<i>ABCG2</i> Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids
Fluoroquinolones are a widely used class of chemotherapeutics within veterinary medicine, prized for their broad-spectrum bactericidal activity. These drugs present a known risk of retinal phototoxicity in domestic cats (<i>Felis catus</i>); therefore, using lower doses and alternative a...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/12/2178 |
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| author | Alexandria E. Gochenauer Dayna L. Dreger Brian W. Davis Shawna Cook Katie E. Barber Kari J. Ekenstedt |
| author_facet | Alexandria E. Gochenauer Dayna L. Dreger Brian W. Davis Shawna Cook Katie E. Barber Kari J. Ekenstedt |
| author_sort | Alexandria E. Gochenauer |
| collection | DOAJ |
| description | Fluoroquinolones are a widely used class of chemotherapeutics within veterinary medicine, prized for their broad-spectrum bactericidal activity. These drugs present a known risk of retinal phototoxicity in domestic cats (<i>Felis catus</i>); therefore, using lower doses and alternative antibiotic classes is encouraged in this species. This adverse drug effect of fluoroquinolones, and enrofloxacin specifically, has been determined to be species-specific in domestic felids. Four feline-specific missense variants in <i>ABCG2</i> result in four amino acid changes (E159M, S279L, H283Q, and T644I) that are unique to the domestic cat compared with multiple other nonfeline mammalian species. These changes alter the ABCG2 protein involved with the cellular transmembrane transport of drugs, including fluoroquinolones, making the protein functionally defective in domestic cats. The predisposition to fluoroquinolone-mediated phototoxicity in nondomestic felids was explored in this study. At least eight nondomestic felids share the four <i>ABCG2</i> missense variants with domestic cats, and eleven other felids shared at least three of the four domestic cat variants. Taken together, these results suggest the genetic potential for nondomestic felids to also experience fluoroquinolone-induced retinal phototoxicity; therefore, cautions similar to those for domestic cats should be followed for these drugs in the entire feline taxon. |
| first_indexed | 2024-03-09T16:30:42Z |
| format | Article |
| id | doaj.art-b2331a78fede4ff58183ced081d1d13d |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T16:30:42Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-b2331a78fede4ff58183ced081d1d13d2023-11-24T15:02:15ZengMDPI AGGenes2073-44252022-11-011312217810.3390/genes13122178<i>ABCG2</i> Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic FelidsAlexandria E. Gochenauer0Dayna L. Dreger1Brian W. Davis2Shawna Cook3Katie E. Barber4Kari J. Ekenstedt5Veterinary Hospital, College of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, IN 47907, USADepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, IN 47907, USADepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University, 660 Raymond Stotzer Parkway, College Station, TX 77843, USADepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, IN 47907, USADepartment of Pharmacy Practice, School of Pharmacy, University of Mississippi, 2500 N State Street, Jackson, MS 39216, USADepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison Street, West Lafayette, IN 47907, USAFluoroquinolones are a widely used class of chemotherapeutics within veterinary medicine, prized for their broad-spectrum bactericidal activity. These drugs present a known risk of retinal phototoxicity in domestic cats (<i>Felis catus</i>); therefore, using lower doses and alternative antibiotic classes is encouraged in this species. This adverse drug effect of fluoroquinolones, and enrofloxacin specifically, has been determined to be species-specific in domestic felids. Four feline-specific missense variants in <i>ABCG2</i> result in four amino acid changes (E159M, S279L, H283Q, and T644I) that are unique to the domestic cat compared with multiple other nonfeline mammalian species. These changes alter the ABCG2 protein involved with the cellular transmembrane transport of drugs, including fluoroquinolones, making the protein functionally defective in domestic cats. The predisposition to fluoroquinolone-mediated phototoxicity in nondomestic felids was explored in this study. At least eight nondomestic felids share the four <i>ABCG2</i> missense variants with domestic cats, and eleven other felids shared at least three of the four domestic cat variants. Taken together, these results suggest the genetic potential for nondomestic felids to also experience fluoroquinolone-induced retinal phototoxicity; therefore, cautions similar to those for domestic cats should be followed for these drugs in the entire feline taxon.https://www.mdpi.com/2073-4425/13/12/2178enrofloxacinmissense variantretinaliontigercheetah |
| spellingShingle | Alexandria E. Gochenauer Dayna L. Dreger Brian W. Davis Shawna Cook Katie E. Barber Kari J. Ekenstedt <i>ABCG2</i> Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids Genes enrofloxacin missense variant retina lion tiger cheetah |
| title | <i>ABCG2</i> Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids |
| title_full | <i>ABCG2</i> Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids |
| title_fullStr | <i>ABCG2</i> Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids |
| title_full_unstemmed | <i>ABCG2</i> Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids |
| title_short | <i>ABCG2</i> Polymorphisms and Predictive Fluoroquinolone Phototoxicity in Nondomestic Felids |
| title_sort | i abcg2 i polymorphisms and predictive fluoroquinolone phototoxicity in nondomestic felids |
| topic | enrofloxacin missense variant retina lion tiger cheetah |
| url | https://www.mdpi.com/2073-4425/13/12/2178 |
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