Molecular Characterization of TMPRSS2-ERG Gene Fusion in the NCI-H660 Prostate Cancer Cell Line: A New Perspective for an Old Model

Molecular Characterization of TMPRSS2-ERG Gene Fusion in the NCI-H660 Prostate Cancer Cell Line: A New Perspective for an Old Model

Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG. Studies on the molecular mechanisms and functional consequences of this i...

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Bibliographic Details
Main Authors: Kirsten D. Mertz, Sunita R. Setlur, Saravana M. Dhanasekaran, Francesca Demichelis, Sven Perner, Scott Tomlins, Joëlle Tchinda, Bharathi Laxman, Robert L. Vessella, Rameen Beroukhimt, Charles Lee, Arul M. Chinnaiyan, Mark A. Rubin
Format: Article
Language:English
Published: Elsevier 2007-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TMPRSS2-ERG
prostate cancer
cell line
gene fusion
translocation
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800510

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