Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new emerging respiratory virus, caused evolving pneumonia outbreak around the world. In SARS-Cov-2 infected patients, diabetes mellitus (DM) and obesity are two metabolic diseases associated with higher severity of SARS-CoV-2 related co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.676150/full |
| _version_ | 1819098586810417152 |
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| author | Marjan Nouri-Keshtkar Marjan Nouri-Keshtkar Sara Taghizadeh Sara Taghizadeh Aisan Farhadi Aisan Farhadi Aysan Ezaddoustdar Samira Vesali Roya Hosseini Mehdi Totonchi Mehdi Totonchi Azam Kouhkan Azam Kouhkan Chengshui Chen Jin-San Zhang Saverio Bellusci Saverio Bellusci Yaser Tahamtani Yaser Tahamtani Yaser Tahamtani |
| author_facet | Marjan Nouri-Keshtkar Marjan Nouri-Keshtkar Sara Taghizadeh Sara Taghizadeh Aisan Farhadi Aisan Farhadi Aysan Ezaddoustdar Samira Vesali Roya Hosseini Mehdi Totonchi Mehdi Totonchi Azam Kouhkan Azam Kouhkan Chengshui Chen Jin-San Zhang Saverio Bellusci Saverio Bellusci Yaser Tahamtani Yaser Tahamtani Yaser Tahamtani |
| author_sort | Marjan Nouri-Keshtkar |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new emerging respiratory virus, caused evolving pneumonia outbreak around the world. In SARS-Cov-2 infected patients, diabetes mellitus (DM) and obesity are two metabolic diseases associated with higher severity of SARS-CoV-2 related complications, characterized by acute lung injury requiring assisted ventilation as well as fibrosis development in surviving patients. Different factors are potentially responsible for this exacerbated response to SARS-CoV-2 infection. In patients with DM, base-line increase in inflammation and oxidative stress represent preexisting risk factors for virus-induced damages. Such factors are also likely to be found in obese patients. In addition, it has been proposed that massive injury to the alveolar epithelial type 2 (AT2) cells, which express the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2), leads to the activation of their stromal niches represented by the Lipofibroblasts (LIF). LIF are instrumental in maintaining the self-renewal of AT2 stem cells. LIF have been proposed to transdifferentiate into Myofibroblast (MYF) following injury to AT2 cells, thereby contributing to fibrosis. We hypothesized that LIF’s activity could be impacted by DM or obesity in an age- and gender-dependent manner, rendering them more prone to transition toward the profibrotic MYF status in the context of severe COVID-19 pneumonia. Understanding the cumulative effects of DM and/or obesity in the context of SARS-CoV-2 infection at the cellular level will be crucial for efficient therapeutic solutions. |
| first_indexed | 2024-12-22T00:33:21Z |
| format | Article |
| id | doaj.art-b21ce0918db846e38349f618b2d676f0 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T00:33:21Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b21ce0918db846e38349f618b2d676f02022-12-21T18:44:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.676150676150Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 InfectionMarjan Nouri-Keshtkar0Marjan Nouri-Keshtkar1Sara Taghizadeh2Sara Taghizadeh3Aisan Farhadi4Aisan Farhadi5Aysan Ezaddoustdar6Samira Vesali7Roya Hosseini8Mehdi Totonchi9Mehdi Totonchi10Azam Kouhkan11Azam Kouhkan12Chengshui Chen13Jin-San Zhang14Saverio Bellusci15Saverio Bellusci16Yaser Tahamtani17Yaser Tahamtani18Yaser Tahamtani19Faculty of Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, IranDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaExcellence Cluster Cardio-Pulmonary System, Justus Liebig University Giessen, Giessen, GermanyFaculty of Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, IranDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranFaculty of Veterinary Medicine, University of Tehran, Tehran, IranReproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranReproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranDepartment of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranReproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaExcellence Cluster Cardio-Pulmonary System, Justus Liebig University Giessen, Giessen, GermanyFaculty of Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, IranDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranReproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new emerging respiratory virus, caused evolving pneumonia outbreak around the world. In SARS-Cov-2 infected patients, diabetes mellitus (DM) and obesity are two metabolic diseases associated with higher severity of SARS-CoV-2 related complications, characterized by acute lung injury requiring assisted ventilation as well as fibrosis development in surviving patients. Different factors are potentially responsible for this exacerbated response to SARS-CoV-2 infection. In patients with DM, base-line increase in inflammation and oxidative stress represent preexisting risk factors for virus-induced damages. Such factors are also likely to be found in obese patients. In addition, it has been proposed that massive injury to the alveolar epithelial type 2 (AT2) cells, which express the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2), leads to the activation of their stromal niches represented by the Lipofibroblasts (LIF). LIF are instrumental in maintaining the self-renewal of AT2 stem cells. LIF have been proposed to transdifferentiate into Myofibroblast (MYF) following injury to AT2 cells, thereby contributing to fibrosis. We hypothesized that LIF’s activity could be impacted by DM or obesity in an age- and gender-dependent manner, rendering them more prone to transition toward the profibrotic MYF status in the context of severe COVID-19 pneumonia. Understanding the cumulative effects of DM and/or obesity in the context of SARS-CoV-2 infection at the cellular level will be crucial for efficient therapeutic solutions.https://www.frontiersin.org/articles/10.3389/fcell.2021.676150/fullSARS-CoV-2diabetes mellitusobesityinflammationLipofibroblastsangiotensin-converting enzyme 2 |
| spellingShingle | Marjan Nouri-Keshtkar Marjan Nouri-Keshtkar Sara Taghizadeh Sara Taghizadeh Aisan Farhadi Aisan Farhadi Aysan Ezaddoustdar Samira Vesali Roya Hosseini Mehdi Totonchi Mehdi Totonchi Azam Kouhkan Azam Kouhkan Chengshui Chen Jin-San Zhang Saverio Bellusci Saverio Bellusci Yaser Tahamtani Yaser Tahamtani Yaser Tahamtani Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection Frontiers in Cell and Developmental Biology SARS-CoV-2 diabetes mellitus obesity inflammation Lipofibroblasts angiotensin-converting enzyme 2 |
| title | Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection |
| title_full | Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection |
| title_fullStr | Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection |
| title_full_unstemmed | Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection |
| title_short | Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 Infection |
| title_sort | potential impact of diabetes and obesity on alveolar type 2 at2 lipofibroblast lif interactions after covid 19 infection |
| topic | SARS-CoV-2 diabetes mellitus obesity inflammation Lipofibroblasts angiotensin-converting enzyme 2 |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.676150/full |
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