Libman-Sacks endocarditis in a child with systemic lupus erythematosus: a case report and literature review
Libman-Sacks endocarditis (LSE) is a cardiac condition characterized by the growth of verrucous vegetation. Although relatively rare in children, LSE is nevertheless a known cardiac manifestation of autoimmune diseases, including systemic lupus erythematosus (SLE). The mitral valve is the most commo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1323943/full |
| _version_ | 1797338440907358208 |
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| author | Jingyi Lu Shengfang Bao Xuemei Xu Yingying Jin Chenxi Liu Yuqi Zhang Qian Wang Yanliang Jin |
| author_facet | Jingyi Lu Shengfang Bao Xuemei Xu Yingying Jin Chenxi Liu Yuqi Zhang Qian Wang Yanliang Jin |
| author_sort | Jingyi Lu |
| collection | DOAJ |
| description | Libman-Sacks endocarditis (LSE) is a cardiac condition characterized by the growth of verrucous vegetation. Although relatively rare in children, LSE is nevertheless a known cardiac manifestation of autoimmune diseases, including systemic lupus erythematosus (SLE). The mitral valve is the most commonly affected region, followed by the aortic valve, while the tricuspid and pulmonary valves are rarely affected. The management of established Libman-Sacks vegetation poses significant challenges, often necessitating surgical interventions, although surgery is not the primary treatment modality. Herein, we present the case of a 14-year-old Chinese female patient whose initial lupus manifestation included LSE, among other symptoms and signs that provided insights into the final diagnosis of SLE. After early comprehensive pharmacological treatment, tricuspid regurgitation and vegetation disappeared within 28 days without necessitating cardiac surgery, indicating that the resolution of LSE vegetation in this patient was achieved through a combination of immunosuppressive and anticoagulant therapy. These findings suggest the potential of this treatment approach as a viable model for the management of LSE in young patients. |
| first_indexed | 2024-03-08T09:30:15Z |
| format | Article |
| id | doaj.art-b2217a4f01494735a654a084c18c9791 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T09:30:15Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-b2217a4f01494735a654a084c18c97912024-01-31T04:36:06ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-01-011210.3389/fped.2024.13239431323943Libman-Sacks endocarditis in a child with systemic lupus erythematosus: a case report and literature reviewJingyi Lu0Shengfang Bao1Xuemei Xu2Yingying Jin3Chenxi Liu4Yuqi Zhang5Qian Wang6Yanliang Jin7Department of Rheumatology and Immunology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Rheumatology and Immunology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Rheumatology and Immunology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Rheumatology and Immunology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Rheumatology and Immunology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Pediatric Cardiology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDiagnostic Imaging Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Rheumatology and Immunology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaLibman-Sacks endocarditis (LSE) is a cardiac condition characterized by the growth of verrucous vegetation. Although relatively rare in children, LSE is nevertheless a known cardiac manifestation of autoimmune diseases, including systemic lupus erythematosus (SLE). The mitral valve is the most commonly affected region, followed by the aortic valve, while the tricuspid and pulmonary valves are rarely affected. The management of established Libman-Sacks vegetation poses significant challenges, often necessitating surgical interventions, although surgery is not the primary treatment modality. Herein, we present the case of a 14-year-old Chinese female patient whose initial lupus manifestation included LSE, among other symptoms and signs that provided insights into the final diagnosis of SLE. After early comprehensive pharmacological treatment, tricuspid regurgitation and vegetation disappeared within 28 days without necessitating cardiac surgery, indicating that the resolution of LSE vegetation in this patient was achieved through a combination of immunosuppressive and anticoagulant therapy. These findings suggest the potential of this treatment approach as a viable model for the management of LSE in young patients.https://www.frontiersin.org/articles/10.3389/fped.2024.1323943/fullLibman-Sacks endocarditissystemic lupus erythematosusimmunosuppressive therapychildrencase report |
| spellingShingle | Jingyi Lu Shengfang Bao Xuemei Xu Yingying Jin Chenxi Liu Yuqi Zhang Qian Wang Yanliang Jin Libman-Sacks endocarditis in a child with systemic lupus erythematosus: a case report and literature review Frontiers in Pediatrics Libman-Sacks endocarditis systemic lupus erythematosus immunosuppressive therapy children case report |
| title | Libman-Sacks endocarditis in a child with systemic lupus erythematosus: a case report and literature review |
| title_full | Libman-Sacks endocarditis in a child with systemic lupus erythematosus: a case report and literature review |
| title_fullStr | Libman-Sacks endocarditis in a child with systemic lupus erythematosus: a case report and literature review |
| title_full_unstemmed | Libman-Sacks endocarditis in a child with systemic lupus erythematosus: a case report and literature review |
| title_short | Libman-Sacks endocarditis in a child with systemic lupus erythematosus: a case report and literature review |
| title_sort | libman sacks endocarditis in a child with systemic lupus erythematosus a case report and literature review |
| topic | Libman-Sacks endocarditis systemic lupus erythematosus immunosuppressive therapy children case report |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1323943/full |
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