Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study
Abstract Background Sarcopenia has been associated with adverse outcomes in patients with chronic kidney disease (CKD), particularly in those undergoing hemodialysis (HD). However, the trajectories across sarcopenia stages, their determinants, and associations with adverse clinical outcomes have yet...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-023-03168-4 |
| _version_ | 1797453628187869184 |
|---|---|
| author | Marvery P. Duarte Marina S. Pereira Victor M. Baião Fábio A. Vieira Maryanne Zilli Canedo Silva Rodrigo R. Krug Antônio J. Inda-Filho Aparecido P. Ferreira Ricardo M. Lima Carla Maria Avesani Otávio T. Nóbrega Maycon M. Reboredo Heitor S. Ribeiro on behalf of the SARC-HD Study Group |
| author_facet | Marvery P. Duarte Marina S. Pereira Victor M. Baião Fábio A. Vieira Maryanne Zilli Canedo Silva Rodrigo R. Krug Antônio J. Inda-Filho Aparecido P. Ferreira Ricardo M. Lima Carla Maria Avesani Otávio T. Nóbrega Maycon M. Reboredo Heitor S. Ribeiro on behalf of the SARC-HD Study Group |
| author_sort | Marvery P. Duarte |
| collection | DOAJ |
| description | Abstract Background Sarcopenia has been associated with adverse outcomes in patients with chronic kidney disease (CKD), particularly in those undergoing hemodialysis (HD). However, the trajectories across sarcopenia stages, their determinants, and associations with adverse clinical outcomes have yet to be comprehensively examined. Methods The SARC-HD is a multicenter, observational prospective cohort study designed to comprehensively investigate sarcopenia in patients on HD. Eligibility criteria include adult patients undergoing HD for ≥ 3 months. The primary objective is to investigate the trajectories of sarcopenia stages and their potential determinants. Secondary objectives include evaluating the association between sarcopenia and adverse clinical outcomes (i.e., falls, hospitalization, and mortality). Sarcopenia risk will be assessed by the SARC-F and SARC-CalF questionnaire. Sarcopenia traits (i.e., low muscle strength, low muscle mass, and low physical performance) will be defined according to the revised European Working Group on Sarcopenia in Older People and will be assessed at baseline and after 12 follow-up months. Patients will be followed-up at 3 monthly intervals for adverse clinical outcomes during 24 months. Discussion Collectively, we expect to provide relevant clinical findings for healthcare professionals from nephrology on the association between sarcopenia screening tools (i.e., SARC-F and SARC-CalF) with objective sarcopenia measurements, as well as to investigate predictors of trajectories across sarcopenia stages, and the impact of sarcopenia on adverse clinical outcomes. Hence, our ambition is that the data acquired from SARC-HD study will provide novel and valuable evidence to support an adequate screening and management of sarcopenia in patients on HD. |
| first_indexed | 2024-03-09T15:25:34Z |
| format | Article |
| id | doaj.art-b231bef2af384dfea04b6e18adb678ef |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-03-09T15:25:34Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-b231bef2af384dfea04b6e18adb678ef2023-11-26T12:35:15ZengBMCBMC Nephrology1471-23692023-08-0124111210.1186/s12882-023-03168-4Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD studyMarvery P. Duarte0Marina S. Pereira1Victor M. Baião2Fábio A. Vieira3Maryanne Zilli Canedo Silva4Rodrigo R. Krug5Antônio J. Inda-Filho6Aparecido P. Ferreira7Ricardo M. Lima8Carla Maria Avesani9Otávio T. Nóbrega10Maycon M. Reboredo11Heitor S. Ribeiro12on behalf of the SARC-HD Study GroupFaculty of Health Sciences, University of BrasiliaPulmonary and Critical Care Division, University Hospital of Federal University of Juiz de ForaFaculty of Health Sciences, University of BrasiliaIdealCor PhysiotherapyInternal Medicine Department, Botucatu Medical School, São Paulo State University, UNESPUniversity of Cruz AltaInterdisciplinary Research Department, University Center ICESPInterdisciplinary Research Department, University Center ICESPFaculty of Physical Education, University of BrasiliaDepartment of Clinical Science, Technology and Intervention, Division of Renal Medicine and Baxter Novum, Karolinska InstituteFaculty of Health Sciences, University of BrasiliaPulmonary and Critical Care Division, University Hospital of Federal University of Juiz de ForaFaculty of Health Sciences, University of BrasiliaAbstract Background Sarcopenia has been associated with adverse outcomes in patients with chronic kidney disease (CKD), particularly in those undergoing hemodialysis (HD). However, the trajectories across sarcopenia stages, their determinants, and associations with adverse clinical outcomes have yet to be comprehensively examined. Methods The SARC-HD is a multicenter, observational prospective cohort study designed to comprehensively investigate sarcopenia in patients on HD. Eligibility criteria include adult patients undergoing HD for ≥ 3 months. The primary objective is to investigate the trajectories of sarcopenia stages and their potential determinants. Secondary objectives include evaluating the association between sarcopenia and adverse clinical outcomes (i.e., falls, hospitalization, and mortality). Sarcopenia risk will be assessed by the SARC-F and SARC-CalF questionnaire. Sarcopenia traits (i.e., low muscle strength, low muscle mass, and low physical performance) will be defined according to the revised European Working Group on Sarcopenia in Older People and will be assessed at baseline and after 12 follow-up months. Patients will be followed-up at 3 monthly intervals for adverse clinical outcomes during 24 months. Discussion Collectively, we expect to provide relevant clinical findings for healthcare professionals from nephrology on the association between sarcopenia screening tools (i.e., SARC-F and SARC-CalF) with objective sarcopenia measurements, as well as to investigate predictors of trajectories across sarcopenia stages, and the impact of sarcopenia on adverse clinical outcomes. Hence, our ambition is that the data acquired from SARC-HD study will provide novel and valuable evidence to support an adequate screening and management of sarcopenia in patients on HD.https://doi.org/10.1186/s12882-023-03168-4Chronic kidney diseaseDialysisSarcopeniaSARC-FPhysical function |
| spellingShingle | Marvery P. Duarte Marina S. Pereira Victor M. Baião Fábio A. Vieira Maryanne Zilli Canedo Silva Rodrigo R. Krug Antônio J. Inda-Filho Aparecido P. Ferreira Ricardo M. Lima Carla Maria Avesani Otávio T. Nóbrega Maycon M. Reboredo Heitor S. Ribeiro on behalf of the SARC-HD Study Group Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study BMC Nephrology Chronic kidney disease Dialysis Sarcopenia SARC-F Physical function |
| title | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
| title_full | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
| title_fullStr | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
| title_full_unstemmed | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
| title_short | Design and methodology of the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis: the SARC-HD study |
| title_sort | design and methodology of the sarcopenia trajectories and associations with adverse clinical outcomes in patients on hemodialysis the sarc hd study |
| topic | Chronic kidney disease Dialysis Sarcopenia SARC-F Physical function |
| url | https://doi.org/10.1186/s12882-023-03168-4 |
| work_keys_str_mv | AT marverypduarte designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT marinaspereira designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT victormbaiao designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT fabioavieira designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT maryannezillicanedosilva designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT rodrigorkrug designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT antoniojindafilho designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT aparecidopferreira designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT ricardomlima designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT carlamariaavesani designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT otaviotnobrega designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT mayconmreboredo designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT heitorsribeiro designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy AT onbehalfofthesarchdstudygroup designandmethodologyofthesarcopeniatrajectoriesandassociationswithadverseclinicaloutcomesinpatientsonhemodialysisthesarchdstudy |