Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives
New coordination compounds of copper(II) with 2,5-bis(ethylthio)-1,3,4-thiadiazole (L<sup>1</sup>) and 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole (L<sup>2</sup>) with compositions Cu(L<sup>1</sup>)<sub>2</sub>Br<sub>2</sub>, Cu(L<sup&g...
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/16/13024 |
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| author | Lyudmila G. Lavrenova Taisiya S. Sukhikh Lyudmila A. Glinskaya Svetlana V. Trubina Valentina V. Zvereva Alexander N. Lavrov Lyubov S. Klyushova Alexander V. Artem’ev |
| author_facet | Lyudmila G. Lavrenova Taisiya S. Sukhikh Lyudmila A. Glinskaya Svetlana V. Trubina Valentina V. Zvereva Alexander N. Lavrov Lyubov S. Klyushova Alexander V. Artem’ev |
| author_sort | Lyudmila G. Lavrenova |
| collection | DOAJ |
| description | New coordination compounds of copper(II) with 2,5-bis(ethylthio)-1,3,4-thiadiazole (L<sup>1</sup>) and 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole (L<sup>2</sup>) with compositions Cu(L<sup>1</sup>)<sub>2</sub>Br<sub>2</sub>, Cu(L<sup>1</sup>)(C<sub>2</sub>N<sub>3</sub>)<sub>2</sub>, Cu(L<sup>2</sup>)Cl<sub>2</sub>, and Cu(L<sup>2</sup>)Br<sub>2</sub> were prepared. The complexes were identified and studied by CHN analysis, infrared (IR) spectroscopy, powder X-Ray diffraction (XRD), and static magnetic susceptibility. The crystal structures of Cu(II) complexes with L<sup>1</sup> were determined. The structures of the coordination core of complexes Cu(L<sup>2</sup>)Cl<sub>2</sub> and Cu(L<sup>2</sup>)Br<sub>2</sub> were determined by Extended X-ray absorption fine structure (EXAFS) spectroscopy. Magnetization measurements have revealed various magnetic states in the studied complexes, ranging from an almost ideal paramagnet in Cu(L<sup>1</sup>)<sub>2</sub>Br<sub>2</sub> to alternating-exchange antiferromagnetic chains in Cu(L<sup>1</sup>)(C<sub>2</sub>N<sub>3</sub>)<sub>2</sub>, where double dicyanamide bridges provide an unusually strong exchange interaction (J<sub>1</sub>/k<sub>B</sub> ≈ −23.5 K; J<sub>2</sub>/k<sub>B</sub> ≈ −20.2 K) between Cu(II) ions. The cytotoxic activity of copper(II) complexes with L<sup>2</sup> was estimated on the human cell lines of breast adenocarcinoma (<i>MCF-7</i>) and hepatocellular carcinoma (<i>HepG2</i>). |
| first_indexed | 2024-03-10T23:51:44Z |
| format | Article |
| id | doaj.art-b234a0489682411e8ddf9e09c9b6463c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:51:44Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b234a0489682411e8ddf9e09c9b6463c2023-11-19T01:34:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161302410.3390/ijms241613024Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole DerivativesLyudmila G. Lavrenova0Taisiya S. Sukhikh1Lyudmila A. Glinskaya2Svetlana V. Trubina3Valentina V. Zvereva4Alexander N. Lavrov5Lyubov S. Klyushova6Alexander V. Artem’ev7Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, RussiaNikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, RussiaNikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, RussiaNikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, RussiaNikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, RussiaNikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, RussiaInstitute of Molecular Biology and Biophysics, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk 630117, RussiaNikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, RussiaNew coordination compounds of copper(II) with 2,5-bis(ethylthio)-1,3,4-thiadiazole (L<sup>1</sup>) and 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole (L<sup>2</sup>) with compositions Cu(L<sup>1</sup>)<sub>2</sub>Br<sub>2</sub>, Cu(L<sup>1</sup>)(C<sub>2</sub>N<sub>3</sub>)<sub>2</sub>, Cu(L<sup>2</sup>)Cl<sub>2</sub>, and Cu(L<sup>2</sup>)Br<sub>2</sub> were prepared. The complexes were identified and studied by CHN analysis, infrared (IR) spectroscopy, powder X-Ray diffraction (XRD), and static magnetic susceptibility. The crystal structures of Cu(II) complexes with L<sup>1</sup> were determined. The structures of the coordination core of complexes Cu(L<sup>2</sup>)Cl<sub>2</sub> and Cu(L<sup>2</sup>)Br<sub>2</sub> were determined by Extended X-ray absorption fine structure (EXAFS) spectroscopy. Magnetization measurements have revealed various magnetic states in the studied complexes, ranging from an almost ideal paramagnet in Cu(L<sup>1</sup>)<sub>2</sub>Br<sub>2</sub> to alternating-exchange antiferromagnetic chains in Cu(L<sup>1</sup>)(C<sub>2</sub>N<sub>3</sub>)<sub>2</sub>, where double dicyanamide bridges provide an unusually strong exchange interaction (J<sub>1</sub>/k<sub>B</sub> ≈ −23.5 K; J<sub>2</sub>/k<sub>B</sub> ≈ −20.2 K) between Cu(II) ions. The cytotoxic activity of copper(II) complexes with L<sup>2</sup> was estimated on the human cell lines of breast adenocarcinoma (<i>MCF-7</i>) and hepatocellular carcinoma (<i>HepG2</i>).https://www.mdpi.com/1422-0067/24/16/13024coordination compoundscopper(II)2,5-bis(ethylthio)-1,3,4-thiadiazole2,5-bis(pyridylmethylthio)-1,3,4-thiadiazolesynthesisstructure |
| spellingShingle | Lyudmila G. Lavrenova Taisiya S. Sukhikh Lyudmila A. Glinskaya Svetlana V. Trubina Valentina V. Zvereva Alexander N. Lavrov Lyubov S. Klyushova Alexander V. Artem’ev Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives International Journal of Molecular Sciences coordination compounds copper(II) 2,5-bis(ethylthio)-1,3,4-thiadiazole 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole synthesis structure |
| title | Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives |
| title_full | Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives |
| title_fullStr | Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives |
| title_full_unstemmed | Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives |
| title_short | Synthesis, Structure, and Magnetic and Biological Properties of Copper(II) Complexes with 1,3,4-Thiadiazole Derivatives |
| title_sort | synthesis structure and magnetic and biological properties of copper ii complexes with 1 3 4 thiadiazole derivatives |
| topic | coordination compounds copper(II) 2,5-bis(ethylthio)-1,3,4-thiadiazole 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole synthesis structure |
| url | https://www.mdpi.com/1422-0067/24/16/13024 |
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