Evolution of Cost-Free Resistance under Fluctuating Drug Selection in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

Evolution of Cost-Free Resistance under Fluctuating Drug Selection in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

ABSTRACT Antibiotic resistance evolves rapidly in response to drug selection, but it can also persist at appreciable levels even after the removal of the antibiotic. This suggests that many resistant strains can both be resistant and have high fitness in the absence of antibiotics. To explore the co...

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Bibliographic Details
Main Authors: Anita H. Melnyk, Nicholas McCloskey, Aaron J. Hinz, Jeremy Dettman, Rees Kassen
Format: Article
Language:English
Published: American Society for Microbiology 2017-08-01
Series:mSphere
Subjects:
Pseudomonas aeruginosa
antibiotic resistance
experimental evolution
fluctuating selection
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00158-17

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