Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis
Objective: To evaluate the serological changes in newborns after standardized treatment of pregnant women with syphilis. Methods: Syphilis infection was retrospectively analyzed in pregnant women and newborns in the prenatal clinics from January 2012 to June 2016. Results: In 157 newborns, 40 cases...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2019-02-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/CN/abstract/abstract1671.shtml |
| _version_ | 1811250440058175488 |
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| author | Fan ZHANG Bo LI Yin-zong HUANG Hui-zhong LI |
| author_facet | Fan ZHANG Bo LI Yin-zong HUANG Hui-zhong LI |
| author_sort | Fan ZHANG |
| collection | DOAJ |
| description | Objective: To evaluate the serological changes in newborns after standardized treatment of pregnant women with syphilis. Methods: Syphilis infection was retrospectively analyzed in pregnant women and newborns in the prenatal clinics from January 2012 to June 2016. Results: In 157 newborns, 40 cases (25.5%) showed both TRUST and TPPA positive, and 106 cases (67.5%) were only TPPA positive. In newborns whose mothers were positive for both TRUST and TPPA, 40 newborns were positive for both TRUST and TPPA, and 105 newborns were TPPA positive, which both were higher than that whose mothers were only TPPA positive. In those 40 newborns with both TRUST and TPPA positive, TRUST and TPPA became negative in 39 (97.5%) and 8 (20.0%) cases, respectively, within six months. Thirty two out of these 40 newborns (80.0%) became negative for TRUST within 3 months, while 25 (62.5%) were TPPA negative within 9 months. TPPA was negative in all 40 cases within 12 months after birth. Of 106 newborns with only TPPA positive, 13 (12.3%) cases became TPPA negative within 6 months, and 75 (70.7%) cases were TPPA negative within 9 months after birth. Within 12 months after birth, all cases were TPPA negative. No neonate developed congenital syphilis during the follow-up period. Conclusion: Standardized treatment of pregnant women with syphilis can significantly reduce the risk of congenital syphilis. |
| first_indexed | 2024-04-12T16:04:41Z |
| format | Article |
| id | doaj.art-b233c6f542f8497dba873ccf60404943 |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-04-12T16:04:41Z |
| publishDate | 2019-02-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-b233c6f542f8497dba873ccf604049432022-12-22T03:26:07Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682019-02-01261283110.3969/j.issn.1674-8468.2019.01.006Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilisFan ZHANG0Bo LI1Yin-zong HUANG2Hui-zhong LI3Ma’anshan Maternal and Child Health Hospital, Ma’anshan 243011, ChinaMa’anshan Central Hospital, Ma’anshan 243099, ChinaPeople’s Hospital of Dangtu County, Ma’anshan 243100 ChinaDermatology Hospital of Southern Medical University, Guangzhou 510091, ChinaObjective: To evaluate the serological changes in newborns after standardized treatment of pregnant women with syphilis. Methods: Syphilis infection was retrospectively analyzed in pregnant women and newborns in the prenatal clinics from January 2012 to June 2016. Results: In 157 newborns, 40 cases (25.5%) showed both TRUST and TPPA positive, and 106 cases (67.5%) were only TPPA positive. In newborns whose mothers were positive for both TRUST and TPPA, 40 newborns were positive for both TRUST and TPPA, and 105 newborns were TPPA positive, which both were higher than that whose mothers were only TPPA positive. In those 40 newborns with both TRUST and TPPA positive, TRUST and TPPA became negative in 39 (97.5%) and 8 (20.0%) cases, respectively, within six months. Thirty two out of these 40 newborns (80.0%) became negative for TRUST within 3 months, while 25 (62.5%) were TPPA negative within 9 months. TPPA was negative in all 40 cases within 12 months after birth. Of 106 newborns with only TPPA positive, 13 (12.3%) cases became TPPA negative within 6 months, and 75 (70.7%) cases were TPPA negative within 9 months after birth. Within 12 months after birth, all cases were TPPA negative. No neonate developed congenital syphilis during the follow-up period. Conclusion: Standardized treatment of pregnant women with syphilis can significantly reduce the risk of congenital syphilis.http://pfxbzlx.gdvdc.com/CN/abstract/abstract1671.shtmlpregnant syphiliscongenitalcomplianceserology |
| spellingShingle | Fan ZHANG Bo LI Yin-zong HUANG Hui-zhong LI Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis Pifu-xingbing zhenliaoxue zazhi pregnant syphilis congenital compliance serology |
| title | Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis |
| title_full | Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis |
| title_fullStr | Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis |
| title_full_unstemmed | Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis |
| title_short | Serological follow-up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis |
| title_sort | serological follow up of newborns after standardized treatment of 157 pregnant women with pregnant syphilis |
| topic | pregnant syphilis congenital compliance serology |
| url | http://pfxbzlx.gdvdc.com/CN/abstract/abstract1671.shtml |
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