A city park as a potential epidemic site of scrub typhus: a case–control study of an outbreak in Guangzhou, China
Abstract Background Scrub typhus is an important public health problem in China, especially in Guangzhou city. Typical outbreaks of scrub typhus have been previously reported in rural areas, affecting mainly farmers. We describe an atypical outbreak of the disease with case fatalities, from a park i...
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| Format: | Article |
| Language: | English |
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BMC
2014-11-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13071-014-0513-7 |
| _version_ | 1827933648919199744 |
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| author | Yuehong Wei Lei Luo Qinlong Jing Xiaoning Li Yong Huang Xincai Xiao Lan Liu Xinwei Wu Zhicong Yang |
| author_facet | Yuehong Wei Lei Luo Qinlong Jing Xiaoning Li Yong Huang Xincai Xiao Lan Liu Xinwei Wu Zhicong Yang |
| author_sort | Yuehong Wei |
| collection | DOAJ |
| description | Abstract Background Scrub typhus is an important public health problem in China, especially in Guangzhou city. Typical outbreaks of scrub typhus have been previously reported in rural areas, affecting mainly farmers. We describe an atypical outbreak of the disease with case fatalities, from a park in Haizhu District, Guangzhou, that could turn out to be a potential scrub typhus epidemic site. Methods From May 2012 to June 2012, a case–control study was conducted to identify source and risk factors of this outbreak. Reported cases of scrub typhus in Xiaogang Park were confirmed by Weil–Felix test or a nested polymerase chain reaction (NPCR). Controls were matched with their neighbors by gender and age. Multivariate conditional logistic regression was used to identify risk factors and protective factors. Results A total of 29 cases were confirmed by Weil–Felix test, including 4 deaths by both Weil–Felix test and NPCR. All patients presented with fever (100%), while 28 (96.6%) cases had eschars, 10 (34.5%) headache, 10 (34.5%) chills, 6 (20.7%) lymphadenopathy, 5 (17.2%) rash, 2 (6.9%) vomiting and 1 (3.5%) presented with conjunctival congestion. The proportion of cases with activity history in Xiaogang Park was much higher than the control group (72.4% vs 24.1%, P < 0.001), and morning exercise in park or field was also as a risk factor for scrub typhus (adjusted OR = 3.0, 95% CI: 1.1 - 8.2). Four factors were significantly associated with the risk of developing scrub typhus: sitting on the lawn (adjusted OR = 8.0, 95% CI: 1.4 - 44.5), close contact with rats (adjusted OR = 3.3, 95% CI: 1.2 -9.6), sitting near the rat holes (OR = 6.8, 95% CI: 1.2 - 38.1) and wearing long-sleeved clothing when outside (adjusted OR = 0.3, 95% CI: 0.1 - 0.7). Conclusions We confirmed an atypical outbreak of scrub typhus in a park in Guangzhou city, which has the potential to develop into an important epidemic site. This public health risk should not be neglected and requires more attention from authorities. |
| first_indexed | 2024-03-13T07:27:41Z |
| format | Article |
| id | doaj.art-b221b02d221d49a0b12c4e5d3ad43a29 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-03-13T07:27:41Z |
| publishDate | 2014-11-01 |
| publisher | BMC |
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| series | Parasites & Vectors |
| spelling | doaj.art-b221b02d221d49a0b12c4e5d3ad43a292023-06-04T11:17:02ZengBMCParasites & Vectors1756-33052014-11-01711710.1186/s13071-014-0513-7A city park as a potential epidemic site of scrub typhus: a case–control study of an outbreak in Guangzhou, ChinaYuehong Wei0Lei Luo1Qinlong Jing2Xiaoning Li3Yong Huang4Xincai Xiao5Lan Liu6Xinwei Wu7Zhicong Yang8Guangzhou Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionSchool of Public Health, Guangdong Pharmaceutical UniversityGuangzhou Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionGuangzhou Center for Disease Control and PreventionAbstract Background Scrub typhus is an important public health problem in China, especially in Guangzhou city. Typical outbreaks of scrub typhus have been previously reported in rural areas, affecting mainly farmers. We describe an atypical outbreak of the disease with case fatalities, from a park in Haizhu District, Guangzhou, that could turn out to be a potential scrub typhus epidemic site. Methods From May 2012 to June 2012, a case–control study was conducted to identify source and risk factors of this outbreak. Reported cases of scrub typhus in Xiaogang Park were confirmed by Weil–Felix test or a nested polymerase chain reaction (NPCR). Controls were matched with their neighbors by gender and age. Multivariate conditional logistic regression was used to identify risk factors and protective factors. Results A total of 29 cases were confirmed by Weil–Felix test, including 4 deaths by both Weil–Felix test and NPCR. All patients presented with fever (100%), while 28 (96.6%) cases had eschars, 10 (34.5%) headache, 10 (34.5%) chills, 6 (20.7%) lymphadenopathy, 5 (17.2%) rash, 2 (6.9%) vomiting and 1 (3.5%) presented with conjunctival congestion. The proportion of cases with activity history in Xiaogang Park was much higher than the control group (72.4% vs 24.1%, P < 0.001), and morning exercise in park or field was also as a risk factor for scrub typhus (adjusted OR = 3.0, 95% CI: 1.1 - 8.2). Four factors were significantly associated with the risk of developing scrub typhus: sitting on the lawn (adjusted OR = 8.0, 95% CI: 1.4 - 44.5), close contact with rats (adjusted OR = 3.3, 95% CI: 1.2 -9.6), sitting near the rat holes (OR = 6.8, 95% CI: 1.2 - 38.1) and wearing long-sleeved clothing when outside (adjusted OR = 0.3, 95% CI: 0.1 - 0.7). Conclusions We confirmed an atypical outbreak of scrub typhus in a park in Guangzhou city, which has the potential to develop into an important epidemic site. This public health risk should not be neglected and requires more attention from authorities.https://doi.org/10.1186/s13071-014-0513-7CityParkScrub typhusEpidemiology |
| spellingShingle | Yuehong Wei Lei Luo Qinlong Jing Xiaoning Li Yong Huang Xincai Xiao Lan Liu Xinwei Wu Zhicong Yang A city park as a potential epidemic site of scrub typhus: a case–control study of an outbreak in Guangzhou, China Parasites & Vectors City Park Scrub typhus Epidemiology |
| title | A city park as a potential epidemic site of scrub typhus: a case–control study of an outbreak in Guangzhou, China |
| title_full | A city park as a potential epidemic site of scrub typhus: a case–control study of an outbreak in Guangzhou, China |
| title_fullStr | A city park as a potential epidemic site of scrub typhus: a case–control study of an outbreak in Guangzhou, China |
| title_full_unstemmed | A city park as a potential epidemic site of scrub typhus: a case–control study of an outbreak in Guangzhou, China |
| title_short | A city park as a potential epidemic site of scrub typhus: a case–control study of an outbreak in Guangzhou, China |
| title_sort | city park as a potential epidemic site of scrub typhus a case control study of an outbreak in guangzhou china |
| topic | City Park Scrub typhus Epidemiology |
| url | https://doi.org/10.1186/s13071-014-0513-7 |
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