Peculiarities of the Effect of the Lipopolysaccharide of Tularemia Microbe of Different Subspecies upon Metabolic Activity of Phagocytes <i>in Vitro</i>
Experimental preparations of the lipopolysaccharide (LPS) of Francisella tularensis of four subspecies (tularensis, holarctica, mediasiatica, novicida) were obtained using Tween extraction method. Physical and chemical characteristics of the obtained preparations are presented. Examined was the effe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2011-04-01
|
| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/750 |
| Summary: | Experimental preparations of the lipopolysaccharide (LPS) of Francisella tularensis of four subspecies (tularensis, holarctica, mediasiatica, novicida) were obtained using Tween extraction method. Physical and chemical characteristics of the obtained preparations are presented. Examined was the effect of tularemia agent of different subspecies upon the phagocytic part of the experimental animals` immunity in vitro. LPS biomolecules demonstrated weak stimulating effect upon oxygen- and nitroxide-dependent bactericidal systems and lacked cytopathogenicity for phagocytes apoptosis activation. The obtained results suggest that such inactivity of tularemia agent LPS is associated with its structural peculiarities. |
|---|---|
| ISSN: | 0370-1069 2658-719X |