Demographic and Clinicoradiological Presentation of Tuberculosis in Patients with Sickle Cell Haemoglobinopathy: A Cross-sectional Study
Introduction: Infectious disease is an important contributor to disability and death in Sickle Cell Haemoglobinopathy (SCH). India has a high burden of Tuberculosis (TB) and SCH is widespread among residents in and around Burla, Odisha. This was the first attempt to find the prevalence of SCH in act...
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JCDR Research and Publications Private Limited
2022-07-01
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| Online Access: | https://www.jcdr.net/articles/PDF/16650/53298_CE_[Nik]_F(KR)_PF1(RD_SHU_SS)_PFA(RD_KM)_PN(KM).pdf |
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| author | Ranjan Kumar Patel S Mamatha Rekha Manjhi Pravati Dutta Sudarshan Pothal Alamelu Haran |
| author_facet | Ranjan Kumar Patel S Mamatha Rekha Manjhi Pravati Dutta Sudarshan Pothal Alamelu Haran |
| author_sort | Ranjan Kumar Patel |
| collection | DOAJ |
| description | Introduction: Infectious disease is an important contributor to disability and death in Sickle Cell Haemoglobinopathy (SCH). India has a high burden of Tuberculosis (TB) and SCH is widespread among residents in and around Burla, Odisha. This was the first attempt to find the prevalence of SCH in active cases of TB in Indian adults.
Aim: To estimate the prevalence of SCH in TB and to evaluate the demographic and clinicoradiological presentation of TB in patients with SCH in a subset of Indian population.
Materials and Methods: A cross-sectional study was conducted from October 2010 to September 2012 in Department of Pulmonary Medicine of VSSMC, Burla, Odisha, India. The primary inclusion criterion was patients with TB and SCH. Demographic characteristics, clinical, radiological, microbiological and histopathology data were collected. Statistical analysis was done using Statistical Package of the Social Sciences (SPSS) 18.0. Association between categorical data was calculated using Chi-square test and Fisher’s exact test. A p-value of <0.05 was considered to be significant.
Results: Out of 1243 TB patients who were screened, 64 TB patients had SCH. The mean age of the patients were 30.41±13.48 years with female predominance 33 (51.56%). The prevalence of SCH in TB was 51.49/1000, Sickle Cell Anaemia (SCA) was 13.68/1000 and Sickle Cell Trait (SCT) was 37.81/1000. Total 47 (73.43%) patients had SCT and 17 (26.56%) patients had SCA. Majority of patients with SCA 15 (88.23%) and SCT 35 (74.46%) belonged to the age of ≤40 years. Total 38 (59.37%) patients had Pulmonary TB (PTB) and 26 (40.62%) had Extrapulmonary TB (EPTB). EPTB 11 (64.70%) was common in patients with SCA than PTB 6 (35.29%) and vice-versa in SCT 15 (31.91% vs 32 (68.08%) (p=0.018). Among PTB patients, cough was the most common symptom seen in 7 (10.93%) patients of SCA and in 26 (40.62%) patients of SCT. The mean (±SD) haemoglobin in patients with SCA was 7.270 (±2.007) gm% and SCT was 9.021 (±1.578) gm% (p-value=0.002). The most common chest radiographic finding was nodules in patients with SCA 9 (52.94%), reticular opacities and pleural effusion 11 (23.40%) each in SCT.
