Immune tolerance
BACKGROUND Regulation of human immune system through mechanisms of immune tolerance is an exceptionally important part of the homeostasis that protects the integrity of our organism. Whenever we talk about immune responses, we primarily consider them as an efficient activation of numerous factors en...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Slovenian Medical Association
2011-12-01
|
| Series: | Zdravniški Vestnik |
| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/550 |
| _version_ | 1811316639639011328 |
|---|---|
| author | Matjaž Jeras Urban Švajger |
| author_facet | Matjaž Jeras Urban Švajger |
| author_sort | Matjaž Jeras |
| collection | DOAJ |
| description | BACKGROUND
Regulation of human immune system through mechanisms of immune tolerance is an exceptionally important part of the homeostasis that protects the integrity of our organism. Whenever we talk about immune responses, we primarily consider them as an efficient activation of numerous factors enabling our cellular and humoral immunity to protect us against nocive effects of various forms of pathogens. However, each of these activation processes must be adequately regulated by appropriate immunosuppressive mechanisms, thereby providing a rational extent of immune reactivity without exhausting the organism and at the same time assuring a rather quick reestablishment of normal physiological conditions, which is a basic task of immune homeostasis. Such natural and dynamic »yin/yang« balance, being crucial for the wellbeing of each individual, can only be provided by well orchestrated specific interactions between activated effector immune cells, such as Th1, Th2 and Th17 CD4+ lymphocytes, CD8+ cytotoxic T lymphocytes, natural killer cells (NK) and other activating factors on one side, and the oppositely functioning immunoregulatory effectors, such as regulatory CD4+ and CD8+ T lymphocytes, tolerogenic antigen-presenting cells (APC) and other immunosuppressive factors, on the other. In the case of a colapse or an imbalance of this system, there are serious consequences that are reflected in the occurrence of autoimmune diseases, in which case the immune system is unsuccessfully suppressing the reactivity against self-antigens or the outburst of cancer cells, due to the excessive negative regulatory immune mechanisms that are actively protecting tumors. Conclusions: In this review we are presenting novel findings regarding the mechanisms of tolerance as an important part of immune homeo-self-antigens or the outburst of cancer cells, due to the excessive negative regulatory immune mechanisms that are actively protecting tumors.
CONCLUSIONS
In this review we are presenting novel findings regarding the mechanisms of tolerance as an important part of immune homeo-stasis and discussing the potential of translating this knowledge into clinical setting by developing advanced cell therapies, mostly for treating autoimmune diseases and preventing graft rejection following allogeneic tissue and organ transplantation. |
| first_indexed | 2024-04-13T11:52:59Z |
| format | Article |
| id | doaj.art-b225fc3cac5f402c9ebf5a2bfbd17b03 |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-04-13T11:52:59Z |
| publishDate | 2011-12-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-b225fc3cac5f402c9ebf5a2bfbd17b032022-12-22T02:48:00ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242011-12-018012442Immune toleranceMatjaž JerasUrban ŠvajgerBACKGROUND Regulation of human immune system through mechanisms of immune tolerance is an exceptionally important part of the homeostasis that protects the integrity of our organism. Whenever we talk about immune responses, we primarily consider them as an efficient activation of numerous factors enabling our cellular and humoral immunity to protect us against nocive effects of various forms of pathogens. However, each of these activation processes must be adequately regulated by appropriate immunosuppressive mechanisms, thereby providing a rational extent of immune reactivity without exhausting the organism and at the same time assuring a rather quick reestablishment of normal physiological conditions, which is a basic task of immune homeostasis. Such natural and dynamic »yin/yang« balance, being crucial for the wellbeing of each individual, can only be provided by well orchestrated specific interactions between activated effector immune cells, such as Th1, Th2 and Th17 CD4+ lymphocytes, CD8+ cytotoxic T lymphocytes, natural killer cells (NK) and other activating factors on one side, and the oppositely functioning immunoregulatory effectors, such as regulatory CD4+ and CD8+ T lymphocytes, tolerogenic antigen-presenting cells (APC) and other immunosuppressive factors, on the other. In the case of a colapse or an imbalance of this system, there are serious consequences that are reflected in the occurrence of autoimmune diseases, in which case the immune system is unsuccessfully suppressing the reactivity against self-antigens or the outburst of cancer cells, due to the excessive negative regulatory immune mechanisms that are actively protecting tumors. Conclusions: In this review we are presenting novel findings regarding the mechanisms of tolerance as an important part of immune homeo-self-antigens or the outburst of cancer cells, due to the excessive negative regulatory immune mechanisms that are actively protecting tumors. CONCLUSIONS In this review we are presenting novel findings regarding the mechanisms of tolerance as an important part of immune homeo-stasis and discussing the potential of translating this knowledge into clinical setting by developing advanced cell therapies, mostly for treating autoimmune diseases and preventing graft rejection following allogeneic tissue and organ transplantation.http://vestnik.szd.si/index.php/ZdravVest/article/view/550 |
| spellingShingle | Matjaž Jeras Urban Švajger Immune tolerance Zdravniški Vestnik |
| title | Immune tolerance |
| title_full | Immune tolerance |
| title_fullStr | Immune tolerance |
| title_full_unstemmed | Immune tolerance |
| title_short | Immune tolerance |
| title_sort | immune tolerance |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/550 |
| work_keys_str_mv | AT matjazjeras immunetolerance AT urbansvajger immunetolerance |