<i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese Mice
This study investigated the potential fat-thermogenic effects of <i>Eurotium cristatum</i>, and elucidated the underlying mechanisms. The 12-week administration of <i>E. cristatum</i> in HFD-fed obese mice reduced body weight and improved glucolipid metabolism disorders. The...
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MDPI AG
2023-10-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/20/3716 |
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| author | Yu Wang Ting Li Chengcheng Yang Yingmei Wu Yueyue Liu Xingbin Yang |
| author_facet | Yu Wang Ting Li Chengcheng Yang Yingmei Wu Yueyue Liu Xingbin Yang |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | This study investigated the potential fat-thermogenic effects of <i>Eurotium cristatum</i>, and elucidated the underlying mechanisms. The 12-week administration of <i>E. cristatum</i> in HFD-fed obese mice reduced body weight and improved glucolipid metabolism disorders. The administration of <i>E. cristatum</i> also efficiently promoted thermogenesis by increasing the expression of UCP1 and PRDM16 in both interscapular brown adipose tissue (iBAT) and inguinal white adipose tissue (iWAT) of HFD-fed mice. Furthermore, <i>E. cristatum</i> shaped the gut microbiome by increasing the abundance of <i>Parabacteroides</i> and <i>Akkermansia muciniphila</i>, and also elevated the levels of cecal short-chain fatty acids, particularly propionate and acetate. Of note, <i>A. muciniphila</i> was highly negatively correlated with body weight gain (r = −0.801, <i>p</i> < 0.05) and the iWAT index (r = −0.977, <i>p</i> < 0.01), suggesting that <i>A. muciniphila</i> may play an important role in the thermogenic mobilization induced by <i>E. cristatum</i>. Continuous supplementation with <i>A. muciniphila</i> suppressed adipose accumulation, improved glucolipid metabolism, and enhanced the thermogenic activity of iWAT and iBAT. Collectively, our results propose that boosted <i>A. muciniphila</i> acts as a key microbe in tea-derived probiotic <i>E. cristatum</i>-mediated fat-thermogenic and anti-obesity effects. |
| first_indexed | 2024-03-10T21:15:56Z |
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| language | English |
| last_indexed | 2024-03-10T21:15:56Z |
| publishDate | 2023-10-01 |
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| record_format | Article |
| series | Foods |
| spelling | doaj.art-b21b157498a445acb3166d364813770a2023-11-19T16:28:43ZengMDPI AGFoods2304-81582023-10-011220371610.3390/foods12203716<i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese MiceYu Wang0Ting Li1Chengcheng Yang2Yingmei Wu3Yueyue Liu4Xingbin Yang5College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, ChinaCollege of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, ChinaCollege of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, ChinaCollege of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, ChinaCollege of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, ChinaCollege of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, ChinaThis study investigated the potential fat-thermogenic effects of <i>Eurotium cristatum</i>, and elucidated the underlying mechanisms. The 12-week administration of <i>E. cristatum</i> in HFD-fed obese mice reduced body weight and improved glucolipid metabolism disorders. The administration of <i>E. cristatum</i> also efficiently promoted thermogenesis by increasing the expression of UCP1 and PRDM16 in both interscapular brown adipose tissue (iBAT) and inguinal white adipose tissue (iWAT) of HFD-fed mice. Furthermore, <i>E. cristatum</i> shaped the gut microbiome by increasing the abundance of <i>Parabacteroides</i> and <i>Akkermansia muciniphila</i>, and also elevated the levels of cecal short-chain fatty acids, particularly propionate and acetate. Of note, <i>A. muciniphila</i> was highly negatively correlated with body weight gain (r = −0.801, <i>p</i> < 0.05) and the iWAT index (r = −0.977, <i>p</i> < 0.01), suggesting that <i>A. muciniphila</i> may play an important role in the thermogenic mobilization induced by <i>E. cristatum</i>. Continuous supplementation with <i>A. muciniphila</i> suppressed adipose accumulation, improved glucolipid metabolism, and enhanced the thermogenic activity of iWAT and iBAT. Collectively, our results propose that boosted <i>A. muciniphila</i> acts as a key microbe in tea-derived probiotic <i>E. cristatum</i>-mediated fat-thermogenic and anti-obesity effects.https://www.mdpi.com/2304-8158/12/20/3716Fu brick tea<i>Eurotium cristatum</i>fat thermogenesisgut microbiota<i>Akkermansia muciniphila</i> |
| spellingShingle | Yu Wang Ting Li Chengcheng Yang Yingmei Wu Yueyue Liu Xingbin Yang <i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese Mice Foods Fu brick tea <i>Eurotium cristatum</i> fat thermogenesis gut microbiota <i>Akkermansia muciniphila</i> |
| title | <i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese Mice |
| title_full | <i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese Mice |
| title_fullStr | <i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese Mice |
| title_full_unstemmed | <i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese Mice |
| title_short | <i>Eurotium cristatum</i> from Fu Brick Tea Promotes Adipose Thermogenesis by Boosting Colonic <i>Akkermansia muciniphila</i> in High-Fat-Fed Obese Mice |
| title_sort | i eurotium cristatum i from fu brick tea promotes adipose thermogenesis by boosting colonic i akkermansia muciniphila i in high fat fed obese mice |
| topic | Fu brick tea <i>Eurotium cristatum</i> fat thermogenesis gut microbiota <i>Akkermansia muciniphila</i> |
| url | https://www.mdpi.com/2304-8158/12/20/3716 |
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