Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure.
The exposures to extremely low frequency magnetic field (ELF-MF) in our environment have dramatically increased. Epidemiological studies suggest that there is a possible association between ELF-MF exposure and increased risks of cardiovascular disease, cancers and neurodegenerative disorders. Animal...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3343077?pdf=render |
| _version_ | 1819228999350484992 |
|---|---|
| author | Yonghua Cui Zhiqiang Ge Joshua Dominic Rizak Chao Zhai Zhu Zhou Songjie Gong Yi Che |
| author_facet | Yonghua Cui Zhiqiang Ge Joshua Dominic Rizak Chao Zhai Zhu Zhou Songjie Gong Yi Che |
| author_sort | Yonghua Cui |
| collection | DOAJ |
| description | The exposures to extremely low frequency magnetic field (ELF-MF) in our environment have dramatically increased. Epidemiological studies suggest that there is a possible association between ELF-MF exposure and increased risks of cardiovascular disease, cancers and neurodegenerative disorders. Animal studies show that ELF-MF exposure may interfere with the activity of brain cells, generate behavioral and cognitive disturbances, and produce deficits in attention, perception and spatial learning. Although, many research efforts have been focused on the interaction between ELF-MF exposure and the central nervous system, the mechanism of interaction is still unknown. In this study, we examined the effects of ELF-MF exposure on learning in mice using two water maze tasks and on some parameters indicative of oxidative stress in the hippocampus and striatum. We found that ELF-MF exposure (1 mT, 50 Hz) induced serious oxidative stress in the hippocampus and striatum and impaired hippocampal-dependent spatial learning and striatum-dependent habit learning. This study provides evidence for the association between the impairment of learning and the oxidative stress in hippocampus and striatum induced by ELF-MF exposure. |
| first_indexed | 2024-12-23T11:06:12Z |
| format | Article |
| id | doaj.art-b21d4859ab49416bb1af040ad0d36845 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T11:06:12Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b21d4859ab49416bb1af040ad0d368452022-12-21T17:49:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0175e3219610.1371/journal.pone.0032196Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure.Yonghua CuiZhiqiang GeJoshua Dominic RizakChao ZhaiZhu ZhouSongjie GongYi CheThe exposures to extremely low frequency magnetic field (ELF-MF) in our environment have dramatically increased. Epidemiological studies suggest that there is a possible association between ELF-MF exposure and increased risks of cardiovascular disease, cancers and neurodegenerative disorders. Animal studies show that ELF-MF exposure may interfere with the activity of brain cells, generate behavioral and cognitive disturbances, and produce deficits in attention, perception and spatial learning. Although, many research efforts have been focused on the interaction between ELF-MF exposure and the central nervous system, the mechanism of interaction is still unknown. In this study, we examined the effects of ELF-MF exposure on learning in mice using two water maze tasks and on some parameters indicative of oxidative stress in the hippocampus and striatum. We found that ELF-MF exposure (1 mT, 50 Hz) induced serious oxidative stress in the hippocampus and striatum and impaired hippocampal-dependent spatial learning and striatum-dependent habit learning. This study provides evidence for the association between the impairment of learning and the oxidative stress in hippocampus and striatum induced by ELF-MF exposure.http://europepmc.org/articles/PMC3343077?pdf=render |
| spellingShingle | Yonghua Cui Zhiqiang Ge Joshua Dominic Rizak Chao Zhai Zhu Zhou Songjie Gong Yi Che Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure. PLoS ONE |
| title | Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure. |
| title_full | Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure. |
| title_fullStr | Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure. |
| title_full_unstemmed | Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure. |
| title_short | Deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure. |
| title_sort | deficits in water maze performance and oxidative stress in the hippocampus and striatum induced by extremely low frequency magnetic field exposure |
| url | http://europepmc.org/articles/PMC3343077?pdf=render |
| work_keys_str_mv | AT yonghuacui deficitsinwatermazeperformanceandoxidativestressinthehippocampusandstriatuminducedbyextremelylowfrequencymagneticfieldexposure AT zhiqiangge deficitsinwatermazeperformanceandoxidativestressinthehippocampusandstriatuminducedbyextremelylowfrequencymagneticfieldexposure AT joshuadominicrizak deficitsinwatermazeperformanceandoxidativestressinthehippocampusandstriatuminducedbyextremelylowfrequencymagneticfieldexposure AT chaozhai deficitsinwatermazeperformanceandoxidativestressinthehippocampusandstriatuminducedbyextremelylowfrequencymagneticfieldexposure AT zhuzhou deficitsinwatermazeperformanceandoxidativestressinthehippocampusandstriatuminducedbyextremelylowfrequencymagneticfieldexposure AT songjiegong deficitsinwatermazeperformanceandoxidativestressinthehippocampusandstriatuminducedbyextremelylowfrequencymagneticfieldexposure AT yiche deficitsinwatermazeperformanceandoxidativestressinthehippocampusandstriatuminducedbyextremelylowfrequencymagneticfieldexposure |