (RvD1) will reduce exacerbations in AgNP-induced inflammation due to MetS. Results To evaluate these hypotheses, healthy and MetS mouse models were exposed to vehicle (control) or AgNPs and a day later, treated with resolvin D1 (RvD1) or vehicle (control) via oropharyngeal aspiration. Pulmonary lung toxicity was evaluated at 3-, 7-, 14-, and 21-days following AgNP exposure. MetS mice exposed to AgNPs and receiving vehicle treatment, demonstrated exacerbated pulmonary inflammatory responses compared to healthy mice. In the AgNP exposed mice receiving RvD1, pulmonary inflammatory response in MetS was reduced to levels comparable to healthy mice exposed to AgNPs. This included decreases in neutrophil influx and inflammatory cytokines, as well as elevated anti-inflammatory cytokines. Conclusions Inefficient resolution may contribute to enhancements in MetS susceptibility to AgNP exposure causing an increased pulmonary inflammatory response. Treatments utilizing specific resolution mediators may be beneficial to individuals suffering MetS following inhalation exposures. |
| first_indexed | 2024-04-13T19:18:16Z |
| format | Article |
| id | doaj.art-b21a03288e544e10ad62e3d67257767e |
| institution | Directory Open Access Journal |
| issn | 1743-8977 |
| language | English |
| last_indexed | 2024-04-13T19:18:16Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Particle and Fibre Toxicology |
| spelling | doaj.art-b21a03288e544e10ad62e3d67257767e2022-12-22T02:33:36ZengBMCParticle and Fibre Toxicology1743-89772022-08-0119111810.1186/s12989-022-00495-6Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatmentSaeed Alqahtani0Li Xia1Jonathan H. Shannahan2School of Health Sciences, College of Health and Human Sciences, Purdue UniversitySchool of Health Sciences, College of Health and Human Sciences, Purdue UniversitySchool of Health Sciences, College of Health and Human Sciences, Purdue UniversityAbstract Background Metabolic syndrome (MetS) exacerbates susceptibility to inhalation exposures such as particulate air pollution, however, the mechanisms responsible remain unelucidated. Previously, we determined a MetS mouse model exhibited exacerbated pulmonary inflammation 24 h following AgNP exposure compared to a healthy mouse model. This enhanced response corresponded with reduction of distinct resolution mediators. We hypothesized silver nanoparticle (AgNP) exposure in MetS results in sustained pulmonary inflammation. Further, we hypothesized treatment with resolvin D1 (RvD1) will reduce exacerbations in AgNP-induced inflammation due to MetS. Results To evaluate these hypotheses, healthy and MetS mouse models were exposed to vehicle (control) or AgNPs and a day later, treated with resolvin D1 (RvD1) or vehicle (control) via oropharyngeal aspiration. Pulmonary lung toxicity was evaluated at 3-, 7-, 14-, and 21-days following AgNP exposure. MetS mice exposed to AgNPs and receiving vehicle treatment, demonstrated exacerbated pulmonary inflammatory responses compared to healthy mice. In the AgNP exposed mice receiving RvD1, pulmonary inflammatory response in MetS was reduced to levels comparable to healthy mice exposed to AgNPs. This included decreases in neutrophil influx and inflammatory cytokines, as well as elevated anti-inflammatory cytokines. Conclusions Inefficient resolution may contribute to enhancements in MetS susceptibility to AgNP exposure causing an increased pulmonary inflammatory response. Treatments utilizing specific resolution mediators may be beneficial to individuals suffering MetS following inhalation exposures.https://doi.org/10.1186/s12989-022-00495-6Nanoparticles (NPs)Inflammatory resolutionSpecialized pro-resolving mediators (SPMs)Resolvin D1 (RvD1)Metabolic syndrome (MetS)Susceptibility |
| spellingShingle | Saeed Alqahtani Li Xia Jonathan H. Shannahan Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment Particle and Fibre Toxicology Nanoparticles (NPs) Inflammatory resolution Specialized pro-resolving mediators (SPMs) Resolvin D1 (RvD1) Metabolic syndrome (MetS) Susceptibility |
| title | Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment |
| title_full | Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment |
| title_fullStr | Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment |
| title_full_unstemmed | Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment |
| title_short | Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment |
| title_sort | enhanced silver nanoparticle induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin d1 treatment |
| topic | Nanoparticles (NPs) Inflammatory resolution Specialized pro-resolving mediators (SPMs) Resolvin D1 (RvD1) Metabolic syndrome (MetS) Susceptibility |
| url | https://doi.org/10.1186/s12989-022-00495-6 |
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