Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature review
Lymphoma rarely occurs during pregnancy, making this condition difficult to define. Lymphomas that occur in reproductive organs during pregnancy exhibit unique clinical characteristics. Among the limited cases, non-Hodgkin's lymphoma (NHL) shows a considerably higher incidence rate than Hodgkin...
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2016-09-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/961 |
| _version_ | 1811300075222073344 |
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| author | Da-Lin Gao Qian-Qian Fu Tian-Tian Zhang Lin Sun Yi Pan Qiong-Li Zhai |
| author_facet | Da-Lin Gao Qian-Qian Fu Tian-Tian Zhang Lin Sun Yi Pan Qiong-Li Zhai |
| author_sort | Da-Lin Gao |
| collection | DOAJ |
| description | Lymphoma rarely occurs during pregnancy, making this condition difficult to define. Lymphomas that occur in reproductive organs during pregnancy exhibit unique clinical characteristics. Among the limited cases, non-Hodgkin's lymphoma (NHL) shows a considerably higher incidence rate than Hodgkin's lymphoma (HL); NHL also displays clinical characteristics, such as high aggressiveness, advanced stage, and poor outcome. This study reports on four cases of lymphomas in non-gonadal organs (HL, <i>n</i>=2; NHL, <i>n</i>=2) during pregnancy. The tumors rapidly progressed in all patients during pregnancy but remitted at the end of pregnancy and/or therapy. The two HL cases were nodular sclerosis classical HL and treated with chemotherapy after terminating the pregnancy. One of the NHL cases was primary cutaneous follicular center lymphoma, a B cell-derived indolent lymphoma. The patient was followed up without any therapy after terminating her pregnancy. The other case was a follicular lymphoma grade 3B, which was treated with chemotherapy after delivery. We also conducted a literature review of 165 lymphoma cases occurring during pregnancy reported from 1976 to 2013 to reveal the correlation between pregnancy and lymphoma progression. Immunohistochemistry studies were performed to determine the expression of estrogen/progesterone receptors (ER/PR), and ER was weakly positive and sporadic. We concluded that lymphomas occurring during pregnancy should be managed with a prompt and reasonable treatment. High estrogen level in maternal body may affect lymphoma progression. |
| first_indexed | 2024-04-13T06:45:57Z |
| format | Article |
| id | doaj.art-b2298d616c3d43028d657ea8728395ff |
| institution | Directory Open Access Journal |
| issn | 2095-3941 2095-3941 |
| language | English |
| last_indexed | 2024-04-13T06:45:57Z |
| publishDate | 2016-09-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-b2298d616c3d43028d657ea8728395ff2022-12-22T02:57:35ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412016-09-0113339940310.20892/j.issn.2095-3941.2016.00402016000040Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature reviewDa-Lin Gao0Qian-Qian Fu1Tian-Tian Zhang2Lin Sun3Yi Pan4Qiong-Li Zhai5Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaDepartment of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaDepartment of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaDepartment of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaDepartment of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaDepartment of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaLymphoma rarely occurs during pregnancy, making this condition difficult to define. Lymphomas that occur in reproductive organs during pregnancy exhibit unique clinical characteristics. Among the limited cases, non-Hodgkin's lymphoma (NHL) shows a considerably higher incidence rate than Hodgkin's lymphoma (HL); NHL also displays clinical characteristics, such as high aggressiveness, advanced stage, and poor outcome. This study reports on four cases of lymphomas in non-gonadal organs (HL, <i>n</i>=2; NHL, <i>n</i>=2) during pregnancy. The tumors rapidly progressed in all patients during pregnancy but remitted at the end of pregnancy and/or therapy. The two HL cases were nodular sclerosis classical HL and treated with chemotherapy after terminating the pregnancy. One of the NHL cases was primary cutaneous follicular center lymphoma, a B cell-derived indolent lymphoma. The patient was followed up without any therapy after terminating her pregnancy. The other case was a follicular lymphoma grade 3B, which was treated with chemotherapy after delivery. We also conducted a literature review of 165 lymphoma cases occurring during pregnancy reported from 1976 to 2013 to reveal the correlation between pregnancy and lymphoma progression. Immunohistochemistry studies were performed to determine the expression of estrogen/progesterone receptors (ER/PR), and ER was weakly positive and sporadic. We concluded that lymphomas occurring during pregnancy should be managed with a prompt and reasonable treatment. High estrogen level in maternal body may affect lymphoma progression.http://www.cancerbiomed.org/index.php/cocr/article/view/961Lymphomapregnancyestrogenestrogen receptor βBCL2 |
| spellingShingle | Da-Lin Gao Qian-Qian Fu Tian-Tian Zhang Lin Sun Yi Pan Qiong-Li Zhai Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature review Cancer Biology & Medicine Lymphoma pregnancy estrogen estrogen receptor β BCL2 |
| title | Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature review |
| title_full | Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature review |
| title_fullStr | Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature review |
| title_full_unstemmed | Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature review |
| title_short | Occurrence of lymphoma in non-gonadal organ during pregnancy: a report on four cases and literature review |
| title_sort | occurrence of lymphoma in non gonadal organ during pregnancy a report on four cases and literature review |
| topic | Lymphoma pregnancy estrogen estrogen receptor β BCL2 |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/961 |
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