The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs

The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs

Up to date, preclinical screening for new antiepileptic substances is performed by a combination of different in vivo models of acute seizures, for which large numbers of animals are necessary. So far, little attention has been paid to in vitro models, which are also able to detect antiepileptic eff...

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Bibliographic Details
Main Authors: Hanno Heuzeroth, Matthias Wawra, Pawel Fidzinski, Ramazan Dag, Martin Holtkamp
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
4-aminopyridine
levetiracetam
lacosamide
zonisamide
in vitro
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00677/full

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