The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease
The aim of this study was to evaluate the effect of Budesonide on the hypothalamic-pituitary-adrenal (HPA) axis in dogs with inflammatory bowel disease. The effect of orally administered Budesonide (Entocort) on the HPA axis was analysed in 21 dogs with inflammatory bowel disease. Biochemical analys...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Czech Academy of Agricultural Sciences
2017-05-01
|
| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201705-0004_the-effect-of-orally-administered-budesonide-on-the-hypothalamic-pituitary-adrenal-axis-in-dogs-with-inflammato.php |
| _version_ | 1797897539128655872 |
|---|---|
| author | A. Rychlik M. Nowicki A. Kolodziejska-Sawerska M. Szweda |
| author_facet | A. Rychlik M. Nowicki A. Kolodziejska-Sawerska M. Szweda |
| author_sort | A. Rychlik |
| collection | DOAJ |
| description | The aim of this study was to evaluate the effect of Budesonide on the hypothalamic-pituitary-adrenal (HPA) axis in dogs with inflammatory bowel disease. The effect of orally administered Budesonide (Entocort) on the HPA axis was analysed in 21 dogs with inflammatory bowel disease. Biochemical analyses were carried out to evaluate the activity levels of alanine aminotransferase, asparagine aminotransferase, alkaline phosphatase, cortisol and endogenous adrenocorticotropic hormone. Urine samples were collected from each patient before the study and after 30 days of the experiment to determine the composition and the physical and chemical properties of urine sediments. Considerably lower serum concentrations of cortisol and endogenous adrenocorticotropic hormone were observed after 30 days of treatment. A significant increase in alkaline phosphatase levels was noted on Day 30. In the studied dogs, the drop in HPA axis activity was correlated with side effects associated with the administered glucocorticosteroid (polyuria, polydipsia). In conclusion, we have shown that oral administration of Budesonide to dogs diagnosed with inflammatory bowel disease significantly suppressed the activity of the HPA axis. |
| first_indexed | 2024-04-10T07:58:52Z |
| format | Article |
| id | doaj.art-b222fd82dda54755bad5d31bd29e053e |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T07:58:52Z |
| publishDate | 2017-05-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-b222fd82dda54755bad5d31bd29e053e2023-02-23T03:50:40ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922017-05-0162526126810.17221/130/2015-VETMEDvet-201705-0004The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel diseaseA. RychlikM. Nowicki0A. Kolodziejska-Sawerska1M. Szweda2Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandFaculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandFaculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, PolandThe aim of this study was to evaluate the effect of Budesonide on the hypothalamic-pituitary-adrenal (HPA) axis in dogs with inflammatory bowel disease. The effect of orally administered Budesonide (Entocort) on the HPA axis was analysed in 21 dogs with inflammatory bowel disease. Biochemical analyses were carried out to evaluate the activity levels of alanine aminotransferase, asparagine aminotransferase, alkaline phosphatase, cortisol and endogenous adrenocorticotropic hormone. Urine samples were collected from each patient before the study and after 30 days of the experiment to determine the composition and the physical and chemical properties of urine sediments. Considerably lower serum concentrations of cortisol and endogenous adrenocorticotropic hormone were observed after 30 days of treatment. A significant increase in alkaline phosphatase levels was noted on Day 30. In the studied dogs, the drop in HPA axis activity was correlated with side effects associated with the administered glucocorticosteroid (polyuria, polydipsia). In conclusion, we have shown that oral administration of Budesonide to dogs diagnosed with inflammatory bowel disease significantly suppressed the activity of the HPA axis.https://vetmed.agriculturejournals.cz/artkey/vet-201705-0004_the-effect-of-orally-administered-budesonide-on-the-hypothalamic-pituitary-adrenal-axis-in-dogs-with-inflammato.phpglucocorticosteroidsibd treatmenteacth concentrationside effectshpa axis |
| spellingShingle | A. Rychlik M. Nowicki A. Kolodziejska-Sawerska M. Szweda The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease Veterinární Medicína glucocorticosteroids ibd treatment eacth concentration side effects hpa axis |
| title | The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease |
| title_full | The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease |
| title_fullStr | The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease |
| title_full_unstemmed | The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease |
| title_short | The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease |
| title_sort | effect of orally administered budesonide on the hypothalamic pituitary adrenal axis in dogs with inflammatory bowel disease |
| topic | glucocorticosteroids ibd treatment eacth concentration side effects hpa axis |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201705-0004_the-effect-of-orally-administered-budesonide-on-the-hypothalamic-pituitary-adrenal-axis-in-dogs-with-inflammato.php |
| work_keys_str_mv | AT arychlik theeffectoforallyadministeredbudesonideonthehypothalamicpituitaryadrenalaxisindogswithinflammatoryboweldisease AT mnowicki theeffectoforallyadministeredbudesonideonthehypothalamicpituitaryadrenalaxisindogswithinflammatoryboweldisease AT akolodziejskasawerska theeffectoforallyadministeredbudesonideonthehypothalamicpituitaryadrenalaxisindogswithinflammatoryboweldisease AT mszweda theeffectoforallyadministeredbudesonideonthehypothalamicpituitaryadrenalaxisindogswithinflammatoryboweldisease AT arychlik effectoforallyadministeredbudesonideonthehypothalamicpituitaryadrenalaxisindogswithinflammatoryboweldisease AT mnowicki effectoforallyadministeredbudesonideonthehypothalamicpituitaryadrenalaxisindogswithinflammatoryboweldisease AT akolodziejskasawerska effectoforallyadministeredbudesonideonthehypothalamicpituitaryadrenalaxisindogswithinflammatoryboweldisease AT mszweda effectoforallyadministeredbudesonideonthehypothalamicpituitaryadrenalaxisindogswithinflammatoryboweldisease |