Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trial
Objective: The effect of lavender syrup on COVID-19-induced olfactory dysfunction (OD) has been assessed in this study.Materials and Methods: This pilot clinical trial was conducted in Gonbad-E-Kavoos (Golestan province, Iran). Twenty-three outpatients with COVID-19 and OD in lavender group took 9 m...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-01-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_18420_3706fd9e905539bfa7be058f79b2c583.pdf |
| _version_ | 1818969432978882560 |
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| author | Fataneh Hashem-Dabaghian Sadegh Ali Azimi Mohsen Bahrami Seied-Amirhossein Latifi Ayesheh Enayati Marzieh Qaraaty |
| author_facet | Fataneh Hashem-Dabaghian Sadegh Ali Azimi Mohsen Bahrami Seied-Amirhossein Latifi Ayesheh Enayati Marzieh Qaraaty |
| author_sort | Fataneh Hashem-Dabaghian |
| collection | DOAJ |
| description | Objective: The effect of lavender syrup on COVID-19-induced olfactory dysfunction (OD) has been assessed in this study.Materials and Methods: This pilot clinical trial was conducted in Gonbad-E-Kavoos (Golestan province, Iran). Twenty-three outpatients with COVID-19 and OD in lavender group took 9 ml of lavender syrup/bid for 3 weeks along with the standard COVID-19 treatments and 20 patients in control group took only standard COVID-19 treatments. The severity of OD was assessed by the visual analogue scale (VAS). Data analysis was performed by Friedman and Mann-Whitney tests using SPSS software.Results: The mean± standard deviation of age was 36.6±9.1, and 42.6±10.4 years (p=0.05), and the duration of symptoms was 7.4±3.5, and 7.5±3.4 days (p=0.98) in the lavender and control group, respectively. The VAS score for OD decreased from 6.8±3.04 to 0.26±0.86 in the lavender group and from 5.3±3.4 to 1±2.61 in the control group. Although, VAS for OD was significantly decreased in both groups (p<0.001), the amount of VAS decrease was 6.6±2.9 scores in the lavender group, and 4.3±4 in the control group (p=0.03). No side effects were observed in the lavender group.Conclusion: The present study showed that lavender syrup is an effective treatment for COVID-19-induced OD. It is suggested to conduct further studies with larger sample size. |
| first_indexed | 2024-12-20T14:20:30Z |
| format | Article |
| id | doaj.art-b22c59ef1d9041fc961b13148bdf1d54 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-20T14:20:30Z |
| publishDate | 2022-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-b22c59ef1d9041fc961b13148bdf1d542022-12-21T19:37:56ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492022-01-011211710.22038/ajp.2021.1842018420Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trialFataneh Hashem-Dabaghian0Sadegh Ali Azimi1Mohsen Bahrami2Seied-Amirhossein Latifi3Ayesheh Enayati4Marzieh Qaraaty5Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, IranInfectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, IranResearcher of Persian Medicine, Tehran, IranTraditional and Complementary Medicine Research Center, Faculty of Medicine, Arak University of Medical Sciences, Arak, IranIschemic research Center, Golestan University of Medical Sciences, Gorgan, IranClinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, IranObjective: The effect of lavender syrup on COVID-19-induced olfactory dysfunction (OD) has been assessed in this study.Materials and Methods: This pilot clinical trial was conducted in Gonbad-E-Kavoos (Golestan province, Iran). Twenty-three outpatients with COVID-19 and OD in lavender group took 9 ml of lavender syrup/bid for 3 weeks along with the standard COVID-19 treatments and 20 patients in control group took only standard COVID-19 treatments. The severity of OD was assessed by the visual analogue scale (VAS). Data analysis was performed by Friedman and Mann-Whitney tests using SPSS software.Results: The mean± standard deviation of age was 36.6±9.1, and 42.6±10.4 years (p=0.05), and the duration of symptoms was 7.4±3.5, and 7.5±3.4 days (p=0.98) in the lavender and control group, respectively. The VAS score for OD decreased from 6.8±3.04 to 0.26±0.86 in the lavender group and from 5.3±3.4 to 1±2.61 in the control group. Although, VAS for OD was significantly decreased in both groups (p<0.001), the amount of VAS decrease was 6.6±2.9 scores in the lavender group, and 4.3±4 in the control group (p=0.03). No side effects were observed in the lavender group.Conclusion: The present study showed that lavender syrup is an effective treatment for COVID-19-induced OD. It is suggested to conduct further studies with larger sample size.https://ajp.mums.ac.ir/article_18420_3706fd9e905539bfa7be058f79b2c583.pdfcovid-19anosmiaherbal medicinelavendulapersian medicine |
| spellingShingle | Fataneh Hashem-Dabaghian Sadegh Ali Azimi Mohsen Bahrami Seied-Amirhossein Latifi Ayesheh Enayati Marzieh Qaraaty Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trial Avicenna Journal of Phytomedicine covid-19 anosmia herbal medicine lavendula persian medicine |
| title | Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trial |
| title_full | Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trial |
| title_fullStr | Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trial |
| title_full_unstemmed | Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trial |
| title_short | Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trial |
| title_sort | effect of lavender lavandula angustifolia l syrup on olfactory dysfunction in covid 19 infection a pilot controlled clinical trial |
| topic | covid-19 anosmia herbal medicine lavendula persian medicine |
| url | https://ajp.mums.ac.ir/article_18420_3706fd9e905539bfa7be058f79b2c583.pdf |
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