Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patient...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256&lng=en&tlng=en |
| _version_ | 1817988801620869120 |
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| author | Silmara Cristiane da Silveira Andreoli Nina Jardim Gasparini Gisele Pereira de Carvalho Bernardo Garicochea Robert Edward Pogue Rosângela Vieira de Andrade |
| author_facet | Silmara Cristiane da Silveira Andreoli Nina Jardim Gasparini Gisele Pereira de Carvalho Bernardo Garicochea Robert Edward Pogue Rosângela Vieira de Andrade |
| author_sort | Silmara Cristiane da Silveira Andreoli |
| collection | DOAJ |
| description | Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer. |
| first_indexed | 2024-04-14T00:38:59Z |
| format | Article |
| id | doaj.art-b21e63ff896145e7ba1557a4a8370687 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-04-14T00:38:59Z |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-b21e63ff896145e7ba1557a4a83706872022-12-22T02:22:16ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-638512225625810.1590/S1679-45082014MD2839S1679-45082014000200256Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancerSilmara Cristiane da Silveira AndreoliNina Jardim GaspariniGisele Pereira de CarvalhoBernardo GaricocheaRobert Edward PogueRosângela Vieira de AndradeColorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256&lng=en&tlng=enMicroRNAsMarcadores biológicosNeoplasias colorretais/quimioterapiaResultado de tratamentoTerapia combinada |
| spellingShingle | Silmara Cristiane da Silveira Andreoli Nina Jardim Gasparini Gisele Pereira de Carvalho Bernardo Garicochea Robert Edward Pogue Rosângela Vieira de Andrade Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer Einstein (São Paulo) MicroRNAs Marcadores biológicos Neoplasias colorretais/quimioterapia Resultado de tratamento Terapia combinada |
| title | Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer |
| title_full | Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer |
| title_fullStr | Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer |
| title_full_unstemmed | Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer |
| title_short | Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer |
| title_sort | use of micrornas in directing therapy and evaluating treatment response in colorectal cancer |
| topic | MicroRNAs Marcadores biológicos Neoplasias colorretais/quimioterapia Resultado de tratamento Terapia combinada |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082014000200256&lng=en&tlng=en |
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