Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis
Environmentally, bisphenol A (BPA) is a well-known pollutant caused human health risk, including osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. However, the anti-OS pharmacotherapy prescribes limitedly in clinical practice. Interestingly, previous experimental evid...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
|
| Series: | Bioengineered |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21655979.2021.1956401 |
| _version_ | 1798033996892864512 |
|---|---|
| author | Qijin Pan Ka Wu Jiachang Tan Yu Li Xiao Liang Min Su |
| author_facet | Qijin Pan Ka Wu Jiachang Tan Yu Li Xiao Liang Min Su |
| author_sort | Qijin Pan |
| collection | DOAJ |
| description | Environmentally, bisphenol A (BPA) is a well-known pollutant caused human health risk, including osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. However, the anti-OS pharmacotherapy prescribes limitedly in clinical practice. Interestingly, previous experimental evidences indicate calycosin-exerting potential anti-OS actions. Thus, in this report, we aimed to further characterize and detail the therapeutic targets and molecular mechanisms of calycosin-anti-BPA-related OS by using network pharmacology and molecular docking analyses. In results, the bioinformatics data disclosed all mapped, core targets, biological functions, molecular pathways of calycosin to treat BPA-related OS. The computational analysis using molecular docking indicated that potential binding ability of core targets in calycosin to treat BPA-related OS was identified. Moreover, detailed biological functions and optimal pathways of calycosin-anti-BPA-related OS were revealed, as shown in integrated network maps. Taken together, these network pharmacology and structural biology findings illustrate the core biotargets, pharmacological functions and pathways of calycosin-anti-BPA-related OS. Potentially, these core targets identified by molecular docking may attribute to the potential clinical application of calycosin against BPA-related OS. |
| first_indexed | 2024-04-11T20:38:08Z |
| format | Article |
| id | doaj.art-b22c98b442404cfcb745ff3dcf8ae13f |
| institution | Directory Open Access Journal |
| issn | 2165-5979 2165-5987 |
| language | English |
| last_indexed | 2024-04-11T20:38:08Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Bioengineered |
| spelling | doaj.art-b22c98b442404cfcb745ff3dcf8ae13f2022-12-22T04:04:18ZengTaylor & Francis GroupBioengineered2165-59792165-59872021-01-011214278428810.1080/21655979.2021.19564011956401Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysisQijin Pan0Ka Wu1Jiachang Tan2Yu Li3Xiao Liang4Min Su5Guigang City Peoples’ Hospital, The Eighth Affiliated Hospital of Guangxi Medical UniversityThe Second People’s Hospital of Nanning City, the Third Affiliated Hospital of Guangxi Medical UniversityAffiliated Tumor Hospital, Guangxi Medical UniversityGuilin Medical UniversityGuilin Medical UniversityGuilin Medical UniversityEnvironmentally, bisphenol A (BPA) is a well-known pollutant caused human health risk, including osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. However, the anti-OS pharmacotherapy prescribes limitedly in clinical practice. Interestingly, previous experimental evidences indicate calycosin-exerting potential anti-OS actions. Thus, in this report, we aimed to further characterize and detail the therapeutic targets and molecular mechanisms of calycosin-anti-BPA-related OS by using network pharmacology and molecular docking analyses. In results, the bioinformatics data disclosed all mapped, core targets, biological functions, molecular pathways of calycosin to treat BPA-related OS. The computational analysis using molecular docking indicated that potential binding ability of core targets in calycosin to treat BPA-related OS was identified. Moreover, detailed biological functions and optimal pathways of calycosin-anti-BPA-related OS were revealed, as shown in integrated network maps. Taken together, these network pharmacology and structural biology findings illustrate the core biotargets, pharmacological functions and pathways of calycosin-anti-BPA-related OS. Potentially, these core targets identified by molecular docking may attribute to the potential clinical application of calycosin against BPA-related OS.http://dx.doi.org/10.1080/21655979.2021.1956401osteosarcomabisphenol acalycosinnetwork pharmacologymolecular dockingfindings |
| spellingShingle | Qijin Pan Ka Wu Jiachang Tan Yu Li Xiao Liang Min Su Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis Bioengineered osteosarcoma bisphenol a calycosin network pharmacology molecular docking findings |
| title | Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis |
| title_full | Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis |
| title_fullStr | Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis |
| title_full_unstemmed | Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis |
| title_short | Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis |
| title_sort | anti neoplastic characteristics and potential targets of calycosin against bisphenol a related osteosarcoma bioinformatics analysis |
| topic | osteosarcoma bisphenol a calycosin network pharmacology molecular docking findings |
| url | http://dx.doi.org/10.1080/21655979.2021.1956401 |
| work_keys_str_mv | AT qijinpan antineoplasticcharacteristicsandpotentialtargetsofcalycosinagainstbisphenolarelatedosteosarcomabioinformaticsanalysis AT kawu antineoplasticcharacteristicsandpotentialtargetsofcalycosinagainstbisphenolarelatedosteosarcomabioinformaticsanalysis AT jiachangtan antineoplasticcharacteristicsandpotentialtargetsofcalycosinagainstbisphenolarelatedosteosarcomabioinformaticsanalysis AT yuli antineoplasticcharacteristicsandpotentialtargetsofcalycosinagainstbisphenolarelatedosteosarcomabioinformaticsanalysis AT xiaoliang antineoplasticcharacteristicsandpotentialtargetsofcalycosinagainstbisphenolarelatedosteosarcomabioinformaticsanalysis AT minsu antineoplasticcharacteristicsandpotentialtargetsofcalycosinagainstbisphenolarelatedosteosarcomabioinformaticsanalysis |