Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action
Ulises Coffeen, Francisco Pellicer Research in Neurosciences, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, México Abstract: Salvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-03-01
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| Series: | Journal of Pain Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/salvia-divinorum-from-recreational-hallucinogenic-use-to-analgesic-and-peer-reviewed-article-JPR |
| _version_ | 1818944792605753344 |
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| author | Coffeen U Pellicer F |
| author_facet | Coffeen U Pellicer F |
| author_sort | Coffeen U |
| collection | DOAJ |
| description | Ulises Coffeen, Francisco Pellicer Research in Neurosciences, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, México Abstract: Salvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, S. divinorum extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Its main active component is a diterpene named salvinorin A (SA), a potent naturally occurring hallucinogen with a great affinity to the κ opioid receptors and with allosteric modulation of cannabinoid type 1 receptors. Recent biochemical research has revealed the mechanism of action of the anti-inflammatory and analgesic effect of SA at the cellular and molecular level. Nevertheless, because of their short-lasting and hallucinogenic effect, the research has focused on discovering a new analogue of SA that is able to induce analgesia and reduce inflammation with a long-lasting effect but without the hallucinatory component. In this review, we explore the role of S. divinorum, SA and its analogues. We focus mainly on their analgesic and anti-inflammatory roles but also mention their psychoactive properties. Keywords: Salvia divinorum, salvinorin A, pain, inflammation, psychoactivity |
| first_indexed | 2024-12-20T07:48:51Z |
| format | Article |
| id | doaj.art-b241accb79a642d0a26de5ca30c69c8d |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-20T07:48:51Z |
| publishDate | 2019-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-b241accb79a642d0a26de5ca30c69c8d2022-12-21T19:47:54ZengDove Medical PressJournal of Pain Research1178-70902019-03-01Volume 121069107644721Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory actionCoffeen UPellicer FUlises Coffeen, Francisco Pellicer Research in Neurosciences, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, México Abstract: Salvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, S. divinorum extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Its main active component is a diterpene named salvinorin A (SA), a potent naturally occurring hallucinogen with a great affinity to the κ opioid receptors and with allosteric modulation of cannabinoid type 1 receptors. Recent biochemical research has revealed the mechanism of action of the anti-inflammatory and analgesic effect of SA at the cellular and molecular level. Nevertheless, because of their short-lasting and hallucinogenic effect, the research has focused on discovering a new analogue of SA that is able to induce analgesia and reduce inflammation with a long-lasting effect but without the hallucinatory component. In this review, we explore the role of S. divinorum, SA and its analogues. We focus mainly on their analgesic and anti-inflammatory roles but also mention their psychoactive properties. Keywords: Salvia divinorum, salvinorin A, pain, inflammation, psychoactivity https://www.dovepress.com/salvia-divinorum-from-recreational-hallucinogenic-use-to-analgesic-and-peer-reviewed-article-JPRSalvia divinorumSalvinorin APainInflammationPsychoactivity |
| spellingShingle | Coffeen U Pellicer F Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action Journal of Pain Research Salvia divinorum Salvinorin A Pain Inflammation Psychoactivity |
| title | Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action |
| title_full | Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action |
| title_fullStr | Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action |
| title_full_unstemmed | Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action |
| title_short | Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action |
| title_sort | salvia divinorum from recreational hallucinogenic use to analgesic and anti inflammatory action |
| topic | Salvia divinorum Salvinorin A Pain Inflammation Psychoactivity |
| url | https://www.dovepress.com/salvia-divinorum-from-recreational-hallucinogenic-use-to-analgesic-and-peer-reviewed-article-JPR |
| work_keys_str_mv | AT coffeenu salviadivinorumfromrecreationalhallucinogenicusetoanalgesicandantiinflammatoryaction AT pellicerf salviadivinorumfromrecreationalhallucinogenicusetoanalgesicandantiinflammatoryaction |