Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice
Background: Grape seed is a natural herb with many suggested pharmacological effects related to many biologically active compounds in its extract and fractions. Grape seed pharmacological effect is investigated in mice psoriasis like model. Methods: A thirty male albino mice, six weeks’ age used...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2024-04-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1062 |
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| author | Mohammed Fareed Ayah F. Al-Qrimli |
| author_facet | Mohammed Fareed Ayah F. Al-Qrimli |
| author_sort | Mohammed Fareed |
| collection | DOAJ |
| description |
Background: Grape seed is a natural herb with many suggested pharmacological effects related to many biologically active compounds in its extract and fractions. Grape seed pharmacological effect is investigated in mice psoriasis like model.
Methods: A thirty male albino mice, six weeks’ age used in this research and were divided into five groups. Group I apparently healthy. Group II induction group, imiquimod 5% cream once daily used at the back skin of the animal for five days. Group III, IV and V treatments groups. Group III clobetasol ointment 0.05%, group IV Grape seed extract and group V Grape seed petroleum ether fraction for five days. Results: A high significant increase was found between the apparently healthy and imiquimod induced group for all of the investigated parameters except munro abscess was significant increase. For the grape seed extract group, it was found A significant difference in immunohistochemistry score of IL17, also significant decrease in vascular endothelial growth factor (VEGF) with high significant decrease of other immunohistopathology measurement like parakeratosis. Conclusion: Grape seed extract may have a role in imiquimod-induced psoriasis like skin inflammation in mice treatment which make it a future candidate therapy for psoriasis.
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| first_indexed | 2024-04-24T12:29:55Z |
| format | Article |
| id | doaj.art-b21f1262ae95485699e8f8198f2c5512 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T12:29:55Z |
| publishDate | 2024-04-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-b21f1262ae95485699e8f8198f2c55122024-04-08T06:58:17ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2024-04-0124210.32947/ajps.v24i2.1062Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in MiceMohammed Fareed0Ayah F. Al-Qrimli1University of AL-Nahrain / College of PharmacyUniversity of AL-Nahrain / College of Pharmacy Background: Grape seed is a natural herb with many suggested pharmacological effects related to many biologically active compounds in its extract and fractions. Grape seed pharmacological effect is investigated in mice psoriasis like model. Methods: A thirty male albino mice, six weeks’ age used in this research and were divided into five groups. Group I apparently healthy. Group II induction group, imiquimod 5% cream once daily used at the back skin of the animal for five days. Group III, IV and V treatments groups. Group III clobetasol ointment 0.05%, group IV Grape seed extract and group V Grape seed petroleum ether fraction for five days. Results: A high significant increase was found between the apparently healthy and imiquimod induced group for all of the investigated parameters except munro abscess was significant increase. For the grape seed extract group, it was found A significant difference in immunohistochemistry score of IL17, also significant decrease in vascular endothelial growth factor (VEGF) with high significant decrease of other immunohistopathology measurement like parakeratosis. Conclusion: Grape seed extract may have a role in imiquimod-induced psoriasis like skin inflammation in mice treatment which make it a future candidate therapy for psoriasis. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1062psoriasisvitis viniferagrapeImiquimod |
| spellingShingle | Mohammed Fareed Ayah F. Al-Qrimli Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice Al-Mustansiriyah Journal of Pharmaceutical Sciences psoriasis vitis vinifera grape Imiquimod |
| title | Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice |
| title_full | Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice |
| title_fullStr | Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice |
| title_full_unstemmed | Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice |
| title_short | Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice |
| title_sort | effects of topical petroleum ether and ethyl acetate fractions from grape seed extract on imiquimod induced psoriasis like skin inflammation in mice |
| topic | psoriasis vitis vinifera grape Imiquimod |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1062 |
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