Conclusion: In the present study, 5.14% of TB patients had SCH. Pulmonary TB (PTB) was more common than EPTB in patients with SCH. |
| first_indexed | 2024-04-10T09:51:18Z |
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| language | English |
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| spelling | doaj.art-b23dabbcbade4408b1d19f10f5d9a8692023-02-17T04:40:04ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-07-01167OC22OC2510.7860/JCDR/2022/53298.16650Demographic and Clinicoradiological Presentation of Tuberculosis in Patients with Sickle Cell Haemoglobinopathy: A Cross-sectional StudyRanjan Kumar Patel0S Mamatha1Rekha Manjhi2Pravati Dutta3Sudarshan Pothal4Alamelu Haran5Consultant, Department of Respiratory Medicine, Shri Medishine Hospital, Raipur, Chattisgarh, India.Associate Professor, Department of Respiratory Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka.Associate Professor, Department of Pulmonary Medicine, Veer Surendra Sai University, Burla, Odisha, India.Professor, Department of Pulmonary Medicine, Veer Surendra Sai University, Burla, Odisha, India.Associate Professor, Department of Pulmonary Medicine, Veer Surendra Sai University, Burla, Odisha, India.Professor and Head, Department of Respiratory Medicine, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka , India.Introduction: Infectious disease is an important contributor to disability and death in Sickle Cell Haemoglobinopathy (SCH). India has a high burden of Tuberculosis (TB) and SCH is widespread among residents in and around Burla, Odisha. This was the first attempt to find the prevalence of SCH in active cases of TB in Indian adults. Aim: To estimate the prevalence of SCH in TB and to evaluate the demographic and clinicoradiological presentation of TB in patients with SCH in a subset of Indian population. Materials and Methods: A cross-sectional study was conducted from October 2010 to September 2012 in Department of Pulmonary Medicine of VSSMC, Burla, Odisha, India. The primary inclusion criterion was patients with TB and SCH. Demographic characteristics, clinical, radiological, microbiological and histopathology data were collected. Statistical analysis was done using Statistical Package of the Social Sciences (SPSS) 18.0. Association between categorical data was calculated using Chi-square test and Fisher’s exact test. A p-value of <0.05 was considered to be significant. Results: Out of 1243 TB patients who were screened, 64 TB patients had SCH. The mean age of the patients were 30.41±13.48 years with female predominance 33 (51.56%). The prevalence of SCH in TB was 51.49/1000, Sickle Cell Anaemia (SCA) was 13.68/1000 and Sickle Cell Trait (SCT) was 37.81/1000. Total 47 (73.43%) patients had SCT and 17 (26.56%) patients had SCA. Majority of patients with SCA 15 (88.23%) and SCT 35 (74.46%) belonged to the age of ≤40 years. Total 38 (59.37%) patients had Pulmonary TB (PTB) and 26 (40.62%) had Extrapulmonary TB (EPTB). EPTB 11 (64.70%) was common in patients with SCA than PTB 6 (35.29%) and vice-versa in SCT 15 (31.91% vs 32 (68.08%) (p=0.018). Among PTB patients, cough was the most common symptom seen in 7 (10.93%) patients of SCA and in 26 (40.62%) patients of SCT. The mean (±SD) haemoglobin in patients with SCA was 7.270 (±2.007) gm% and SCT was 9.021 (±1.578) gm% (p-value=0.002). The most common chest radiographic finding was nodules in patients with SCA 9 (52.94%), reticular opacities and pleural effusion 11 (23.40%) each in SCT. Conclusion: In the present study, 5.14% of TB patients had SCH. Pulmonary TB (PTB) was more common than EPTB in patients with SCH.https://www.jcdr.net/articles/PDF/16650/53298_CE_[Nik]_F(KR)_PF1(RD_SHU_SS)_PFA(RD_KM)_PN(KM).pdfanaemiaextrapulmonarymontoux testpulmonary tuberculosissickle cell haemoglobinopathy |
| spellingShingle | Ranjan Kumar Patel S Mamatha Rekha Manjhi Pravati Dutta Sudarshan Pothal Alamelu Haran Demographic and Clinicoradiological Presentation of Tuberculosis in Patients with Sickle Cell Haemoglobinopathy: A Cross-sectional Study Journal of Clinical and Diagnostic Research anaemia extrapulmonary montoux test pulmonary tuberculosis sickle cell haemoglobinopathy |
| title | Demographic and Clinicoradiological Presentation of Tuberculosis in Patients with Sickle Cell Haemoglobinopathy: A Cross-sectional Study |
| title_full | Demographic and Clinicoradiological Presentation of Tuberculosis in Patients with Sickle Cell Haemoglobinopathy: A Cross-sectional Study |
| title_fullStr | Demographic and Clinicoradiological Presentation of Tuberculosis in Patients with Sickle Cell Haemoglobinopathy: A Cross-sectional Study |
| title_full_unstemmed | Demographic and Clinicoradiological Presentation of Tuberculosis in Patients with Sickle Cell Haemoglobinopathy: A Cross-sectional Study |
| title_short | Demographic and Clinicoradiological Presentation of Tuberculosis in Patients with Sickle Cell Haemoglobinopathy: A Cross-sectional Study |
| title_sort | demographic and clinicoradiological presentation of tuberculosis in patients with sickle cell haemoglobinopathy a cross sectional study |
| topic | anaemia extrapulmonary montoux test pulmonary tuberculosis sickle cell haemoglobinopathy |
| url | https://www.jcdr.net/articles/PDF/16650/53298_CE_[Nik]_F(KR)_PF1(RD_SHU_SS)_PFA(RD_KM)_PN(KM).pdf |
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