Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release
Carboxymethyl chitosan is an important chitosan derivative with good biocompatibility and degradability, and has a wide range of biomedical applications. In this study, water-soluble carboxymethyl chitosan derivative that can be photo-crosslinked by UV irradiation was synthesized. Methacrylated carb...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | zho |
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Journal of Materials Engineering
2020-11-01
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| Series: | Cailiao gongcheng |
| Subjects: | |
| Online Access: | http://jme.biam.ac.cn/CN/10.11868/j.issn.1001-4381.2020.000025 |
| _version_ | 1797969020681453568 |
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| author | HOU Bing-na LI Jin NI Kai HAN Chao-yue SHEN Hui-ling ZHAO Lin-lin LI Zheng-zheng |
| author_facet | HOU Bing-na LI Jin NI Kai HAN Chao-yue SHEN Hui-ling ZHAO Lin-lin LI Zheng-zheng |
| author_sort | HOU Bing-na |
| collection | DOAJ |
| description | Carboxymethyl chitosan is an important chitosan derivative with good biocompatibility and degradability, and has a wide range of biomedical applications. In this study, water-soluble carboxymethyl chitosan derivative that can be photo-crosslinked by UV irradiation was synthesized. Methacrylated carboxymethyl chitosan (M-CMCS) was synthesized by N-methacrylation of carboxymethyl chitosan (CMCS). The chemical structures of M-CMCS were characterized by <sup>1</sup>H NMR and FT-IR. The M-CMCS hydrogels with different degrees of crosslinking was prepared by UV-triggered photo-crosslinking. The microscopic morphology, mechanical properties, swelling properties, enzymatic degradation properties and <i>in vitro</i> drug release behaviors of M-CMCS hydrogels were investigated by SEM, rheometer, and UV-Vis spectroscopy, respectively. The results show that the degree of methacrylation is gradually increased as the molar ratio of glycidyl methacrylate to carboxymethyl chitosan increases. M-CMCS hydrogels have the structure of high porosity and interconnected pores with the pore size of 1-20 <i>μ</i>m. The swelling ratio of M-CMCS hydrogels is decreased as the degree of crosslinking increases. M-CMCS hydrogel can be slowly degraded by lysozyme, and the degradation rate is decreased by increasing the degree of crosslinking. M-CMCS hydrogels show sustained release behavior for anticancer drug gemcitabine, and the drug release can be extended to 4 days. Photo-crosslinked M-CMCS hydrogels show great promise for drug release and tissue engineering. |
| first_indexed | 2024-04-11T02:55:34Z |
| format | Article |
| id | doaj.art-b221e39c80ca47fa8790624b1087cf24 |
| institution | Directory Open Access Journal |
| issn | 1001-4381 1001-4381 |
| language | zho |
| last_indexed | 2024-04-11T02:55:34Z |
| publishDate | 2020-11-01 |
| publisher | Journal of Materials Engineering |
| record_format | Article |
| series | Cailiao gongcheng |
| spelling | doaj.art-b221e39c80ca47fa8790624b1087cf242023-01-02T15:28:08ZzhoJournal of Materials EngineeringCailiao gongcheng1001-43811001-43812020-11-014811768410.11868/j.issn.1001-4381.2020.00002520201109Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug releaseHOU Bing-na0LI Jin1NI Kai2HAN Chao-yue3SHEN Hui-ling4ZHAO Lin-lin5LI Zheng-zheng6School of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin 300457, ChinaSchool of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin 300457, ChinaSchool of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin 300457, ChinaSchool of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin 300457, ChinaSchool of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin 300457, ChinaSchool of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300457, ChinaSchool of Chemical Engineering and Materials, Tianjin University of Science and Technology, Tianjin 300457, ChinaCarboxymethyl chitosan is an important chitosan derivative with good biocompatibility and degradability, and has a wide range of biomedical applications. In this study, water-soluble carboxymethyl chitosan derivative that can be photo-crosslinked by UV irradiation was synthesized. Methacrylated carboxymethyl chitosan (M-CMCS) was synthesized by N-methacrylation of carboxymethyl chitosan (CMCS). The chemical structures of M-CMCS were characterized by <sup>1</sup>H NMR and FT-IR. The M-CMCS hydrogels with different degrees of crosslinking was prepared by UV-triggered photo-crosslinking. The microscopic morphology, mechanical properties, swelling properties, enzymatic degradation properties and <i>in vitro</i> drug release behaviors of M-CMCS hydrogels were investigated by SEM, rheometer, and UV-Vis spectroscopy, respectively. The results show that the degree of methacrylation is gradually increased as the molar ratio of glycidyl methacrylate to carboxymethyl chitosan increases. M-CMCS hydrogels have the structure of high porosity and interconnected pores with the pore size of 1-20 <i>μ</i>m. The swelling ratio of M-CMCS hydrogels is decreased as the degree of crosslinking increases. M-CMCS hydrogel can be slowly degraded by lysozyme, and the degradation rate is decreased by increasing the degree of crosslinking. M-CMCS hydrogels show sustained release behavior for anticancer drug gemcitabine, and the drug release can be extended to 4 days. Photo-crosslinked M-CMCS hydrogels show great promise for drug release and tissue engineering.http://jme.biam.ac.cn/CN/10.11868/j.issn.1001-4381.2020.000025carboxymethyl chitosanhydrogelphoto-crosslinkingsustained drug release |
| spellingShingle | HOU Bing-na LI Jin NI Kai HAN Chao-yue SHEN Hui-ling ZHAO Lin-lin LI Zheng-zheng Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release Cailiao gongcheng carboxymethyl chitosan hydrogel photo-crosslinking sustained drug release |
| title | Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release |
| title_full | Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release |
| title_fullStr | Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release |
| title_full_unstemmed | Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release |
| title_short | Preparation of photo-crosslinking carboxymethyl chitosan hydrogel for sustained drug release |
| title_sort | preparation of photo crosslinking carboxymethyl chitosan hydrogel for sustained drug release |
| topic | carboxymethyl chitosan hydrogel photo-crosslinking sustained drug release |
| url | http://jme.biam.ac.cn/CN/10.11868/j.issn.1001-4381.2020.000025 |
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