Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study
Objective: This study investigated the association of metabolic syndrome (MS) and its components with cardiac, macro-, and micro-circulatory abnormalities in an elderly Chinese population.Methods: This cross-sectional study was conducted using data for 1,958 participants from the Northern Shanghai S...
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| Format: | Article |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.690521/full |
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| author | Fang Zhao Rong Yang Rusitanmujiang Maimaitiaili Jiamin Tang Song Zhao Jing Xiong Jiadela Teliewubai Chen Chi Jacques Blacher Jue Li Yawei Xu Yan Jiang Yi Zhang Weiming Li |
| author_facet | Fang Zhao Rong Yang Rusitanmujiang Maimaitiaili Jiamin Tang Song Zhao Jing Xiong Jiadela Teliewubai Chen Chi Jacques Blacher Jue Li Yawei Xu Yan Jiang Yi Zhang Weiming Li |
| author_sort | Fang Zhao |
| collection | DOAJ |
| description | Objective: This study investigated the association of metabolic syndrome (MS) and its components with cardiac, macro-, and micro-circulatory abnormalities in an elderly Chinese population.Methods: This cross-sectional study was conducted using data for 1,958 participants from the Northern Shanghai Study aged over 65 years without a history of cardiovascular disease. MS was defined according to the National Cholesterol Education Program Adult Treatment Panel III in 2005 (NCEPIII 2005). Asymptomatic cardiovascular impairment parameters, including the left ventricle mass index (LVMI), peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid-femoral pulse wave velocity (cf-PWV), ankle-brachial index (ABI), carotid intima-media thickness (CIMT), arterial plaque, and urinary albumin–creatinine rate (UACR), were evaluated.Results: LVMI, E/Ea, cf-PWV, and the proportion of UACR > 30 mg/g exhibited increasing trends while ABI exhibited a decreasing trend according to the number of MS components (all p for trend < 0.01). Logistic regression analysis revealed that MS was significantly associated with LV hypertrophy (LVH), LV diastolic dysfunction, arteriosclerosis, and microalbuminuria (all p < 0.001). Central obesity and high blood pressure were associated with all cardiovascular abnormalities (all p < 0.05), whereas elevated plasma glucose was associated with arteriosclerosis and microalbuminuria (both p < 0.001). In addition, high triglyceride levels were associated with microalbuminuria (p < 0.05).Conclusions: MS is significantly associated with cardiac, macro-, and micro-circulatory abnormalities in elderly Chinese. Moreover, the presence of individual MS components may have specific prognostic significance. |
| first_indexed | 2024-12-21T05:29:57Z |
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| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-21T05:29:57Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b2315e601d0640d3aeb22a8cd98263b72022-12-21T19:14:34ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-07-01810.3389/fcvm.2021.690521690521Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai StudyFang Zhao0Rong Yang1Rusitanmujiang Maimaitiaili2Jiamin Tang3Song Zhao4Jing Xiong5Jiadela Teliewubai6Chen Chi7Jacques Blacher8Jue Li9Yawei Xu10Yan Jiang11Yi Zhang12Weiming Li13Department of Geriatrics, Shanghai Putuo People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Geriatrics, Shanghai Putuo People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaParis Descartes University, AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris, FranceInstitute of Clinical Epidemiology and Evidence-Based Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Geriatrics, Shanghai Putuo People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, ChinaObjective: This study investigated the association of metabolic syndrome (MS) and its components with cardiac, macro-, and micro-circulatory abnormalities in an elderly Chinese population.Methods: This cross-sectional study was conducted using data for 1,958 participants from the Northern Shanghai Study aged over 65 years without a history of cardiovascular disease. MS was defined according to the National Cholesterol Education Program Adult Treatment Panel III in 2005 (NCEPIII 2005). Asymptomatic cardiovascular impairment parameters, including the left ventricle mass index (LVMI), peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid-femoral pulse wave velocity (cf-PWV), ankle-brachial index (ABI), carotid intima-media thickness (CIMT), arterial plaque, and urinary albumin–creatinine rate (UACR), were evaluated.Results: LVMI, E/Ea, cf-PWV, and the proportion of UACR > 30 mg/g exhibited increasing trends while ABI exhibited a decreasing trend according to the number of MS components (all p for trend < 0.01). Logistic regression analysis revealed that MS was significantly associated with LV hypertrophy (LVH), LV diastolic dysfunction, arteriosclerosis, and microalbuminuria (all p < 0.001). Central obesity and high blood pressure were associated with all cardiovascular abnormalities (all p < 0.05), whereas elevated plasma glucose was associated with arteriosclerosis and microalbuminuria (both p < 0.001). In addition, high triglyceride levels were associated with microalbuminuria (p < 0.05).Conclusions: MS is significantly associated with cardiac, macro-, and micro-circulatory abnormalities in elderly Chinese. Moreover, the presence of individual MS components may have specific prognostic significance.https://www.frontiersin.org/articles/10.3389/fcvm.2021.690521/fullelderly populationcardiac abnormalitymacrocirculatory abnormalitymicrocirculatory abnormalitymetabolic syndrome |
| spellingShingle | Fang Zhao Rong Yang Rusitanmujiang Maimaitiaili Jiamin Tang Song Zhao Jing Xiong Jiadela Teliewubai Chen Chi Jacques Blacher Jue Li Yawei Xu Yan Jiang Yi Zhang Weiming Li Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study Frontiers in Cardiovascular Medicine elderly population cardiac abnormality macrocirculatory abnormality microcirculatory abnormality metabolic syndrome |
| title | Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study |
| title_full | Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study |
| title_fullStr | Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study |
| title_full_unstemmed | Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study |
| title_short | Cardiac, Macro-, and Micro-Circulatory Abnormalities in Association With Individual Metabolic Syndrome Component: The Northern Shanghai Study |
| title_sort | cardiac macro and micro circulatory abnormalities in association with individual metabolic syndrome component the northern shanghai study |
| topic | elderly population cardiac abnormality macrocirculatory abnormality microcirculatory abnormality metabolic syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.690521/full |
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