Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder
Background and purpose: Post-traumatic stress disorder (PTSD) develops after major trauma that is accompanied by certain signs, including pervasive fear memories, anxiety, abnormality in spatial and cognition memory, and decrease in hippocampal brain-derived neurotrophic factor (BDNF). Selective ser...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2019-12-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-13822-en.html |
| _version_ | 1828055093246689280 |
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| author | Sakineh Shafia Abbas Ali Vafaei Ali RashidRy-Pour |
| author_facet | Sakineh Shafia Abbas Ali Vafaei Ali RashidRy-Pour |
| author_sort | Sakineh Shafia |
| collection | DOAJ |
| description | Background and purpose: Post-traumatic stress disorder (PTSD) develops after major trauma that is accompanied by certain signs, including pervasive fear memories, anxiety, abnormality in spatial and cognition memory, and decrease in hippocampal brain-derived neurotrophic factor (BDNF). Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PTSD. This study aimed at investigating the effects of moderate treadmill exercise and fluoxetine on spatial memory and serum BDNF levels in rat model of PTSD.
Materials and methods: In this experimental study, single prolonged stress (SPS) animal model of PTSD was used. Male and female rats were divided into SPS and control groups (n=10 per group). After that, they were subjected to moderate treadmill running (5 days per week/four weeks) and fluoxetine (10 mg/kg/day). Then, behavioral assessment and BDNF measurement were done.
Results: SPS male rats showed reduced spatial memory and hippocampal BDNF. Female rats showed more resistance to SPS than male rats. This may be due to the effects of gonadal hormones. The intervention alleviated the SPS-induced alterations in hippocampal-dependent spatial memory and BDNF serum levels in both male and female rats (P<0.05).
Conclusion: Combined exercise and fluoxetine administration are more effective in alleviating behavioral and molecular deficits in PTSD patients. |
| first_indexed | 2024-04-10T20:33:11Z |
| format | Article |
| id | doaj.art-b233490b4a53465e9250a793f1569459 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:33:11Z |
| publishDate | 2019-12-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-b233490b4a53465e9250a793f15694592023-01-25T05:07:55ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792019-12-0129179117Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress DisorderSakineh Shafia0Abbas Ali Vafaei1Ali RashidRy-Pour2 Assistant Professor, Department of Physiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Professor, Learning and Memory Research Center, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran Professor, Learning and Memory Research Center, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran Background and purpose: Post-traumatic stress disorder (PTSD) develops after major trauma that is accompanied by certain signs, including pervasive fear memories, anxiety, abnormality in spatial and cognition memory, and decrease in hippocampal brain-derived neurotrophic factor (BDNF). Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PTSD. This study aimed at investigating the effects of moderate treadmill exercise and fluoxetine on spatial memory and serum BDNF levels in rat model of PTSD. Materials and methods: In this experimental study, single prolonged stress (SPS) animal model of PTSD was used. Male and female rats were divided into SPS and control groups (n=10 per group). After that, they were subjected to moderate treadmill running (5 days per week/four weeks) and fluoxetine (10 mg/kg/day). Then, behavioral assessment and BDNF measurement were done. Results: SPS male rats showed reduced spatial memory and hippocampal BDNF. Female rats showed more resistance to SPS than male rats. This may be due to the effects of gonadal hormones. The intervention alleviated the SPS-induced alterations in hippocampal-dependent spatial memory and BDNF serum levels in both male and female rats (P<0.05). Conclusion: Combined exercise and fluoxetine administration are more effective in alleviating behavioral and molecular deficits in PTSD patients.http://jmums.mazums.ac.ir/article-1-13822-en.htmlpost-traumatic stress disordersingle prolonged stressmoderate exercisefluoxetinehippocampal dependent memorybrain-derived neurotrophic factor |
| spellingShingle | Sakineh Shafia Abbas Ali Vafaei Ali RashidRy-Pour Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder Journal of Mazandaran University of Medical Sciences post-traumatic stress disorder single prolonged stress moderate exercise fluoxetine hippocampal dependent memory brain-derived neurotrophic factor |
| title | Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder |
| title_full | Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder |
| title_fullStr | Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder |
| title_full_unstemmed | Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder |
| title_short | Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder |
| title_sort | effects of moderate treadmill exercise and fluoxetine on spatial memory and serum bdnf levels in an animal model of post traumatic stress disorder |
| topic | post-traumatic stress disorder single prolonged stress moderate exercise fluoxetine hippocampal dependent memory brain-derived neurotrophic factor |
| url | http://jmums.mazums.ac.ir/article-1-13822-en.html |
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