Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis
This original article presents the findings of a comprehensive case series, shedding light on the efficacy of diverse treatment modalities for managing precancerous and cancerous skin lesions and their remarkable rejuvenation effects on the skin. A particular focus is placed on the promising outcome...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Cosmetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9284/11/1/3 |
| _version_ | 1797298574542766080 |
|---|---|
| author | Nadia Sciamarrelli François Rosset Sara Boskovic Silvia Borriello Luca Mastorino Simone Ribero Pietro Quaglino Paolo Broganelli |
| author_facet | Nadia Sciamarrelli François Rosset Sara Boskovic Silvia Borriello Luca Mastorino Simone Ribero Pietro Quaglino Paolo Broganelli |
| author_sort | Nadia Sciamarrelli |
| collection | DOAJ |
| description | This original article presents the findings of a comprehensive case series, shedding light on the efficacy of diverse treatment modalities for managing precancerous and cancerous skin lesions and their remarkable rejuvenation effects on the skin. A particular focus is placed on the promising outcomes achieved through the application of a combination treatment involving 5-Fluorouracil (5-FU) and salicylic acid, which demonstrates enduring and noteworthy results. Furthermore, alternative therapeutic approaches, including 5-FU monotherapy, Methyl aminolevulinate–photodynamic therapy (MAL-PDT), and the combination of Imiquimod therapy with MAL-PDT, exhibit substantial potential for patients seeking non-surgical solutions. These treatments manifest as valuable tools in improving skin texture and mitigating the effects of photodamage. Nevertheless, the intricate interplay between the chosen treatment, the extent of photodamage, and individual patient characteristics, with a particular emphasis on age, necessitates long-term follow-up to gauge treatment outcomes and the likelihood of lesion recurrence. Notably, these treatments are associated with a significant degree of inflammation, igniting curiosity regarding enhanced skin cellular turnover and the potential for a more youthful skin appearance. Our findings accentuate the promise of topical fluorouracil (5-FU) and photodynamic therapy (PDT) in combating photoaging among patients with actinic keratoses. However, a need for further in-depth research is evident to unravel the nuanced relationships between these treatments, the severity of photodamage, and the influence of patient-specific factors. Such comprehensive investigations are instrumental in optimizing patient care and outcomes, offering a holistic approach to managing photodamage within the context of actinic keratoses. This work, when combined with existing literature, provides valuable insights and serves as a catalyst for future research to fully unlock the potential of these treatments, ultimately enhancing the quality of patient care. |
| first_indexed | 2024-03-07T22:36:47Z |
| format | Article |
| id | doaj.art-b2318e64f47d45579ec9c4dfb2606b8b |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-07T22:36:47Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-b2318e64f47d45579ec9c4dfb2606b8b2024-02-23T15:12:58ZengMDPI AGCosmetics2079-92842023-12-01111310.3390/cosmetics11010003Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series AnalysisNadia Sciamarrelli0François Rosset1Sara Boskovic2Silvia Borriello3Luca Mastorino4Simone Ribero5Pietro Quaglino6Paolo Broganelli7Department of Medical Sciences, Section of Dermatology, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Section of Dermatology, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Section of Dermatology, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Section of Dermatology, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Section of Dermatology, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Section of Dermatology, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Section of Dermatology, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, Section of Dermatology, University of Turin, 10126 Turin, ItalyThis original article presents the findings of a comprehensive case series, shedding light on the efficacy of diverse treatment modalities for managing precancerous and cancerous skin lesions and their remarkable rejuvenation effects on the skin. A particular focus is placed on the promising outcomes achieved through the application of a combination treatment involving 5-Fluorouracil (5-FU) and salicylic acid, which demonstrates enduring and noteworthy results. Furthermore, alternative therapeutic approaches, including 5-FU monotherapy, Methyl aminolevulinate–photodynamic therapy (MAL-PDT), and the combination of Imiquimod therapy with MAL-PDT, exhibit substantial potential for patients seeking non-surgical solutions. These treatments manifest as valuable tools in improving skin texture and mitigating the effects of photodamage. Nevertheless, the intricate interplay between the chosen treatment, the extent of photodamage, and individual patient characteristics, with a particular emphasis on age, necessitates long-term follow-up to gauge treatment outcomes and the likelihood of lesion recurrence. Notably, these treatments are associated with a significant degree of inflammation, igniting curiosity regarding enhanced skin cellular turnover and the potential for a more youthful skin appearance. Our findings accentuate the promise of topical fluorouracil (5-FU) and photodynamic therapy (PDT) in combating photoaging among patients with actinic keratoses. However, a need for further in-depth research is evident to unravel the nuanced relationships between these treatments, the severity of photodamage, and the influence of patient-specific factors. Such comprehensive investigations are instrumental in optimizing patient care and outcomes, offering a holistic approach to managing photodamage within the context of actinic keratoses. This work, when combined with existing literature, provides valuable insights and serves as a catalyst for future research to fully unlock the potential of these treatments, ultimately enhancing the quality of patient care.https://www.mdpi.com/2079-9284/11/1/3skin rejuvenationactinic keratosisNMSC5-fluorouracilMAL-PDT |
| spellingShingle | Nadia Sciamarrelli François Rosset Sara Boskovic Silvia Borriello Luca Mastorino Simone Ribero Pietro Quaglino Paolo Broganelli Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis Cosmetics skin rejuvenation actinic keratosis NMSC 5-fluorouracil MAL-PDT |
| title | Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis |
| title_full | Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis |
| title_fullStr | Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis |
| title_full_unstemmed | Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis |
| title_short | Simultaneous Skin Rejuvenation in Patients Undergoing Medical Treatment for Actinic Keratosis and Non-Melanoma Skin Cancer: A Case Series Analysis |
| title_sort | simultaneous skin rejuvenation in patients undergoing medical treatment for actinic keratosis and non melanoma skin cancer a case series analysis |
| topic | skin rejuvenation actinic keratosis NMSC 5-fluorouracil MAL-PDT |
| url | https://www.mdpi.com/2079-9284/11/1/3 |
| work_keys_str_mv | AT nadiasciamarrelli simultaneousskinrejuvenationinpatientsundergoingmedicaltreatmentforactinickeratosisandnonmelanomaskincanceracaseseriesanalysis AT francoisrosset simultaneousskinrejuvenationinpatientsundergoingmedicaltreatmentforactinickeratosisandnonmelanomaskincanceracaseseriesanalysis AT saraboskovic simultaneousskinrejuvenationinpatientsundergoingmedicaltreatmentforactinickeratosisandnonmelanomaskincanceracaseseriesanalysis AT silviaborriello simultaneousskinrejuvenationinpatientsundergoingmedicaltreatmentforactinickeratosisandnonmelanomaskincanceracaseseriesanalysis AT lucamastorino simultaneousskinrejuvenationinpatientsundergoingmedicaltreatmentforactinickeratosisandnonmelanomaskincanceracaseseriesanalysis AT simoneribero simultaneousskinrejuvenationinpatientsundergoingmedicaltreatmentforactinickeratosisandnonmelanomaskincanceracaseseriesanalysis AT pietroquaglino simultaneousskinrejuvenationinpatientsundergoingmedicaltreatmentforactinickeratosisandnonmelanomaskincanceracaseseriesanalysis AT paolobroganelli simultaneousskinrejuvenationinpatientsundergoingmedicaltreatmentforactinickeratosisandnonmelanomaskincanceracaseseriesanalysis |