Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications
Implantable biomedical devices require an anti-biofouling, mechanically robust, low friction surface for a prolonged lifespan and improved performance. However, there exist no methods that could provide uniform and effective coatings for medical devices with complex shapes and materials to prevent i...
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-07-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22003176 |
| _version_ | 1827267166288740352 |
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| author | Kijun Park Seunghoi Kim Yejin Jo Jae Park Inwoo Kim Sooyoung Hwang Yeontaek Lee So Yeon Kim Jungmok Seo |
| author_facet | Kijun Park Seunghoi Kim Yejin Jo Jae Park Inwoo Kim Sooyoung Hwang Yeontaek Lee So Yeon Kim Jungmok Seo |
| author_sort | Kijun Park |
| collection | DOAJ |
| description | Implantable biomedical devices require an anti-biofouling, mechanically robust, low friction surface for a prolonged lifespan and improved performance. However, there exist no methods that could provide uniform and effective coatings for medical devices with complex shapes and materials to prevent immune-related side effects and thrombosis when they encounter biological tissues. Here, we report a lubricant skin (L-skin), a coating method based on the application of thin layers of bio-adhesive and lubricant-swellable perfluoropolymer that impart anti-biofouling, frictionless, robust, and heat-mediated self-healing properties. We demonstrate biocompatible, mechanically robust, and sterilization-safe L-skin in applications of bioprinting, microfluidics, catheter, and long and narrow medical tubing. We envision that diverse applications of L-skin improve device longevity, as well as anti-biofouling attributes in biomedical devices with complex shapes and material compositions. |
| first_indexed | 2024-04-09T21:56:41Z |
| format | Article |
| id | doaj.art-b21de9afbafd481899f994bc817d1290 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2025-03-22T04:29:25Z |
| publishDate | 2023-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-b21de9afbafd481899f994bc817d12902024-04-28T04:35:02ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-07-0125555568Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applicationsKijun Park0Seunghoi Kim1Yejin Jo2Jae Park3Inwoo Kim4Sooyoung Hwang5Yeontaek Lee6So Yeon Kim7Jungmok Seo8School of Electronic and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of KoreaCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technologies, Seoul, 02792, Republic of KoreaSchool of Electronic and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of KoreaSchool of Electronic and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technologies, Seoul, 02792, Republic of KoreaSchool of Electronic and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of KoreaSchool of Electronic and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of KoreaCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technologies, Seoul, 02792, Republic of KoreaSchool of Electronic and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea; Corresponding author.Implantable biomedical devices require an anti-biofouling, mechanically robust, low friction surface for a prolonged lifespan and improved performance. However, there exist no methods that could provide uniform and effective coatings for medical devices with complex shapes and materials to prevent immune-related side effects and thrombosis when they encounter biological tissues. Here, we report a lubricant skin (L-skin), a coating method based on the application of thin layers of bio-adhesive and lubricant-swellable perfluoropolymer that impart anti-biofouling, frictionless, robust, and heat-mediated self-healing properties. We demonstrate biocompatible, mechanically robust, and sterilization-safe L-skin in applications of bioprinting, microfluidics, catheter, and long and narrow medical tubing. We envision that diverse applications of L-skin improve device longevity, as well as anti-biofouling attributes in biomedical devices with complex shapes and material compositions.http://www.sciencedirect.com/science/article/pii/S2452199X22003176Anti-biofoulingLubricant-infusedBiomedical applicationsBiomaterialsBiointerface |
| spellingShingle | Kijun Park Seunghoi Kim Yejin Jo Jae Park Inwoo Kim Sooyoung Hwang Yeontaek Lee So Yeon Kim Jungmok Seo Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications Bioactive Materials Anti-biofouling Lubricant-infused Biomedical applications Biomaterials Biointerface |
| title | Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications |
| title_full | Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications |
| title_fullStr | Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications |
| title_full_unstemmed | Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications |
| title_short | Lubricant skin on diverse biomaterials with complex shapes via polydopamine-mediated surface functionalization for biomedical applications |
| title_sort | lubricant skin on diverse biomaterials with complex shapes via polydopamine mediated surface functionalization for biomedical applications |
| topic | Anti-biofouling Lubricant-infused Biomedical applications Biomaterials Biointerface |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22003176 |
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