The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis.
ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3796483?pdf=render |
| _version_ | 1823928773043552256 |
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| author | Agnese Serafini Davide Pisu Giorgio Palù G Marcela Rodriguez Riccardo Manganelli |
| author_facet | Agnese Serafini Davide Pisu Giorgio Palù G Marcela Rodriguez Riccardo Manganelli |
| author_sort | Agnese Serafini |
| collection | DOAJ |
| description | ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and its involvement in the adaptation to low zinc environment in M. tuberculosis. Moreover, we unveiled functional differences between the ESX-3 roles in M. tuberculosis and M. smegmatis showing that in the latter ESX-3 is only involved in the adaptation to iron and not to zinc restriction. Finally, we also showed that in M. tuberculosis this secretion system is essential for iron and zinc homeostasis not only in conditions in which the concentrations of these metals are limiting but also in metal sufficient conditions. |
| first_indexed | 2024-12-16T20:59:29Z |
| format | Article |
| id | doaj.art-b23dea5938134925a0c45ce9b9e34318 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T20:59:29Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b23dea5938134925a0c45ce9b9e343182022-12-21T22:16:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7835110.1371/journal.pone.0078351The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis.Agnese SerafiniDavide PisuGiorgio PalùG Marcela RodriguezRiccardo ManganelliESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study we confirmed the role of ESX-3 in iron uptake and its involvement in the adaptation to low zinc environment in M. tuberculosis. Moreover, we unveiled functional differences between the ESX-3 roles in M. tuberculosis and M. smegmatis showing that in the latter ESX-3 is only involved in the adaptation to iron and not to zinc restriction. Finally, we also showed that in M. tuberculosis this secretion system is essential for iron and zinc homeostasis not only in conditions in which the concentrations of these metals are limiting but also in metal sufficient conditions.http://europepmc.org/articles/PMC3796483?pdf=render |
| spellingShingle | Agnese Serafini Davide Pisu Giorgio Palù G Marcela Rodriguez Riccardo Manganelli The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis. PLoS ONE |
| title | The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis. |
| title_full | The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis. |
| title_fullStr | The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis. |
| title_full_unstemmed | The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis. |
| title_short | The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis. |
| title_sort | esx 3 secretion system is necessary for iron and zinc homeostasis in mycobacterium tuberculosis |
| url | http://europepmc.org/articles/PMC3796483?pdf=render |
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