Solvent-Free Addition of Indole to Aldehydes: Unexpected Synthesis of Novel 1-[1-(1H-Indol-3-yl) Alkyl]-1H-Indoles and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells

Solvent-Free Addition of Indole to Aldehydes: Unexpected Synthesis of Novel 1-[1-(1H-Indol-3-yl) Alkyl]-1H-Indoles and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells

New 1-[1-(1H-indol-3-yl) alkyl]-1H-indoles, surprisingly, have been obtained from the addition of indole to a variety of aldehydes under neat conditions. CaO, present in excess, was fundamental for carrying out the reaction with paraformaldehyde. Under the same reaction conditions, aromatic and hete...

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Bibliographic Details
Main Authors:	Graziella Tocco, Gloria Zedda, Mariano Casu, Gabriella Simbula, Michela Begala
Format:	Article
Language:	English
Published:	MDPI AG 2017-10-01
Series:	Molecules
Subjects:	solvent-free reaction 1-[1-(1H-indol-3-yl) alkyl]-1H-indoles hepatocarcinoma cytotoxicity
Online Access:	https://www.mdpi.com/1420-3049/22/10/1747

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