A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells
Abstract Tissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical practices. This elegant approach utilizes a natural/synthetic biomaterial with optimized physiomechanical properties to serve as a vehicle for delivery of exogenous stem cells...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-06-01
|
| Series: | International Journal of Oral Science |
| Online Access: | https://doi.org/10.1038/s41368-021-00126-4 |
| _version_ | 1818741115399962624 |
|---|---|
| author | Sevda Pouraghaei Sevari Sahar Ansari Alireza Moshaverinia |
| author_facet | Sevda Pouraghaei Sevari Sahar Ansari Alireza Moshaverinia |
| author_sort | Sevda Pouraghaei Sevari |
| collection | DOAJ |
| description | Abstract Tissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical practices. This elegant approach utilizes a natural/synthetic biomaterial with optimized physiomechanical properties to serve as a vehicle for delivery of exogenous stem cells and bioactive factors or induce local recruitment of endogenous cells for in situ tissue regeneration. Inspired by the natural microenvironment, biomaterials could act as a biomimetic three-dimensional (3D) structure to help the cells establish their natural interactions. Such a strategy should not only employ a biocompatible biomaterial to induce new tissue formation but also benefit from an easily accessible and abundant source of stem cells with potent tissue regenerative potential. The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs) with self-renewing and multilineage differentiation capabilities. In the current review article, we seek to highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches, cell transplantation and cell homing. Altogether, this paper develops a general picture of current innovative strategies to employ dental-derived MSCs combined with biomaterials and bioactive factors for regenerating the lost or defective tissues and offers information regarding the available scientific data and possible applications. |
| first_indexed | 2024-12-18T01:51:29Z |
| format | Article |
| id | doaj.art-b23259c9f69f462ba3d13de7a29379c2 |
| institution | Directory Open Access Journal |
| issn | 1674-2818 2049-3169 |
| language | English |
| last_indexed | 2024-12-18T01:51:29Z |
| publishDate | 2021-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | International Journal of Oral Science |
| spelling | doaj.art-b23259c9f69f462ba3d13de7a29379c22022-12-21T21:25:02ZengNature Publishing GroupInternational Journal of Oral Science1674-28182049-31692021-06-0113111210.1038/s41368-021-00126-4A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cellsSevda Pouraghaei Sevari0Sahar Ansari1Alireza Moshaverinia2Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los AngelesWeintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los AngelesWeintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los AngelesAbstract Tissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical practices. This elegant approach utilizes a natural/synthetic biomaterial with optimized physiomechanical properties to serve as a vehicle for delivery of exogenous stem cells and bioactive factors or induce local recruitment of endogenous cells for in situ tissue regeneration. Inspired by the natural microenvironment, biomaterials could act as a biomimetic three-dimensional (3D) structure to help the cells establish their natural interactions. Such a strategy should not only employ a biocompatible biomaterial to induce new tissue formation but also benefit from an easily accessible and abundant source of stem cells with potent tissue regenerative potential. The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs) with self-renewing and multilineage differentiation capabilities. In the current review article, we seek to highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches, cell transplantation and cell homing. Altogether, this paper develops a general picture of current innovative strategies to employ dental-derived MSCs combined with biomaterials and bioactive factors for regenerating the lost or defective tissues and offers information regarding the available scientific data and possible applications.https://doi.org/10.1038/s41368-021-00126-4 |
| spellingShingle | Sevda Pouraghaei Sevari Sahar Ansari Alireza Moshaverinia A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells International Journal of Oral Science |
| title | A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells |
| title_full | A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells |
| title_fullStr | A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells |
| title_full_unstemmed | A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells |
| title_short | A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells |
| title_sort | narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental derived mesenchymal stem cells |
| url | https://doi.org/10.1038/s41368-021-00126-4 |
| work_keys_str_mv | AT sevdapouraghaeisevari anarrativeoverviewofutilizingbiomaterialstorecapitulatethesalientregenerativefeaturesofdentalderivedmesenchymalstemcells AT saharansari anarrativeoverviewofutilizingbiomaterialstorecapitulatethesalientregenerativefeaturesofdentalderivedmesenchymalstemcells AT alirezamoshaverinia anarrativeoverviewofutilizingbiomaterialstorecapitulatethesalientregenerativefeaturesofdentalderivedmesenchymalstemcells AT sevdapouraghaeisevari narrativeoverviewofutilizingbiomaterialstorecapitulatethesalientregenerativefeaturesofdentalderivedmesenchymalstemcells AT saharansari narrativeoverviewofutilizingbiomaterialstorecapitulatethesalientregenerativefeaturesofdentalderivedmesenchymalstemcells AT alirezamoshaverinia narrativeoverviewofutilizingbiomaterialstorecapitulatethesalientregenerativefeaturesofdentalderivedmesenchymalstemcells |