Cashew <i>(Anacardium occidentale</i> L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein
Background: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on...
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| Format: | Article |
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MDPI AG
2020-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/10/992 |
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| author | Marika Cordaro Roberta Fusco Ramona D’Amico Rosalba Siracusa Alessio Filippo Peritore Enrico Gugliandolo Tiziana Genovese Rosalia Crupi Giuseppina Mandalari Salvatore Cuzzocrea Rosanna Di Paola Daniela Impellizzeri |
| author_facet | Marika Cordaro Roberta Fusco Ramona D’Amico Rosalba Siracusa Alessio Filippo Peritore Enrico Gugliandolo Tiziana Genovese Rosalia Crupi Giuseppina Mandalari Salvatore Cuzzocrea Rosanna Di Paola Daniela Impellizzeri |
| author_sort | Marika Cordaro |
| collection | DOAJ |
| description | Background: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3), has not been fully elucidated. Methods: To investigate the effect of cashew (<i>Anacardium occidentale</i> L.) nuts on pancreatic and lung injury induced by cerulein injection, cerulein (50 μg/kg) was administered to CD1 mice for 10 h. Oral treatment with cashew nuts at a dose of 100 mg/kg was given 30 min and 2 h after the first cerulein injection. One hour after the final cerulein injection, mice were euthanized and blood, lung and pancreatic tissue samples were collected. Results: Cashew nuts were able to (1) reduce histological damage; (2) mitigate the induction of mast cell degranulation as well as the activity of myeloperoxidase and malondialdehyde; (3) decrease the activity levels of amylase and lipase as well as the levels of pro-inflammatory cytokines; and (4) enhance the activation of the Nrf2 pathway and suppress the activation of the NLRP3 pathway in response to cerulein in both pancreas and lung. Conclusions: Cashew nuts could have a beneficial effect not only on pancreatitis but also on lung injury induced by cerulein. |
| first_indexed | 2024-03-10T15:38:49Z |
| format | Article |
| id | doaj.art-b23cd89699d2447c97f6d3c016ea07e9 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T15:38:49Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-b23cd89699d2447c97f6d3c016ea07e92023-11-20T17:03:29ZengMDPI AGAntioxidants2076-39212020-10-0191099210.3390/antiox9100992Cashew <i>(Anacardium occidentale</i> L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by CeruleinMarika Cordaro0Roberta Fusco1Ramona D’Amico2Rosalba Siracusa3Alessio Filippo Peritore4Enrico Gugliandolo5Tiziana Genovese6Rosalia Crupi7Giuseppina Mandalari8Salvatore Cuzzocrea9Rosanna Di Paola10Daniela Impellizzeri11Department of Biomedical, Dental and Morphological and Functional Imaging University of Messina, 98125 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, 98168 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, ItalyBackground: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3), has not been fully elucidated. Methods: To investigate the effect of cashew (<i>Anacardium occidentale</i> L.) nuts on pancreatic and lung injury induced by cerulein injection, cerulein (50 μg/kg) was administered to CD1 mice for 10 h. Oral treatment with cashew nuts at a dose of 100 mg/kg was given 30 min and 2 h after the first cerulein injection. One hour after the final cerulein injection, mice were euthanized and blood, lung and pancreatic tissue samples were collected. Results: Cashew nuts were able to (1) reduce histological damage; (2) mitigate the induction of mast cell degranulation as well as the activity of myeloperoxidase and malondialdehyde; (3) decrease the activity levels of amylase and lipase as well as the levels of pro-inflammatory cytokines; and (4) enhance the activation of the Nrf2 pathway and suppress the activation of the NLRP3 pathway in response to cerulein in both pancreas and lung. Conclusions: Cashew nuts could have a beneficial effect not only on pancreatitis but also on lung injury induced by cerulein.https://www.mdpi.com/2076-3921/9/10/992cerulein-induced acute pancreatitiscashew nutsantioxidantinflammationpolyphenols |
| spellingShingle | Marika Cordaro Roberta Fusco Ramona D’Amico Rosalba Siracusa Alessio Filippo Peritore Enrico Gugliandolo Tiziana Genovese Rosalia Crupi Giuseppina Mandalari Salvatore Cuzzocrea Rosanna Di Paola Daniela Impellizzeri Cashew <i>(Anacardium occidentale</i> L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein Antioxidants cerulein-induced acute pancreatitis cashew nuts antioxidant inflammation polyphenols |
| title | Cashew <i>(Anacardium occidentale</i> L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein |
| title_full | Cashew <i>(Anacardium occidentale</i> L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein |
| title_fullStr | Cashew <i>(Anacardium occidentale</i> L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein |
| title_full_unstemmed | Cashew <i>(Anacardium occidentale</i> L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein |
| title_short | Cashew <i>(Anacardium occidentale</i> L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein |
| title_sort | cashew i anacardium occidentale i l nuts modulate the nrf2 and nlrp3 pathways in pancreas and lung after induction of acute pancreatitis by cerulein |
| topic | cerulein-induced acute pancreatitis cashew nuts antioxidant inflammation polyphenols |
| url | https://www.mdpi.com/2076-3921/9/10/992 |
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